ORIGINAL ARTICLE Journal of Cachexia, Sarcopenia and Muscle 2017; 8: 457–465 Published online 1 March 2017 in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/jcsm.12184
C-reactive protein, symptoms and activity of daily living in patients with advanced cancer receiving palliative care Koji Amano1*, Isseki Maeda2, Tatsuya Morita3, Mika Baba4, Tomofumi Miura5, Takashi Hama6, Ichiro Mori7, Nobuhisa Nakajima8, Tomohiro Nishi9, Hiroki Sakurai10, Satofumi Shimoyama11, Takuya Shinjo12, Hiroto Shirayama13, Takeshi Yamada14, Shigeki Ono15, Taketoshi Ozawa16, Ryo Yamamoto17, Naoki Yamamoto18, Hideki Shishido19 & Hiroya Kinoshita20 1 Department of Palliative Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka City, 534-0021, Japan; 2Department of Palliative Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; 3Palliative and Supportive Care Division, Seirei Mikatahara General Hospital, 3453 Mikatahara-cho, Kita-ku, Hamamatsu, Shizuoka, 433-8558, Japan; 4Department of Palliative Care, Saito Yukoukai Hospital, 7-2-18 Saito Asagi, Ibaragi, Osaka, 567-0085, Japan; 5Department of Palliative Medicine, National Cancer Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chibay, 277-8577, Japan; 6Palliative Care Team, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka, 537-8511, Japan; 7Gratia Hospital Hospice, 6-14-1 Aomadaninishi, Mino, Osaka, 562-8567, Japan; 8Department of Palliative Medicine, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aobaku, Sendai, Miyagi, 980-8574, Japan; 9Kawasaki Comprehensive Care Center, Kawasaki Municipal Ida Hospital, 2-27-1 Ida Nakahara-ku, Kawasaki, Kanagawa, 211-0035, Japan; 10 Department of Palliative Care, St. Luke’s International Hospital, Tokyo, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan; 11Department of Palliative Care, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan; 12Shinjo Clinic, Kobe, 1-5-1-307 Kitagoyou, Kita-ku, Kobe, Hyogo, 651-1131, Japan; 13Osaka Kita Homecare Clinic, Shin-Osaka 3rd Doi-biru 3F, 1-8-24 Nisimiyahara Yodogawa-ku, Osaka, 532-0004, Japan; 14Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan; 15Division of Palliative Medicine, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Suntou-gun, Shizuoka, 411-8777, Japan; 16Megumi Zaitaku Clinic, 2-4-3 Hashido, Seya-ku, Yokohama, Kanagawa, 246-0037, Japan; 17 Department of Palliative Medicine, Saku Central Hospital Advanced Care Center, 3400-28 Nakagomi, Saku, Nagano, 385-0051, Japan; 18Department of Primary Care Service, Shinsei Hospital, 851 Obusechou, Kamitakai-gun, Nagano, 381-0295, Japan; 19Shishido Internal Medicine Clinic, 1-18-7 Ojidai, Sakura, Chiba, 285-0837, Japan; 20 Department of Palliative Medicine, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan
Abstract Background The association between C-reactive protein (CRP) level, symptoms, and activities of daily living (ADL) in advanced cancer patients is unclear. Methods Secondary data analysis of a multicenter prospective cohort study consisted of 2426 advanced cancer patients referred to palliative care settings was conducted to examine the cross-sectional relationships between CRP level, symptoms, and ADL disabilities. Laboratory data, symptoms, ADL, and manual muscle testing (MMT) results were obtained at baseline. Participants were divided into four groups: low (CRP < 1 mg/dl), moderate (1 = < CRP
C-reactive protein, symptoms and activity of daily living in patients with advanced cancer receiving palliative care Koji Amano1*, Isseki Maeda2, Tatsuya Morita3, Mika Baba4, Tomofumi Miura5, Takashi Hama6, Ichiro Mori7, Nobuhisa Nakajima8, Tomohiro Nishi9, Hiroki Sakurai10, Satofumi Shimoyama11, Takuya Shinjo12, Hiroto Shirayama13, Takeshi Yamada14, Shigeki Ono15, Taketoshi Ozawa16, Ryo Yamamoto17, Naoki Yamamoto18, Hideki Shishido19 & Hiroya Kinoshita20 1 Department of Palliative Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka City, 534-0021, Japan; 2Department of Palliative Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; 3Palliative and Supportive Care Division, Seirei Mikatahara General Hospital, 3453 Mikatahara-cho, Kita-ku, Hamamatsu, Shizuoka, 433-8558, Japan; 4Department of Palliative Care, Saito Yukoukai Hospital, 7-2-18 Saito Asagi, Ibaragi, Osaka, 567-0085, Japan; 5Department of Palliative Medicine, National Cancer Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chibay, 277-8577, Japan; 6Palliative Care Team, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka, 537-8511, Japan; 7Gratia Hospital Hospice, 6-14-1 Aomadaninishi, Mino, Osaka, 562-8567, Japan; 8Department of Palliative Medicine, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aobaku, Sendai, Miyagi, 980-8574, Japan; 9Kawasaki Comprehensive Care Center, Kawasaki Municipal Ida Hospital, 2-27-1 Ida Nakahara-ku, Kawasaki, Kanagawa, 211-0035, Japan; 10 Department of Palliative Care, St. Luke’s International Hospital, Tokyo, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan; 11Department of Palliative Care, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan; 12Shinjo Clinic, Kobe, 1-5-1-307 Kitagoyou, Kita-ku, Kobe, Hyogo, 651-1131, Japan; 13Osaka Kita Homecare Clinic, Shin-Osaka 3rd Doi-biru 3F, 1-8-24 Nisimiyahara Yodogawa-ku, Osaka, 532-0004, Japan; 14Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan; 15Division of Palliative Medicine, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Suntou-gun, Shizuoka, 411-8777, Japan; 16Megumi Zaitaku Clinic, 2-4-3 Hashido, Seya-ku, Yokohama, Kanagawa, 246-0037, Japan; 17 Department of Palliative Medicine, Saku Central Hospital Advanced Care Center, 3400-28 Nakagomi, Saku, Nagano, 385-0051, Japan; 18Department of Primary Care Service, Shinsei Hospital, 851 Obusechou, Kamitakai-gun, Nagano, 381-0295, Japan; 19Shishido Internal Medicine Clinic, 1-18-7 Ojidai, Sakura, Chiba, 285-0837, Japan; 20 Department of Palliative Medicine, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan
Abstract Background The association between C-reactive protein (CRP) level, symptoms, and activities of daily living (ADL) in advanced cancer patients is unclear. Methods Secondary data analysis of a multicenter prospective cohort study consisted of 2426 advanced cancer patients referred to palliative care settings was conducted to examine the cross-sectional relationships between CRP level, symptoms, and ADL disabilities. Laboratory data, symptoms, ADL, and manual muscle testing (MMT) results were obtained at baseline. Participants were divided into four groups: low (CRP < 1 mg/dl), moderate (1 = < CRP
