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窑Basic Research窑
Attenuation of corneal neovascularization by topical low-molecular-weight heparin-taurocholate 7 without bleeding complication
Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea 2 Department of Ophthalmology, Hanyang University College of Medicine, Seoul 04763, Korea Co-first authors: Jae Yong Kim and Soo Yeon Kim Correspondence to: Hungwon Tchah. Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnab-2dong, Songpa-gu, Seoul 05505, Korea. [email protected] Received: 2015-01-01 Accepted: 2015-12-08 1
·AIM: To investigate the antiangiogenic effects and safety of topically administered low -molecular-weight heparin taurocholate 7 (LHT7) on corneal neovascularization (CoNV). Twenty -four Sprague -Dawley rats were
randomly distributed into four groups of six rats each. The central corneas were cauterized using a silver/ potassium nitrate solution. From 2d after cauterization, 12.5 mg/mL (low LHT7 group) or 25 mg/mL (high LHT7 group) LHT7 was topically administered three times daily; 12.5 mg/mL bevacizumab was topically administered as positive control (bevacizumab) group, with normal saline (NS) administered as negative control (NS group). The corneas were digitally photographed to calculate the CoNV percentage from the neovascularized corneal area at 1 and 2wk.
· RESULTS:
The 4 study groups did not have different
CoNV percentages at 1wk after injury ( >0.05). However, the low LHT, high LHT, and bevacizumab groups had significantly lower CoNV percentages than the NS group at 2wk (all 0.05). All groups except the NS group had lower CoNV percentages at 2wk postinjury than the levels observed at 1wk (all
窑Basic Research窑
Attenuation of corneal neovascularization by topical low-molecular-weight heparin-taurocholate 7 without bleeding complication
Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea 2 Department of Ophthalmology, Hanyang University College of Medicine, Seoul 04763, Korea Co-first authors: Jae Yong Kim and Soo Yeon Kim Correspondence to: Hungwon Tchah. Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnab-2dong, Songpa-gu, Seoul 05505, Korea. [email protected] Received: 2015-01-01 Accepted: 2015-12-08 1
·AIM: To investigate the antiangiogenic effects and safety of topically administered low -molecular-weight heparin taurocholate 7 (LHT7) on corneal neovascularization (CoNV). Twenty -four Sprague -Dawley rats were
randomly distributed into four groups of six rats each. The central corneas were cauterized using a silver/ potassium nitrate solution. From 2d after cauterization, 12.5 mg/mL (low LHT7 group) or 25 mg/mL (high LHT7 group) LHT7 was topically administered three times daily; 12.5 mg/mL bevacizumab was topically administered as positive control (bevacizumab) group, with normal saline (NS) administered as negative control (NS group). The corneas were digitally photographed to calculate the CoNV percentage from the neovascularized corneal area at 1 and 2wk.
· RESULTS:
The 4 study groups did not have different
CoNV percentages at 1wk after injury ( >0.05). However, the low LHT, high LHT, and bevacizumab groups had significantly lower CoNV percentages than the NS group at 2wk (all 0.05). All groups except the NS group had lower CoNV percentages at 2wk postinjury than the levels observed at 1wk (all
