Case Report

Autosomal recessive bilateral frontal polymicrogyria with ectopia lentis and chorioretinal dystrophy Javeria Nooraine, Kemmanu Vasudha1, Sribhargava Natesh1, Rajesh B. Iyer, Seetharam Raghavendra Departments of Neurology, Vikram Hospital, 1Neuroophthalmology, Narayana Nethralaya, Bengaluru, India Abstract Polymicrogyria is a type of cortical dysplasia with cortical organizational defect. Bilateral polymicrogyria are distinct with genetic basis in a subset. We hereby report a case of bilateral frontal polymicrogyria (BFP) in association with chorioretinal dystrophy and ectopia lentis (EL) in a 26-year-old lady born of a consanguineous parentage. Her male sibling also had chorioretinal dystrophy and EL. This combination of autosomal recessive inheritance has not been reported earlier in the literature and suggests a role of connective tissue genes in BFP.

Key Words Autosomal recessive, chorioretinal-dystrophy, ectopia lentis, frontal-polymicrogyria For correspondence: Dr. S. Raghavendra, Department of Neurology, Vikram Hospital,

Bengaluru - 560 010, Karnataka, India. E-mail: [email protected] Ann Indian Acad Neurol 2013;16:678-80

Introduction Polymicrogyria is a type of cortical dysplasia due to cortical organizational defect. Bilateral polymicrogyria are distinct with genetic basis in a subset. We report bilateral frontal polymicrogyria (BFP) in association with chorioretinal dystrophy and ectopia lentis (EL) of presumable autosomal recessive inheritance.

Case Reports Patient 1 A 26-year-old female presented with epilepsy from 7 years of age. She also had a reduced vision from early childhood. Her initial generalized tonic clonic seizures later evolved as brief tonic right upper limb posturing suggestive of mesial frontal originating seizures. Magnetic resonance imaging (MRI) brain revealed BFP [Figure 1a-c]. EEG showed left parasagittal central-frontal spikes without focal slowing. Seizures were controlled on a combination of carbamazepine and clobazam. Access this article online Quick Response Code:

Website: www.annalsofian.org

DOI: 10.4103/0972-2327.120473

She was born of second degree consanguineous parentage. Her antenatal, natal, and immediate postnatal periods were normal. There was a mild global delay in achieving some of her milestones. She completed her schooling with an average performance. There was no family history of similar illness in up to three generations other than her brother who had similar visual problems. She had marfanoid body habitus. Head circumference was 54.5 cm, height 171 cm, and arm-span 177 cm. No skeletal or spinal deformities were evident. Cognitive skills were average without problems for routine daily activities. Neurologically, eye movements were normal. No focal neurological deficits were evident. Other systemic examination was normal. Uncorrected visual acuity was counting finger close to face bilaterally. Slit lamp examination revealed infero-temporal subluxation of the lens in the right eye [Figure 1d, e and f]. Indirect ophthalmoscopy showed attached retina with optic disc pallor. There was diffuse retinal pigment epithelium (RPE) atrophy with tessellated background, arteriolar attenuation, and choroidal sclerosis in both the eyes [Figure 1g]. There were no RPE clumps or bony spicules. At 3 weeks review, the previously subluxed lens in the right eye had dislocated into the vitreous. Full field electroretinogram (ERG) showed reduced amplitude of scotopic (75-80%) and photopic responses (60-70%). Hemogram, renal and liver functions, serum homocysteine, arterial blood gas, ammonia, lactate, aminoacidogram (urine and serum), ultrasonography of abdomen, electrocardiogram and echocardiography were normal.

Annals of Indian Academy of Neurology, October-December 2013, Vol 16, Issue 4

Nooraine, et al.: Autosomal recessive frontal polymicrogyria, ectopia lentis and chorioretinal dystrophy679

a

d

e

b

c

g

i

BFP is characterized by symmetrical frontal polymicrogyria extending up to the precentral gyrus and the sylvian fissure.[1] Common clinical features include delayed milestones, mild to moderate mental retardation and bilateral pyramidal signs. In our patient, seizures and mild developmental delay without pyramidal signs were noted. The white matter on MRI also appeared normal. Associated with this BFP were chorioretinal dystrophy and EL. Similar ocular findings without polymicrogyria were observed in her sibling. Interand intra-family variability in familial perisylvian syndrome has been described earlier.[2]

f h

Figure 1: (a-c) T1 axial and sagittal magnetic resonance imaging (MRI) of a 26-year-old lady with seizures showing bilateral frontal polymicrogyria without any additional abnormality. (d and e) MRI demonstrating the partial infero-temporal lens dislocation on the right side in comparison to the left. (f) Slit lamp photograph of the anterior segment of the right eye showing the inferotemporal subluxation of lens (the arrows point to the superior edge of the lens). (g) Fundus photograph of the patient showing pale disc and chorioretinal dystrophy. (h and i) MRI of the sibling showing ectopia lentis bilaterally (the arrows show the lens in the vitreous cavity) and mild diffuse cerebral atrophy but no polymicrogyria

Patient 2 Elder brother of proband, aged 28 years, also had reduced vision from early childhood. His development too was mildly delayed. He never had seizures or systemic symptoms. He had marfanoid body habitus without skeletal or spinal deformities. Head circumference was 59 cm, height 178 cm, and arm-span 182 cm. His best corrected visual acuity was counting fingers at 2 m in both the eyes. Slit lamp examination revealed bilateral aphakia. Fundus findings were similar to his sister consistent with chorioretinal dystrophy. On full-field ERG scotopic response was not recordable and photopic response showed 80% amplitude reduction. Hemogram, liver and renal functions, arterial blood gas, serum lactate, homocysteine, and ammonia were normal. MRI showed a mild cortical, cerebellar and brainstem atrophy with dislocated lens bilaterally [Figure 1h and i]. The parents of the proband were normal, including hemogram, and biochemistry.

Discussion We report here BFP, chorio-retinal dystrophy and EL in a patient with likely autosomal recessive inheritance. Polymicrogyria is a type of cortical dysplasia with abnormal cortical organization of the neurons. Bilateral polymicrogyria are distinct and may have a heritable basis. This group includes bilateral frontal, frontoparietal, parasagittal, perisylvian and occipital polymicrogyria syndromes.

Polymicrogyria syndromes are genetically heterogeneous. Autosomal recessive forms of generalized polymicrogyria have been earlier described.[3] Two of the 13 patients described by Guerrini et al., also had consanguinity suggesting an autosomal recessive inheritance.[1] However, there are no reports of these ocular abnormalities in association with BFP. The molecular basis of polymicrogyria is beginning to be elucidated with the identification of a gene GPR56 and its mechanism responsible for bilateral fronto-parietal polymicrogyria.[4] Chromosome 16q12-21 has also been linked to bilateral fronto-parietal polymicrogyria.[5,6] EL is heterogeneous and seen in a wide variety of systemic disorders associated with either structural or functional deficiencies of zonular ligaments. Marfan’s syndrome remains the commonest condition for heritable EL. The inheritance is autosomal dominant and very rarely recessive.[7] The lens dislocation in the proband was asymmetrical and inferotemporal, unlike Marfan’s where dislocation is bilaterally symmetrical and superior temporal. Also, cardiovascular and skeletal markers of Marfan’s syndrome were absent. Association of the rod-cone dystrophy with Marfan’s is unknown. Homocystinuria was ruled out by normal serum and urine homocysteine levels. No thromboembolic symptoms were noted. Sulfite oxidase deficiency is a rare disorder associated with very early progressive neurological dysfunction with EL especially within 1 year of life. Hyperlysinemia was ruled out by normal aminoacidogram. Ehler Danlos syndrome (EDS) can occasionally be associated with EL and rarely with BFP.[8] Our patient did not have the dermatological, joint, vascular features or cataract to suggest EDS. Weill-Marchesani syndrome is a rare connective tissue disorder either as autosomal dominant or recessive with short stature, brachydactyly, and EL.[9] Very few cases of autosomal recessive EL with hereditary chorioretinal disorders have been reported.[10,11] None of these patients either had seizures or focal cortical dysplasia. Recently, mutations in a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs-like (ADAMTSL-4) linked to chromosome 1q21 has been reported in autosomal recessive simple EL.[12] The ADAMTS super-family of proteins are important in cell migration, attachment and connective tissue organization.[13] Hypothetically, dysfunction of these proteins may lead to polymicrogyria.

Conclusion This patient highlights the probable role of connective tissue genes in pathogenesis of polymicrogyria.

Annals of Indian Academy of Neurology, October-December 2013, Vol 16, Issue 4

680

Nooraine, et al.: Autosomal recessive frontal polymicrogyria, ectopia lentis and chorioretinal dystrophy

References 1.

Guerrini R, Barkovich AJ, Sztriha L, Dobyns WB. Bilateral frontal polymicrogyria: A newly recognized brain malformation syndrome. Neurology 2000;54:909-13. 2. Guerreiro MM, Andermann E, Guerrini R, Dobyns WB, Kuzniecky R, Silver K, et al . Familial perisylvian polymicrogyria: A new familial syndrome of cortical maldevelopment. Ann Neurol 2000;48:39-48. 3. Chang BS, Piao X, Giannini C, Cascino GD, Scheffer I, Woods CG, et al. Bilateral generalized polymicrogyria (BGP): A distinct syndrome of cortical malformation. Neurology 2004;62:1722-8. 4. Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, et al. GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci 2008;28:5817-26. 5. Piao X, Basel-Vanagaite L, Straussberg R, Grant PE, Pugh EW, Doheny K, et al. An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21. Am J Hum Genet 2002;70:1028-33. 6. Chang BS, Piao X, Bodell A, Basel-Vanagaite L, Straussberg R, Dobyns WB, et al. Bilateral frontoparietal polymicrogyria: Clinical and radiological features in 10 families with linkage to chromosome 16. Ann Neurol 2003;53:596-60. 7. de Vries BB, Pals G, Odink R, Hamel BC. Homozygosity for a FBN1 missense mutation: Clinical and molecular evidence for recessive Marfan syndrome. Eur J Hum Genet 2007;15:930-5.

8. Echaniz-Laguna A, de Saint-Martin A, Lafontaine AL, Tasch E, Thomas P, Hirsh E, et al. Bilateral focal polymicrogyria in EhlersDanlos syndrome. Arch Neurol 2000;57:123-7. 9. Faivre L, Mégarbané A, Alswaid A, Zylberberg L, Aldohayan N, Campos-Xavier B, et al. Homozygosity mapping of a WeillMarchesani syndrome locus to chromosome 19p13.3-p13.2. Hum Genet 2002;110:366-70. 10. Sato H, Wada Y, Abe T, Kawamura M, Wakusawa R, Tamai M. Retinitis pigmentosa associated with ectopia lentis. Arch Ophthalmol 2002;120:852-4. 11. Noble KG, Bass S, Sherman J. Ectopia lentis, chorioretinal dystrophy and myopia. A new autosomal recessive syndrome. Doc Ophthalmol 1993;83:97-102. 12. Ahram D, Sato TS, Kohilan A, Tayeh M, Chen S, Leal S, et al. A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated ectopia lentis. Am J Hum Genet 2009;84:274-8. 13. Apte SS. A disintegrin-like and metalloprotease (reprolysintype) with thrombospondin type 1 motif (ADAMTS) superfamily: Functions and mechanisms. J Biol Chem 2009;284:31493-7. How to cite this article: Nooraine J, Vasudha K, Natesh S, Iyer RB, Raghavendra S. Autosomal recessive bilateral frontal polymicrogyria with ectopia lentis and chorioretinal dystrophy. Ann Indian Acad Neurol 2013;16:678-80. Received: 27-01-13, Revised: 21-04-13, Accepted: 26-05-13

Annals of Indian Academy of Neurology, October-December 2013, Vol 16, Issue 4

Source of Support: Nil, Conflict of Interest: Nil

Copyright of Annals of Indian Academy of Neurology is the property of Medknow Publications & Media Pvt. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.

Autosomal recessive bilateral frontal polymicrogyria with ectopia lentis and chorioretinal dystrophy.

Polymicrogyria is a type of cortical dysplasia with cortical organizational defect. Bilateral polymicrogyria are distinct with genetic basis in a subs...
1MB Sizes 1 Downloads 0 Views

Recommend Documents


[Hereditary ectopia lentis].
If not due to trauma, ectopia lentis is usually caused genetically. It is a main symptom of several syndromal disorders such as Marfan syndrome or homocystinuria. Also other connective tissue disorders convey an elevated risk for ectopia lentis. Isol

Images in clin medicine: Ectopia lentis.
A 31-year-old woman with Marfan's syndrome presented with amblyopia and a history of gradual bilateral vision loss over the previous 3 to 4 months. She had also had mild sensorineural hearing loss within the previous 2 weeks.

Trauma-Induced Bilateral Ectopia Lentis Diagnosed with Point-of-Care Ultrasound.
Ocular trauma and acute loss of vision are high-yield patient presentations that may benefit from the use of bedside ultrasound to aid in the diagnosis of a variety of vision-threatening problems.

Novel mutation in FBN1 causes ectopia lentis and varicose great saphenous vein in one Chinese autosomal dominant family.
To identify genetic defects in a Chinese family with ectopia lentis (EL) and varicose great saphenous vein (GSV) and to analyze the correlations between phenotype and genotype.

Molecular pathogenesis and management strategies of ectopia lentis.
Ectopia lentis (EL) is a condition that can either herald underlying systemic conditions, or be isolated. The recent expansion in the genetics of these conditions has furthered the understanding of the underlying molecular aetiology. It is becoming a