Accepted Manuscript BRAF V600E mutations: a series of case reports in patients with non-small cell lung cancer Jamie M. Goldman, MD, Jhanelle E. Gray, MD PII:
S2210-7762(15)00043-5
DOI:
10.1016/j.cancergen.2015.04.001
Reference:
CGEN 376
To appear in:
Cancer Genetics
Received Date: 8 August 2014 Revised Date:
31 March 2015
Accepted Date: 1 April 2015
Please cite this article as: Goldman JM, Gray JE, BRAF V600E mutations: a series of case reports in patients with non-small cell lung cancer, Cancer Genetics (2015), doi: 10.1016/j.cancergen.2015.04.001. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT 1 BRIEF COMMUNICATION BRAF V600E mutations: a series of case reports in patients with non-small cell lung cancer
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Jamie M. Goldman, MD1 Jhanelle E. Gray, MD2 1
University of South Florida, Department of Internal Medicine, Tampa, FL Department of Thoracic Oncology, Moffitt Cancer Center, Tampa, FL
2
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Corresponding author: Jhanelle Gray, MD, 12902 Magnolia Drive, FOB1, Tampa, FL 33612. Ph: 813-7456895; Fax: 813-745-3027; Email: [email protected]
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Word count: (includes abstract/tables/text /references) 2355 2 tables, 0 figures
ACCEPTED MANUSCRIPT 2
ABSTRACT Here, we present a series of five patients with BRAF-mutated non-small cell lung cancer
RI PT
(NSCLC) from the Moffitt Cancer Center and a brief literature review. Information utilized included outside medical records, imaging studies, pathology reports in which simultaneous mutation testing was performed, and clinic visit notes. In addition, we conducted a literature
SC
search of background information using the following search terms: BRAF mutations, nonsmall cell lung cancer, and driver mutations. Several retrospective studies have been done on
M AN U
BRAF mutations in patients with NSCLC, which found that the majority occurs in adenocarcinomas and are V600E mutations. From our patients and literature search, we found that BRAF-V600E mutations are shown more predominantly in female smokers with
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EP
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adenocarcinomas.
ACCEPTED MANUSCRIPT 3 INTRODUCTION Lung cancer remains one of the leading causes of cancer death worldwide, with 85% of these due to non-small cell lung cancer (NSCLC) [1-6]. Aside from the more common EGFR and
RI PT
KRAS mutations found in NSCLC, BRAF mutations occur in
S2210-7762(15)00043-5
DOI:
10.1016/j.cancergen.2015.04.001
Reference:
CGEN 376
To appear in:
Cancer Genetics
Received Date: 8 August 2014 Revised Date:
31 March 2015
Accepted Date: 1 April 2015
Please cite this article as: Goldman JM, Gray JE, BRAF V600E mutations: a series of case reports in patients with non-small cell lung cancer, Cancer Genetics (2015), doi: 10.1016/j.cancergen.2015.04.001. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT 1 BRIEF COMMUNICATION BRAF V600E mutations: a series of case reports in patients with non-small cell lung cancer
RI PT
Jamie M. Goldman, MD1 Jhanelle E. Gray, MD2 1
University of South Florida, Department of Internal Medicine, Tampa, FL Department of Thoracic Oncology, Moffitt Cancer Center, Tampa, FL
2
M AN U
SC
Corresponding author: Jhanelle Gray, MD, 12902 Magnolia Drive, FOB1, Tampa, FL 33612. Ph: 813-7456895; Fax: 813-745-3027; Email: [email protected]
AC C
EP
TE D
Word count: (includes abstract/tables/text /references) 2355 2 tables, 0 figures
ACCEPTED MANUSCRIPT 2
ABSTRACT Here, we present a series of five patients with BRAF-mutated non-small cell lung cancer
RI PT
(NSCLC) from the Moffitt Cancer Center and a brief literature review. Information utilized included outside medical records, imaging studies, pathology reports in which simultaneous mutation testing was performed, and clinic visit notes. In addition, we conducted a literature
SC
search of background information using the following search terms: BRAF mutations, nonsmall cell lung cancer, and driver mutations. Several retrospective studies have been done on
M AN U
BRAF mutations in patients with NSCLC, which found that the majority occurs in adenocarcinomas and are V600E mutations. From our patients and literature search, we found that BRAF-V600E mutations are shown more predominantly in female smokers with
AC C
EP
TE D
adenocarcinomas.
ACCEPTED MANUSCRIPT 3 INTRODUCTION Lung cancer remains one of the leading causes of cancer death worldwide, with 85% of these due to non-small cell lung cancer (NSCLC) [1-6]. Aside from the more common EGFR and
RI PT
KRAS mutations found in NSCLC, BRAF mutations occur in
