Original research
Multiple sensitivity phenotype in interstitial cystitis/bladder pain syndrome Michael B. Fuoco, MD; Karen Irvine-Bird, MD; J. Curtis Nickel, MD, FRCSC Department of Urology, Queen’s University, Kingston, ON
Cite as: Can Urol Assoc J 2014;8(11-12):e758-61. http://dx.doi.org/10.5489/cuaj.2031 Published online November 24, 2014.
Abstract Introduction: Phenotypic differentiation of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) may improve our understanding of the condition, as well as the development of patientspecific treatment strategies. We identified a distinct subgroup of IC/BPS patients with a multiple sensitivity phenotype. Methods: We defined patients with this IC/BPS associated multiple sensitivity syndrome as having at least 3 confirmed allergies/sensitivities to medications and/or environmental factors and a diagnosis of IC/BPS. These IC/BPS patients identified with a multiple sensitivity phenotype (cases) were compared to agematched IC/BPS patients with few or no allergies (controls) at a 1:2 ratio. Comparisons were undertaken using standardized case assessment parameters (age, duration of symptoms, medical history, Interstitial Cystitis Symptoms Index [ICSI] and pelvic pain and urinary urgency/frequency [PUF] symptom scores, and urinary, psychosocial, organ specific, infection, neurologic/systemic, tenderness [UPOINT] categorization). Results: The study consisted of 17 cases and 34 age-matched controls; the mean age was 55 and 56 years, respectively. There was statistically more medication and environmental allergies in the cases versus controls. Cases reported more concomitant illnesses (9.6 vs. 6.2, p
Multiple sensitivity phenotype in interstitial cystitis/bladder pain syndrome Michael B. Fuoco, MD; Karen Irvine-Bird, MD; J. Curtis Nickel, MD, FRCSC Department of Urology, Queen’s University, Kingston, ON
Cite as: Can Urol Assoc J 2014;8(11-12):e758-61. http://dx.doi.org/10.5489/cuaj.2031 Published online November 24, 2014.
Abstract Introduction: Phenotypic differentiation of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) may improve our understanding of the condition, as well as the development of patientspecific treatment strategies. We identified a distinct subgroup of IC/BPS patients with a multiple sensitivity phenotype. Methods: We defined patients with this IC/BPS associated multiple sensitivity syndrome as having at least 3 confirmed allergies/sensitivities to medications and/or environmental factors and a diagnosis of IC/BPS. These IC/BPS patients identified with a multiple sensitivity phenotype (cases) were compared to agematched IC/BPS patients with few or no allergies (controls) at a 1:2 ratio. Comparisons were undertaken using standardized case assessment parameters (age, duration of symptoms, medical history, Interstitial Cystitis Symptoms Index [ICSI] and pelvic pain and urinary urgency/frequency [PUF] symptom scores, and urinary, psychosocial, organ specific, infection, neurologic/systemic, tenderness [UPOINT] categorization). Results: The study consisted of 17 cases and 34 age-matched controls; the mean age was 55 and 56 years, respectively. There was statistically more medication and environmental allergies in the cases versus controls. Cases reported more concomitant illnesses (9.6 vs. 6.2, p
