Sleep Breath (2015) 19:369–375 DOI 10.1007/s11325-014-1030-9
ORIGINAL ARTICLE
Attenuated macrophage cholesterol efflux function in patients with obstructive sleep apnea–hypopnea syndrome Rui-Yi Xu & Rong Huang & Yi Xiao & Lian-Feng Chen & Xue Lin & Quan Fang & Xiao-Wei Yan
Received: 3 March 2014 / Revised: 29 May 2014 / Accepted: 30 June 2014 / Published online: 8 July 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Background Obstructive sleep apnea–hypopnea syndrome (OSAHS) is associated with premature atherosclerosis. However, the associated mechanism remains unknown. This study investigates the expression of adenosine triphosphate (ATP)binding cassette transporter protein A1 (ABCA1) and cellular cholesterol efflux in cultured macrophages from OSAHS patients. Methods Of the 18 subjects enrolled in this study, six subjects with apnea–hypopnea index (AHI)
ORIGINAL ARTICLE
Attenuated macrophage cholesterol efflux function in patients with obstructive sleep apnea–hypopnea syndrome Rui-Yi Xu & Rong Huang & Yi Xiao & Lian-Feng Chen & Xue Lin & Quan Fang & Xiao-Wei Yan
Received: 3 March 2014 / Revised: 29 May 2014 / Accepted: 30 June 2014 / Published online: 8 July 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Background Obstructive sleep apnea–hypopnea syndrome (OSAHS) is associated with premature atherosclerosis. However, the associated mechanism remains unknown. This study investigates the expression of adenosine triphosphate (ATP)binding cassette transporter protein A1 (ABCA1) and cellular cholesterol efflux in cultured macrophages from OSAHS patients. Methods Of the 18 subjects enrolled in this study, six subjects with apnea–hypopnea index (AHI)
