Acta Neuropathol DOI 10.1007/s00401-015-1435-y

ORIGINAL PAPER

Beta‑amyloid deposition in chronic traumatic encephalopathy Thor D. Stein1,2,3,4 · Philip H. Montenigro3,5 · Victor E. Alvarez3,6 · Weiming Xia2 · John F. Crary7,8,9 · Yorghos Tripodis10,11 · Daniel H. Daneshvar3,6 · Jesse Mez3,6 · Todd Solomon3,6 · Gaoyuan Meng1 · Caroline A. Kubilus3,6 · Kerry A. Cormier3,6 · Steven Meng3 · Katharine Babcock3 · Patrick Kiernan3,6 · Lauren Murphy3,6 · Christopher J. Nowinski3,12 · Brett Martin3,11 · Diane Dixon3,11 · Robert A. Stern3,5,6,13 · Robert C. Cantu5,12,13,14 · Neil W. Kowall1,3,6 · Ann C. McKee1,2,3,4,6  Received: 30 January 2015 / Revised: 22 April 2015 / Accepted: 23 April 2015 © Springer-Verlag Berlin Heidelberg (outside the USA) 2015

Abstract  Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild traumatic brain injury. It is defined pathologically by the abnormal accumulation of tau in a unique pattern that is distinct from other tauopathies, including Alzheimer’s disease (AD). Although trauma has been suggested to increase amyloid β peptide (Aβ) levels, the extent of Aβ deposition in CTE has not been thoroughly characterized. We studied a heterogeneous cohort of deceased athletes and military veterans with neuropathologically diagnosed CTE (n  = 114, mean age at death = 60) to test the hypothesis that Aβ

deposition is altered in CTE and associated with more severe pathology and worse clinical outcomes. We found that Aβ deposition, either as diffuse or neuritic plaques, was present in 52 % of CTE subjects. Moreover, Aβ deposition in CTE occurred at an accelerated rate and with altered dynamics in CTE compared to a normal aging population (OR  = 3.8, p 

Beta-amyloid deposition in chronic traumatic encephalopathy.

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild traumatic brain injury. It is defined pathologic...
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