Therapeutics Systematic review and meta-analysis
Blood pressure reduction in elderly patients with hypertension decreases risk of adverse cardiovascular outcomes 10.1136/eb-2014-101778 Sripal Bangalore,1 Bethany Doran2 1
Division of Cardiology, New York School of Medicine, New York, New York, USA 2New York School of Medicine, New York, New York, USA Correspondence to: Dr Sripal Bangalore, Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA; [email protected]
Commentary on: Briasoulis A, Agarwal V, Tousoulis D, et al. Effects of antihypertensive treatment in patients over 65 years of age: a meta-analysis of randomised controlled studies. Heart 2014;100:317–23.
Context In individuals over 65-years old, uncontrolled hypertension has been associated with increased risk of stroke, as well as all-cause and cardiovascular death.1–3 However, optimal blood pressure (BP) targets in the elderly remain uncertain.4 Briasoulis and colleagues examine the effect of antihypertensive treatment on outcomes in individuals over the age of 65.
Methods This systematic review of 18 randomised trials enrolled patients aged over 65 with hypertension. Trials were divided into two subgroups: group 1 compared antihypertensive treatment to placebo, while group 2 compared two antihypertensive treatment groups. Outcomes included allcause mortality, cardiovascular mortality, stroke and heart failure. A total of 59 285 controls and 55 569 patients with hypertension were included, with an average follow-up of 3.44 years and mean age of 71.04 years. Standard meta-analytic techniques generated summary OR with 95% CI.
support systolic blood pressure lowering at a level of
Blood pressure reduction in elderly patients with hypertension decreases risk of adverse cardiovascular outcomes 10.1136/eb-2014-101778 Sripal Bangalore,1 Bethany Doran2 1
Division of Cardiology, New York School of Medicine, New York, New York, USA 2New York School of Medicine, New York, New York, USA Correspondence to: Dr Sripal Bangalore, Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA; [email protected]
Commentary on: Briasoulis A, Agarwal V, Tousoulis D, et al. Effects of antihypertensive treatment in patients over 65 years of age: a meta-analysis of randomised controlled studies. Heart 2014;100:317–23.
Context In individuals over 65-years old, uncontrolled hypertension has been associated with increased risk of stroke, as well as all-cause and cardiovascular death.1–3 However, optimal blood pressure (BP) targets in the elderly remain uncertain.4 Briasoulis and colleagues examine the effect of antihypertensive treatment on outcomes in individuals over the age of 65.
Methods This systematic review of 18 randomised trials enrolled patients aged over 65 with hypertension. Trials were divided into two subgroups: group 1 compared antihypertensive treatment to placebo, while group 2 compared two antihypertensive treatment groups. Outcomes included allcause mortality, cardiovascular mortality, stroke and heart failure. A total of 59 285 controls and 55 569 patients with hypertension were included, with an average follow-up of 3.44 years and mean age of 71.04 years. Standard meta-analytic techniques generated summary OR with 95% CI.
support systolic blood pressure lowering at a level of
