Calcifications

and the Therapeutically

HERMAN

Downloaded from www.ajronline.org by 190.122.132.98 on 11/05/15 from IP address 190.122.132.98. Copyright ARRS. For personal use only; all rights reserved

Mammograms

of

81

I. LIBSHITZ,’

patients

who

ELEANOR

received

D. MONTAGUE,2AND

radiation

therapy to the breast were analyzed for patterns of preand postirradiation calcifications. Malignant calcifications may remain stable, diminish, or completely disappear following irradiation. The persistence of calcifications need not indicate residual cancer. Calcifications can develop following irradiation which are similar to either intraductal or secretory calcifications. Unusual calcifications may develop at the site of an irradiated cancer. It is important to recognize that benign calcifications can develop so that they will not be confused with recurrent malignancy.

Clinical

patients

should

who

be an effective

have

received

carcinoma of the breast. able on the appearance therapy.

Little

fications

in the

breast,

the

possible

regarding cations malignant

after

therapeutic

Records Institute

about nor

the

however, following

fate

is much

of malignant

development

irradiation. calcifications

This and

following

of

benign

radiation

Materials

and

Methods

received

at M. D. Anderson radiation

Hospital

therapy

to the

up

who

data

were

included.

therapy

Of

following

underwent

therapy

biopsy.

The

the

81

excision

following

average

age

met

biopsy

either

for

the

and Tumor

breast

mammograms had complete

ional

for

both clinical

these

carci-

before follow-

criteria,

35

(tumorectomy)

needle

biopsy

groups

was

two

and

or incis51

and

55

in

the

respectively.

Malignant

calcifications

were

seen

in

12

patients

needle/incision group. The appearance of the calcifications following irradiation was noted. Benign calcifications developed in four patients who underwent tumorectomy and in seven of the needle/incision biopsy group. Three patients with malignant

for

calci-

calcifications

available

report describes the development

D. PAULUS’

noma were reviewed. Those with and after radiation therapy and who

46

are availradiation

information

DAVID

of all patients who

received

of following irradiation

Few reports, of the breast

is known

calcifications

method

Breast

Material

years. Mammography

Irradiated

elsewhere

subsequently in the

treated

developed

benign

calcifications

breast.

calcifiMethod

changes in of benign

The types.

therapy.

of Treatment radiation

therapy

regimens

can

be

divided

into

three

1’ S

“a

I

-

S

.s

k

-

,

.1. 4-

.

‘ ..

.,

F

.B. i

a

4

$

-a ‘ . ,

a .‘.

4



.

,

Fig.

(7,100

1.-A.

2

Am

Enlarged

rad) showing

Received 77030.

-4

.-

A

craniocaudad

disappearance

December

13, 1976;

Department

of Diagnostic

Address Department

reprint requests of Radiotherapy,

J Roentgenol

128:1021-1025,

view

of mass

accepted

Radiology.

of

breast

and decrease

after

revision

University

to H. I. Libshitz. University of Texas June

showing

1977

-;.i

cancer in malignant

March

,,f,:

with associated calcifications.

malignant

S

B, Same

calcifications.

breast

19 months

after

therapy

7. 1977.

of Texas System System

-a, -S

c.

Cancer

Cancer

Center.

Center,

M.

1021

M. D Anderson

D. Anderson

Hospital

Hospital and

and

Tumor

Tumor

Institute.

Institute.

Houston,

Houston.

Texas

Texas

77030

Downloaded from www.ajronline.org by 190.122.132.98 on 11/05/15 from IP address 190.122.132.98. Copyright ARRS. For personal use only; all rights reserved

1022

LIBSHITZ

El

AL.

.J,’.

.-

01.4

,m-

.

a,

I.,

L4,

‘1

,

ir

.B 2

.vith

A, Enlarged

-

‘malignant showing

-rad)

craniocudad

patients

were

malignant

of left

bret

breast,.

showing

17 months

calcificati#{244}’ns

‘treated:o!

nodal

me’nt

ofradial’and

consisted

: received and

after

andsizeof

cinically

breast

60Co

(8.400

Two

44

rounded

months

after,

alcifications

Note ‘

.

-

primary

ioperabI&’The

protracted

was

were

LSflourouracil

treat

iradiation

with

a

.!

therapy ,consisted

.

-

through i

;,

neutrons!to,the

-‘p

breast.

inflammatory

carci-

.5 :.

observation of. ytherna. peau Four of these patients had either in

combination

with

adriamycin

cr

1

a-

..

pp,aentrecIved,.4OO,

rad

.

,

. .

. ,-

inseven ‘

iai,tumoLclose

had

cIunucallyopefable and

tumorwere

excised ..

-f

grave

and followed

Irr#{227}diationwas ..

radA’in.5

bfollowed by reduced fields !fan#{225}dditionIL1.OOO_1.2SO

I

_.

plus

5 cm

without

plus

.:

fields

patients

5.000

tumor.doe

“L

reduced

less than

coerving’thebreast.

delivering.

..

oxygen?conditionS

classical

t#{243}tal

Calcifications and the therapeutically irradiated breast.

Calcifications and the Therapeutically HERMAN Downloaded from www.ajronline.org by 190.122.132.98 on 11/05/15 from IP address 190.122.132.98. Copyr...
927KB Sizes 0 Downloads 0 Views