ORIGINAL ARTICLE EPIDEMIOLOGY AND ASTHMA
Asthma, airflow limitation and mortality risk in the general population Shuang Huang1,2, Monica M. Vasquez1,2, Marilyn Halonen1, Fernando D. Martinez1 and Stefano Guerra1,3 Affiliations: 1Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA. 2Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA. 3CREAL Centre, CIBERESP, Universitat Pompeu Fabra, Barcelona, Spain. Correspondence: Stefano Guerra, Arizona Respiratory Center, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724-5030, USA. E-mail: [email protected]
ABSTRACT Asthma and chronic obstructive pulmonary disease co-exist in a significant proportion of patients. Whether asthma increases mortality risk among subjects with airflow limitation remains controversial. We used data from 2121 adult participants in the population-based Tucson Epidemiological Study of Airway Obstructive Disease cohort. At enrolment (1972–1973), participants completed questionnaires and lung function tests. Participants were categorised into four groups based on the combination of airflow limitation (AL; forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC)
Asthma, airflow limitation and mortality risk in the general population Shuang Huang1,2, Monica M. Vasquez1,2, Marilyn Halonen1, Fernando D. Martinez1 and Stefano Guerra1,3 Affiliations: 1Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA. 2Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA. 3CREAL Centre, CIBERESP, Universitat Pompeu Fabra, Barcelona, Spain. Correspondence: Stefano Guerra, Arizona Respiratory Center, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724-5030, USA. E-mail: [email protected]
ABSTRACT Asthma and chronic obstructive pulmonary disease co-exist in a significant proportion of patients. Whether asthma increases mortality risk among subjects with airflow limitation remains controversial. We used data from 2121 adult participants in the population-based Tucson Epidemiological Study of Airway Obstructive Disease cohort. At enrolment (1972–1973), participants completed questionnaires and lung function tests. Participants were categorised into four groups based on the combination of airflow limitation (AL; forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC)
