HHS Public Access Author manuscript Author Manuscript
Stroke. Author manuscript; available in PMC 2017 June 01. Published in final edited form as: Stroke. 2016 June ; 47(6): 1486–1492. doi:10.1161/STROKEAHA.116.012865.
Atrial fibrillation is associated with a worse 90-day outcome than other cardioembolic stroke subtypes Nils Henninger, MDa,b,*, Richard P. Goddeau Jr., DOa, Ameeta Karmarkar, MDc, Johanna Helenius, MD, PhDa, and David D. McManus, M.D., Sc.M.d
Author Manuscript
aDepartment
of Neurology, University of Massachusetts Medical School, Worcester, MA
bDepartment
of Psychiatry, University of Massachusetts Medical School, Worcester, MA
cDepartment
of Internal Medicine, University of Massachusetts Medical School, Worcester, MA
dDivision
of Cardiology, University of Massachusetts Medical School, Worcester, MA
Abstract Background and Purpose—Patients with a cardioembolic stroke (CES) have worse outcomes than stroke patients with other causes of stroke. Among patients with CES, atrial fibrillation (AF) is a common comorbidity. Mounting data indicates that AF may relate to stroke pathogenesis beyond acute cerebral thromboembolism. We sought to determine whether AF represents an independent risk factor for stroke severity and outcome among patients with CES.
Author Manuscript
Methods—We retrospectively analyzed patients with acute hemispheric CES included in an academic medical center’s stroke registry. CES was determined using the Causative Classification System of ischemic stroke. Multivariable logistic regression was used to determine whether AF was associated with 90-day outcome functional status. Results—Our cohort included 140 patients. Of these, 52 had prevalent AF and 28 had incident AF diagnosed during their index hospitalization or within 90-days of hospital discharge. After adjustment for potential confounders or mediators, any AF (OR 2.51; 95%-CI 1.03–6.33; p=0.049), infarct volume (OR 1.03; 95%-CI 1.01–1.06; p=0.005), pre-admission mRS (OR 2.58; 95%-CI 1.66–4.01; p
Stroke. Author manuscript; available in PMC 2017 June 01. Published in final edited form as: Stroke. 2016 June ; 47(6): 1486–1492. doi:10.1161/STROKEAHA.116.012865.
Atrial fibrillation is associated with a worse 90-day outcome than other cardioembolic stroke subtypes Nils Henninger, MDa,b,*, Richard P. Goddeau Jr., DOa, Ameeta Karmarkar, MDc, Johanna Helenius, MD, PhDa, and David D. McManus, M.D., Sc.M.d
Author Manuscript
aDepartment
of Neurology, University of Massachusetts Medical School, Worcester, MA
bDepartment
of Psychiatry, University of Massachusetts Medical School, Worcester, MA
cDepartment
of Internal Medicine, University of Massachusetts Medical School, Worcester, MA
dDivision
of Cardiology, University of Massachusetts Medical School, Worcester, MA
Abstract Background and Purpose—Patients with a cardioembolic stroke (CES) have worse outcomes than stroke patients with other causes of stroke. Among patients with CES, atrial fibrillation (AF) is a common comorbidity. Mounting data indicates that AF may relate to stroke pathogenesis beyond acute cerebral thromboembolism. We sought to determine whether AF represents an independent risk factor for stroke severity and outcome among patients with CES.
Author Manuscript
Methods—We retrospectively analyzed patients with acute hemispheric CES included in an academic medical center’s stroke registry. CES was determined using the Causative Classification System of ischemic stroke. Multivariable logistic regression was used to determine whether AF was associated with 90-day outcome functional status. Results—Our cohort included 140 patients. Of these, 52 had prevalent AF and 28 had incident AF diagnosed during their index hospitalization or within 90-days of hospital discharge. After adjustment for potential confounders or mediators, any AF (OR 2.51; 95%-CI 1.03–6.33; p=0.049), infarct volume (OR 1.03; 95%-CI 1.01–1.06; p=0.005), pre-admission mRS (OR 2.58; 95%-CI 1.66–4.01; p
