Accepted Manuscript Body Composition Is Associated With Multisite Lower Body Musculoskeletal Pain In a Community-based Study Sharmayne R.E. Brady, BMedSc (Hons), MBBS (Hons), FRACP, Bambino B. Mamuaya, BMedSc(Hons), Flavia Cicuttini, MBBS, FRACP, PhD, Anita E. Wluka, MBBS, FRACP, PhD, Yuanyuan Wang, MD, PhD, Sultana Monira Hussain, MBBS, MPH, Donna M. Urquhart, BPhysio, PhD PII:
S1526-5900(15)00642-2
DOI:
10.1016/j.jpain.2015.04.006
Reference:
YJPAI 3080
To appear in:
Journal of Pain
Received Date: 11 November 2014 Revised Date:
19 March 2015
Accepted Date: 17 April 2015
Please cite this article as: Brady SRE, Mamuaya BB, Cicuttini F, Wluka AE, Wang Y, Hussain SM, Urquhart DM, Body Composition Is Associated With Multisite Lower Body Musculoskeletal Pain In a Community-based Study, Journal of Pain (2015), doi: 10.1016/j.jpain.2015.04.006. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
1
ACCEPTED MANUSCRIPT
Body Composition Is Associated With Multisite Lower Body Musculoskeletal Pain In a Community-based Study Sharmayne R.E. Brady1 (BMedSc (Hons), MBBS (Hons), FRACP), Bambino B. Mamuaya1
RI PT
(BMedSc(Hons)), Flavia Cicuttini1 (MBBS, FRACP, PhD), Anita E. Wluka1 (MBBS, FRACP, PhD), Yuanyuan Wang1 (MD, PhD), Sultana Monira Hussain1 (MBBS, MPH), Donna M. Urquhart1 (BPhysio, PhD)
Department of Epidemiology and Preventive Medicine, School of Public Health and
SC
1
M AN U
Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia S.R.E.B. and B.B.M. are co-first authors
Disclosures
TE D
S.R.E.B. was supported by a NHMRC Clinical Postgraduate Research scholarship (#1074979). A.E.W., Y. W., and D.M.U. are the recipients of NHMRC Career Development Fellowships (Clinical Level 2 #1063574, Clinical Level 1 #1065464, and Clinical Level 1 #1011975,
EP
respectively). All authors made significant contributions to the manuscript. There are no
AC C
conflicts of interest to disclose.
Address correspondence to:
Dr Donna Urquhart, Department of Epidemiology and
Preventive Medicine, School of Public Health and Preventive Medicine, Monash University The Alfred Centre, 99 Commercial Rd Melbourne 3004, Victoria, AUSTRALIA Ph: 9903 0555 Fax: 9903 0556 Email: [email protected]
2
ACCEPTED MANUSCRIPT Abstract
Population-based studies suggest that pain in the lower body is common, and that pain at multiple sites is more prevalent than single site pain. Obesity is a risk factor for multisite
RI PT
musculoskeletal pain, but there are limited data on the role of body composition. Therefore, we determined whether body composition is associated with multisite musculoskeletal pain, involving the lower back, knee and foot. 133 participants were recruited for a study
SC
examining the relationship between obesity and musculoskeletal disease. Participants completed validated questionnaires which examined levels of pain at the low back, knee
M AN U
and foot. Body composition was assessed using dual energy x-ray absorptiometry. Multisite pain was common, with 26.3% of participants reporting pain at two sites, 31.6% at three sites and only 20% were pain free. The lower back was the most common site of pain (63%). Increasing fat mass and fat mass index, but not fat free mass, was associated with pain at a
TE D
greater number of sites, independent of age, gender and fat free mass (p
S1526-5900(15)00642-2
DOI:
10.1016/j.jpain.2015.04.006
Reference:
YJPAI 3080
To appear in:
Journal of Pain
Received Date: 11 November 2014 Revised Date:
19 March 2015
Accepted Date: 17 April 2015
Please cite this article as: Brady SRE, Mamuaya BB, Cicuttini F, Wluka AE, Wang Y, Hussain SM, Urquhart DM, Body Composition Is Associated With Multisite Lower Body Musculoskeletal Pain In a Community-based Study, Journal of Pain (2015), doi: 10.1016/j.jpain.2015.04.006. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
1
ACCEPTED MANUSCRIPT
Body Composition Is Associated With Multisite Lower Body Musculoskeletal Pain In a Community-based Study Sharmayne R.E. Brady1 (BMedSc (Hons), MBBS (Hons), FRACP), Bambino B. Mamuaya1
RI PT
(BMedSc(Hons)), Flavia Cicuttini1 (MBBS, FRACP, PhD), Anita E. Wluka1 (MBBS, FRACP, PhD), Yuanyuan Wang1 (MD, PhD), Sultana Monira Hussain1 (MBBS, MPH), Donna M. Urquhart1 (BPhysio, PhD)
Department of Epidemiology and Preventive Medicine, School of Public Health and
SC
1
M AN U
Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia S.R.E.B. and B.B.M. are co-first authors
Disclosures
TE D
S.R.E.B. was supported by a NHMRC Clinical Postgraduate Research scholarship (#1074979). A.E.W., Y. W., and D.M.U. are the recipients of NHMRC Career Development Fellowships (Clinical Level 2 #1063574, Clinical Level 1 #1065464, and Clinical Level 1 #1011975,
EP
respectively). All authors made significant contributions to the manuscript. There are no
AC C
conflicts of interest to disclose.
Address correspondence to:
Dr Donna Urquhart, Department of Epidemiology and
Preventive Medicine, School of Public Health and Preventive Medicine, Monash University The Alfred Centre, 99 Commercial Rd Melbourne 3004, Victoria, AUSTRALIA Ph: 9903 0555 Fax: 9903 0556 Email: [email protected]
2
ACCEPTED MANUSCRIPT Abstract
Population-based studies suggest that pain in the lower body is common, and that pain at multiple sites is more prevalent than single site pain. Obesity is a risk factor for multisite
RI PT
musculoskeletal pain, but there are limited data on the role of body composition. Therefore, we determined whether body composition is associated with multisite musculoskeletal pain, involving the lower back, knee and foot. 133 participants were recruited for a study
SC
examining the relationship between obesity and musculoskeletal disease. Participants completed validated questionnaires which examined levels of pain at the low back, knee
M AN U
and foot. Body composition was assessed using dual energy x-ray absorptiometry. Multisite pain was common, with 26.3% of participants reporting pain at two sites, 31.6% at three sites and only 20% were pain free. The lower back was the most common site of pain (63%). Increasing fat mass and fat mass index, but not fat free mass, was associated with pain at a
TE D
greater number of sites, independent of age, gender and fat free mass (p
