Original Article Buparvaquone loaded solid lipid nanoparticles for targeted delivery in theleriosis Maheshkumar P. Soni, Nilakash Shelkar1, Rajiv V. Gaikwad2, Geeta R. Vanage1, Abdul Samad2, Padma V. Devarajan

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, 1 National Centre for Preclinical Reproductive and Genetic Toxicology, National Institute for Research in Reproductive Health, 2Department of Veterinary Nuclear Medicine, Maharashtra Animal and Fishery Sciences University, Bombay Veterinary College, Mumbai, Maharashtra, India Address for correspondence: Dr. Padma V. Devarajan, E‑mail: pvdevarajan@gmail. com

Received : 21-11-13 Review completed : 21-11-13 Accepted : 21-11-13

ABSTRACT Background: Buparvaquone (BPQ), a hydroxynaphthoquinone derivative, has been investigated for the treatment of many infections and is recommended as the gold standard for the treatment of theileriosis. Theileriosis, an intramacrophage infection is localized mainly in reticuloendotheileial system (RES) organs. The present study investigates development of solid lipid nanoparticles (SLN) of BPQ for targeted delivery to the RES. Materials and Methods: BPQ SLN was prepared using melt method by adding a molten mixture into aqueous Lutrol F68 solution (80°C). Larger batches were prepared up to 6 g of BPQ with GMS: BPQ, 2:1. SLN of designed size were obtained using ultraturrax and high pressure homogenizer. A freeze and thaw study was used to optimize type and concentration of cryoprotectant with Sf: Mean particle size, Si: Initial particle size

Buparvaquone loaded solid lipid nanoparticles for targeted delivery in theleriosis.

Buparvaquone (BPQ), a hydroxynaphthoquinone derivative, has been investigated for the treatment of many infections and is recommended as the gold stan...
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