Accepted Manuscript Title: Brain magnetic resonance imaging findings in cryptogenic stroke patients under 60 years with patent foramen ovale Author: Claire Boutet Laure Rouffiange-Leclair Fabrice-Guy Barral Pierre Garnier J´erˆome Varvat Magali Epinat Jean-Christophe Antoine Sara Quenet Daphn´e Delsart Patrick Mismetti PII: DOI: Reference:
S0720-048X(14)00058-8 http://dx.doi.org/doi:10.1016/j.ejrad.2014.01.022 EURR 6668
To appear in:
European Journal of Radiology
Received date: Revised date: Accepted date:
8-7-2013 19-1-2014 27-1-2014
Please cite this article as: Boutet C, Rouffiange-Leclair L, Barral F-G, Garnier P, Varvat J, Epinat M, Antoine J-C, Quenet S, Delsart D, Mismetti P, Brain magnetic resonance imaging findings in cryptogenic stroke patients under 60 years with patent foramen ovale., European Journal of Radiology (2014), http://dx.doi.org/10.1016/j.ejrad.2014.01.022 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
First Title Page
Title: Brain magnetic resonance imaging findings in cryptogenic stroke patients under 60 years with
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patent foramen ovale.
Authors:
us
Claire Boutet, MD, PhD:
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Department of Radiology, University Hospital of Saint-Etienne, France
Phone.: +33 477 828 355
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Email: [email protected]
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Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France
Laure Rouffiange-Leclair, MD:
Ac ce p
Department of Radiology, University Hospital of Saint-Etienne, France Phone.: +33 477 828 355
Email: [email protected]
Fabrice-Guy Barral MD, PhD:
Department of Radiology, University Hospital of Saint-Etienne, Hôpital Nord, 42055 SaintEtienne Cedex 2, France Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France
1 Page 1 of 25
Phone.: +33 477 828 355 Email: [email protected]
Department of Neurology, University Hospital of Saint-Etienne, France
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Pierre Garnier, MD:
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Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France
us
Phone.: +33 477 828 355
an
Email : [email protected]
Jérôme Varvat, MD:
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Department of Neurology, University Hospital of Saint-Etienne, France
Ac ce p
Email: [email protected]
te
Phone.: +33 477 828 355
d
Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France
Magali Epinat, MD:
Department of Neurology, University Hospital of Saint-Etienne, France Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France Phone.: +33 477 828 355
Email: [email protected]
Jean-Christophe Antoine MD, PhD: Department of Neurology, University Hospital of Saint-Etienne, France
2 Page 2 of 25
Lyon Neuroscience Research Center, INSERM U1028 - CNRS UMR5292 EA 4338, Jean Monnet University, Saint-Etienne, France Phone.: +33 477 828 355
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Email: [email protected]
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Sara Quenet, MD:
us
Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France Phone.: +33 477 828 355
M
Daphné Delsart, MD:
an
Email: [email protected]
Department of Therapeutic Medicine, CHU Saint-Etienne, Hôpital Nord, Saint-Etienne,
d
France
te
Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France
Ac ce p
Inserm, CIE3, F- 42055 Saint-Etienne, France Phone.: +33 477 828 355
Email: [email protected]
Patrick Mismetti, MD, PhD:
Department of Therapeutic Medicine, CHU Saint-Etienne, Hôpital Nord, Saint-Etienne, France Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France Inserm, CIE3, F- 42055 Saint-Etienne, France Phone.: +33 477 828 355 3 Page 3 of 25
Email: [email protected]
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Corresponding author: Claire Boutet
cr
University Hospital of Saint Etienne, Hôpital Nord,
us
42055 Saint Etienne Cedex 2 Phone.: +33 477 828 355
an
Fax: +33 477 120 547
Ac ce p
te
d
M
Email: [email protected]
4 Page 4 of 25
ABSTRACT Purpose: To compare magnetic resonance imaging (MRI) brain feature in cryptogenic stroke patients with patent foramen ovale (PFO), cryptogenic stroke patients without PFO and
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patients with cardioembolic stroke. Materials and methods: The ethics committee required neither institutional review board
cr
approval nor informed patient consent for retrospective analyses of the patients' medical
us
records and imaging data. The patients' medical files were retrospectively reviewed in accordance with human subject research protocols. Ninety-two patients under 60 years of age
an
were included; 15 with cardioembolic stroke, 32 with cryptogenic stroke with PFO and 45 with cryptogenic stroke without PFO. Diffusion-weighted imaging of brain MRI was
M
performed by a radiologist blinded to clinical data. Univariate, Fischer’s exact test for qualitative data and non-parametric Wilcoxon test for quantitative data were used.
d
Results: There was no statistically significant difference found between MRI features of
te
patients with PFO and those with cardioembolic stroke (p
S0720-048X(14)00058-8 http://dx.doi.org/doi:10.1016/j.ejrad.2014.01.022 EURR 6668
To appear in:
European Journal of Radiology
Received date: Revised date: Accepted date:
8-7-2013 19-1-2014 27-1-2014
Please cite this article as: Boutet C, Rouffiange-Leclair L, Barral F-G, Garnier P, Varvat J, Epinat M, Antoine J-C, Quenet S, Delsart D, Mismetti P, Brain magnetic resonance imaging findings in cryptogenic stroke patients under 60 years with patent foramen ovale., European Journal of Radiology (2014), http://dx.doi.org/10.1016/j.ejrad.2014.01.022 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
First Title Page
Title: Brain magnetic resonance imaging findings in cryptogenic stroke patients under 60 years with
cr
ip t
patent foramen ovale.
Authors:
us
Claire Boutet, MD, PhD:
an
Department of Radiology, University Hospital of Saint-Etienne, France
Phone.: +33 477 828 355
te
d
Email: [email protected]
M
Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France
Laure Rouffiange-Leclair, MD:
Ac ce p
Department of Radiology, University Hospital of Saint-Etienne, France Phone.: +33 477 828 355
Email: [email protected]
Fabrice-Guy Barral MD, PhD:
Department of Radiology, University Hospital of Saint-Etienne, Hôpital Nord, 42055 SaintEtienne Cedex 2, France Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France
1 Page 1 of 25
Phone.: +33 477 828 355 Email: [email protected]
Department of Neurology, University Hospital of Saint-Etienne, France
ip t
Pierre Garnier, MD:
cr
Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France
us
Phone.: +33 477 828 355
an
Email : [email protected]
Jérôme Varvat, MD:
M
Department of Neurology, University Hospital of Saint-Etienne, France
Ac ce p
Email: [email protected]
te
Phone.: +33 477 828 355
d
Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France
Magali Epinat, MD:
Department of Neurology, University Hospital of Saint-Etienne, France Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France Phone.: +33 477 828 355
Email: [email protected]
Jean-Christophe Antoine MD, PhD: Department of Neurology, University Hospital of Saint-Etienne, France
2 Page 2 of 25
Lyon Neuroscience Research Center, INSERM U1028 - CNRS UMR5292 EA 4338, Jean Monnet University, Saint-Etienne, France Phone.: +33 477 828 355
ip t
Email: [email protected]
cr
Sara Quenet, MD:
us
Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France Phone.: +33 477 828 355
M
Daphné Delsart, MD:
an
Email: [email protected]
Department of Therapeutic Medicine, CHU Saint-Etienne, Hôpital Nord, Saint-Etienne,
d
France
te
Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France
Ac ce p
Inserm, CIE3, F- 42055 Saint-Etienne, France Phone.: +33 477 828 355
Email: [email protected]
Patrick Mismetti, MD, PhD:
Department of Therapeutic Medicine, CHU Saint-Etienne, Hôpital Nord, Saint-Etienne, France Thrombosis Research Group EA 3065, Jean Monnet University, Saint-Etienne, France Inserm, CIE3, F- 42055 Saint-Etienne, France Phone.: +33 477 828 355 3 Page 3 of 25
Email: [email protected]
ip t
Corresponding author: Claire Boutet
cr
University Hospital of Saint Etienne, Hôpital Nord,
us
42055 Saint Etienne Cedex 2 Phone.: +33 477 828 355
an
Fax: +33 477 120 547
Ac ce p
te
d
M
Email: [email protected]
4 Page 4 of 25
ABSTRACT Purpose: To compare magnetic resonance imaging (MRI) brain feature in cryptogenic stroke patients with patent foramen ovale (PFO), cryptogenic stroke patients without PFO and
ip t
patients with cardioembolic stroke. Materials and methods: The ethics committee required neither institutional review board
cr
approval nor informed patient consent for retrospective analyses of the patients' medical
us
records and imaging data. The patients' medical files were retrospectively reviewed in accordance with human subject research protocols. Ninety-two patients under 60 years of age
an
were included; 15 with cardioembolic stroke, 32 with cryptogenic stroke with PFO and 45 with cryptogenic stroke without PFO. Diffusion-weighted imaging of brain MRI was
M
performed by a radiologist blinded to clinical data. Univariate, Fischer’s exact test for qualitative data and non-parametric Wilcoxon test for quantitative data were used.
d
Results: There was no statistically significant difference found between MRI features of
te
patients with PFO and those with cardioembolic stroke (p
