Support Care Cancer DOI 10.1007/s00520-014-2547-y
ORIGINAL ARTICLE
Awareness of the adverse effects associated with prophylactic corticosteroid use during docetaxel therapy Ka-Eun Yoo & Rae Young Kang & Ju-Yeun Lee & Yu Jeung Lee & Sung Yun Suh & Kwi Suk Kim & Hyang Sook Kim & Se-Hoon Lee & Byung Koo Lee
Received: 15 July 2014 / Accepted: 30 November 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Purpose Weekly or tri-weekly docetaxel treatment mandates the use of dexamethasone to prevent toxicity. However, the adverse effects of prophylactic steroid use are often overlooked. We investigated the incidence of corticosteroidassociated adverse effects during docetaxel therapy, focusing on hyperglycemia and infection as well as the identification of possible risk factors. Methods This study was conducted through retrospective chart review of 632 patients who started docetaxel-based chemotherapy between July 2011 and June 2012 at Seoul National University Hospital. Hyperglycemia was defined as more than two random glucose levels >200 mg/dL. All
Ka-Eun Yoo and Rae Young Kang contributed equally to this work. K.
ORIGINAL ARTICLE
Awareness of the adverse effects associated with prophylactic corticosteroid use during docetaxel therapy Ka-Eun Yoo & Rae Young Kang & Ju-Yeun Lee & Yu Jeung Lee & Sung Yun Suh & Kwi Suk Kim & Hyang Sook Kim & Se-Hoon Lee & Byung Koo Lee
Received: 15 July 2014 / Accepted: 30 November 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Purpose Weekly or tri-weekly docetaxel treatment mandates the use of dexamethasone to prevent toxicity. However, the adverse effects of prophylactic steroid use are often overlooked. We investigated the incidence of corticosteroidassociated adverse effects during docetaxel therapy, focusing on hyperglycemia and infection as well as the identification of possible risk factors. Methods This study was conducted through retrospective chart review of 632 patients who started docetaxel-based chemotherapy between July 2011 and June 2012 at Seoul National University Hospital. Hyperglycemia was defined as more than two random glucose levels >200 mg/dL. All
Ka-Eun Yoo and Rae Young Kang contributed equally to this work. K.
