Ann Hematol DOI 10.1007/s00277-013-1943-6

LETTER TO THE EDITOR

Breakthrough Fusarium solani infection in a patient with acute myeloid leukemia receiving posaconazole prophylaxis Cheng-Han Wu & Po-Liang Lu & Hui-Hua Hsiao & Ta-Chih Liu & Sheng-Fung Lin & Chao-Sung Chang & Jui-Feng Hsu & Yi-Chang Liu

Received: 4 October 2013 / Accepted: 15 October 2013 # Springer-Verlag Berlin Heidelberg 2013

Dear Editor, A 23-year-old woman presented with fever, exertional dyspnea, and bruised limbs was diagnosed as having acute myeloid leukemia (AML; French–American–British classification type M0) with normal metaphase cytogenetics and negative NPM1, FLT3-ITD, and CEBPA gene mutations. Laboratory evaluations revealed a leukocyte count of 65,800/μL (blasts 83.5 %), hemoglobin of 3.8 g/dL, and platelets of 9,000/μL. She received induction chemotherapy with idarubicin and cytarabine (I3A7) along with cefepime. The fever subsided without identified organisms. Posaconazole (200 mg three times daily) was started as antifungal prophylaxis on day 1 of chemotherapy. The fever recurred on day 9, and the antibiotics were shifted to imipenam/cilastatin and vancomycin. However, the fever persisted, and multiple tender erythematous papules

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Breakthrough Fusarium solani infection in a patient with acute myeloid leukemia receiving posaconazole prophylaxis.

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