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doi:10.1111/jog.12439
J. Obstet. Gynaecol. Res. Vol. 40, No. 6: 1832, June 2014
Letter to the Editor
Authors’ reply: Prognostic significance of mean platelet volume in epithelial ovarian cancer Dear Editor, Platelet parameter, the mean platelet volume (MPV), is described as a potential marker of platelet reactivity and risk factor for cardiovascular diseases in many researches.1 However, the prognostic significance of MPV in malignant diseases such as ovarian cancer is still unclear. Stone et al.2 analyzed clinical data on 619 patients with epithelial ovarian cancer and found that survival rates were not associated with high MPV(defined as an MPV greater than either the median or the cut-off value (>10.4 fl). In order to evaluate the prognostic significance, we have detected the MPV value in 182 cases ovarian cancer patients and found no significant difference between ovarian cancer and control groups. Mean platelet volume value measurement is influenced by several factors including the method, the choice of anticoagulant, time interval of measurement and temperature at which MPV is analyzed. In our research, the MPV value was analyzed by an XE-2000 Hematology System using electronic impedance method at room temperature. Full blood sample was anticoagulated by K2-ethylenediaminetetraacetic acid (K2-EDTA) with measurement time interval ranging 60–120 min. There was no unified standard for the choice of anticoagulant and time interval. Some authors prefer high-concentration sodium citrate for less platelet swelling. Others used K2-EDTA and recommended a time interval of 60–90 min. Lance et al.3 found that an optimal stability was detected in K2-EDTA after
1832
120 min and in sodium citrate after 60 min, which resulted in a reference range of 7.2–10.8 fl for K2-EDTA and 6.1–9.5 fl for sodium citrate, respectively. The reference range of MPV in our research was 7.8–12.5 fl. The same measurement was used to evaluate MPV in the ovarian cancer group and control groups in this research. Although the MPV value in the ovarian cancer group was slightly higher than control groups, which probably indicated high platelet reactivity, the differences were insignificant. Further researches are needed to investigate the prognostic significance of MPV in cancerous diseases.
Disclosure We declare that we have no conflict of interest. Xue Gong Ma, Ying Mei Wang and Feng Xia Xue Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China
References 1. Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157–161. 2. Stone RL, Kharghan VA, Sood AK. Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med 2012; 366: 1840. 3. Lance MD, van Oerle R, Henskens YM, Marcus MA. Do we need time adjusted mean platelet volume measurements? Lab Hematol 2010; 16: 28–31.
© 2014 The Authors Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology
doi:10.1111/jog.12439
J. Obstet. Gynaecol. Res. Vol. 40, No. 6: 1832, June 2014
Letter to the Editor
Authors’ reply: Prognostic significance of mean platelet volume in epithelial ovarian cancer Dear Editor, Platelet parameter, the mean platelet volume (MPV), is described as a potential marker of platelet reactivity and risk factor for cardiovascular diseases in many researches.1 However, the prognostic significance of MPV in malignant diseases such as ovarian cancer is still unclear. Stone et al.2 analyzed clinical data on 619 patients with epithelial ovarian cancer and found that survival rates were not associated with high MPV(defined as an MPV greater than either the median or the cut-off value (>10.4 fl). In order to evaluate the prognostic significance, we have detected the MPV value in 182 cases ovarian cancer patients and found no significant difference between ovarian cancer and control groups. Mean platelet volume value measurement is influenced by several factors including the method, the choice of anticoagulant, time interval of measurement and temperature at which MPV is analyzed. In our research, the MPV value was analyzed by an XE-2000 Hematology System using electronic impedance method at room temperature. Full blood sample was anticoagulated by K2-ethylenediaminetetraacetic acid (K2-EDTA) with measurement time interval ranging 60–120 min. There was no unified standard for the choice of anticoagulant and time interval. Some authors prefer high-concentration sodium citrate for less platelet swelling. Others used K2-EDTA and recommended a time interval of 60–90 min. Lance et al.3 found that an optimal stability was detected in K2-EDTA after
1832
120 min and in sodium citrate after 60 min, which resulted in a reference range of 7.2–10.8 fl for K2-EDTA and 6.1–9.5 fl for sodium citrate, respectively. The reference range of MPV in our research was 7.8–12.5 fl. The same measurement was used to evaluate MPV in the ovarian cancer group and control groups in this research. Although the MPV value in the ovarian cancer group was slightly higher than control groups, which probably indicated high platelet reactivity, the differences were insignificant. Further researches are needed to investigate the prognostic significance of MPV in cancerous diseases.
Disclosure We declare that we have no conflict of interest. Xue Gong Ma, Ying Mei Wang and Feng Xia Xue Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China
References 1. Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157–161. 2. Stone RL, Kharghan VA, Sood AK. Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med 2012; 366: 1840. 3. Lance MD, van Oerle R, Henskens YM, Marcus MA. Do we need time adjusted mean platelet volume measurements? Lab Hematol 2010; 16: 28–31.
© 2014 The Authors Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology
