Clinical Endocrinology (1992) 37,426-431
Body composition and bone mass in post-menopausal women J. E. Compston', M. Bhambhanit, M. A. LaskeyS, S. Murphy§ and K. T. Khaws 'Department of Medicine, University of Cambridge Clinical School and Departments of TRheumatology, muclear Medicine and §Clinical Gerontology, Addenbrooke's Hospital, Hills Road, Cambridge C 6 2 2 0 0 , UK (Received 13 March 7992; returned for revision 27 April 1992; finally revised 8 June 1992; accepted 26 June 1992)
Summary OBJECTIVE We almed to assess total body composition
and to study the lnterrelatlonshlps between fat and lean tissue mass with total and regional bone mass in healthy British post-menopausal women. DESIGN AND PATIENTS Total body composition and regional bone mass were measured In 97 healthy postmenopausal women recruited from the general community. The mean age was 57.9 years, range 49-65. MEASUREMENTS Total body composition (fat, lean tissue and bone mineral)and regional bone density In the lumbar spine and femur were measured by dual energy X-ray absorptlometry on a Lunar DPX. RESULTS significant negative correlations wlth age were found for total body bone mineral denslty (r= -0.200, P=O-O49), and lumbar spine bone mlneral density (r = - 0.28, P =0.006); the calculated rate of bone loss from these two sites was 0.33 and 0.7% per annum respectively. Fat tissue mass showed a positive correlation wlth age (r = 0.22, P = 0.03). High correlations were observed between total body and regional bone mineral density (r = 0.755-0.829, P c 0.001). After adjustment for age and lean mass, statlstlcally significant correlatlons were seen between fat tissue mass and all bone mass measurements (P < 0.01-0.001), the strongest correlatlons belng found for total body bone mineral content and denslty (r = 0.477 and 0.488 respectively). Lean tissue mass showed a strong
Correspondence: Dr J. E. Compston, Department of Medicine, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 ZQQ, UK 426
correlatlon wlth total body bone mineral content (r = 0.580, P
Body composition and bone mass in post-menopausal women J. E. Compston', M. Bhambhanit, M. A. LaskeyS, S. Murphy§ and K. T. Khaws 'Department of Medicine, University of Cambridge Clinical School and Departments of TRheumatology, muclear Medicine and §Clinical Gerontology, Addenbrooke's Hospital, Hills Road, Cambridge C 6 2 2 0 0 , UK (Received 13 March 7992; returned for revision 27 April 1992; finally revised 8 June 1992; accepted 26 June 1992)
Summary OBJECTIVE We almed to assess total body composition
and to study the lnterrelatlonshlps between fat and lean tissue mass with total and regional bone mass in healthy British post-menopausal women. DESIGN AND PATIENTS Total body composition and regional bone mass were measured In 97 healthy postmenopausal women recruited from the general community. The mean age was 57.9 years, range 49-65. MEASUREMENTS Total body composition (fat, lean tissue and bone mineral)and regional bone density In the lumbar spine and femur were measured by dual energy X-ray absorptlometry on a Lunar DPX. RESULTS significant negative correlations wlth age were found for total body bone mineral denslty (r= -0.200, P=O-O49), and lumbar spine bone mlneral density (r = - 0.28, P =0.006); the calculated rate of bone loss from these two sites was 0.33 and 0.7% per annum respectively. Fat tissue mass showed a positive correlation wlth age (r = 0.22, P = 0.03). High correlations were observed between total body and regional bone mineral density (r = 0.755-0.829, P c 0.001). After adjustment for age and lean mass, statlstlcally significant correlatlons were seen between fat tissue mass and all bone mass measurements (P < 0.01-0.001), the strongest correlatlons belng found for total body bone mineral content and denslty (r = 0.477 and 0.488 respectively). Lean tissue mass showed a strong
Correspondence: Dr J. E. Compston, Department of Medicine, Level 5, Addenbrooke's Hospital, Hills Road, Cambridge CB2 ZQQ, UK 426
correlatlon wlth total body bone mineral content (r = 0.580, P
