www.nature.com/scientificreports
OPEN
received: 20 November 2015 accepted: 31 January 2017 Published: 09 March 2017
Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy Hong-Yu Long1,*, Li Feng1,*, Jin Kang1, Zhao-Hui Luo1, Wen-Biao Xiao1, Li-Li Long1, Xiao-Xin Yan2,3, Luo Zhou1 & Bo Xiao1 Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder; little is known whether it is associated with peripheral epigenetic changes. Here we compared blood whole genomic DNA methylation pattern in MTLE patients (n = 30) relative to controls (n = 30) with the Human Methylation 450 K BeadChip assay, and explored genes and pathways that were differentially methylated using bioinformatics profiling. The MTLE and control groups showed significantly different (P
OPEN
received: 20 November 2015 accepted: 31 January 2017 Published: 09 March 2017
Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy Hong-Yu Long1,*, Li Feng1,*, Jin Kang1, Zhao-Hui Luo1, Wen-Biao Xiao1, Li-Li Long1, Xiao-Xin Yan2,3, Luo Zhou1 & Bo Xiao1 Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder; little is known whether it is associated with peripheral epigenetic changes. Here we compared blood whole genomic DNA methylation pattern in MTLE patients (n = 30) relative to controls (n = 30) with the Human Methylation 450 K BeadChip assay, and explored genes and pathways that were differentially methylated using bioinformatics profiling. The MTLE and control groups showed significantly different (P
