CLINICAL INVESTIGATIONS

Associations Between Serum 25-Hydroxyvitamin D Concentrations and Multiple Health Conditions, Physical Performance Measures, Disability, and All-Cause Mortality: The Concord Health and Ageing in Men Project Vasant Hirani, PhD,a,b Robert G. Cumming, PhD,a,b Vasi Naganathan, PhD,a Fiona Blyth, PhD,a David G. Le Couteur, PhD,a,c David J. Handelsman, PhD,d,e Louise M. Waite, PhD,a and Markus J. Seibel, PhDf,g

OBJECTIVES: To explore associations between serum 25-hydroxyvitamin D (25(OH)D) levels and a wide range of health conditions, physical performance measures, disability, and mortality in a large epidemiological study to identify an optimum range for 25(OH)D concentrations. DESIGN: Cross-sectional study, with additional prospective data on falls and mortality. SETTING: Concord Health and Ageing in Men Project, Sydney, Australia. PARTICIPANTS: Community-dwelling men aged 70 and older (N = 1,659). MEASUREMENTS: Serum 25(OH)D levels, general health status, self-reported diseases, physical performance measures, disability (activities of daily living and instrumental activities of daily living) and falls. RESULTS: Fair, poor, and very poor health; self-reported diabetes mellitus; hyperglycemia; depression; muscle weakness; poor balance; and all-cause mortality were all associated with serum 25(OH)D levels less than 50 nmol/L, even after adjustment for confounding. The findings also suggest that, in older men, for a wide range of health conditions, physical performance measures, disability, falls, and mortality, the optimum range of 25(OH)D is between 50.0 and 74.9 nmol/L, with no additional benefit for 25(OH)D levels of 75.0 nmol/L or greater.

From the aCentre for Education and Research on Ageing, Concord b Hospital, University of Sydney, School of Public Health, University of c Sydney, Charles Perkins Centre, University of Sydney, dDepartment of Andrology, Concord Hospital, University of Sydney, eANZAC Research Institute, University of Sydney, fDepartment of Endocrinology and Metabolism, Concord Hospital, University of Sydney, and gBone Research Program, University of Sydney, Sydney, New South Wales, Australia. Address correspondence to Dr. Vasant Hirani, Centre for Education and Research on Ageing, Concord Hospital, Hospital Road, Concord, NSW 2139, Australia. E-mail: [email protected] DOI: 10.1111/jgs.12693

JAGS 62:417–425, 2014 © 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society

CONCLUSION: Programs aimed at achieving an optimum range of serum 25(OH)D at levels between 50.0 and 74.9 nmol/L may have overall health benefits and such levels are adequate for older men. J Am Geriatr Soc 62:417–425, 2014.

Key words: vitamin D levels; older men; health outcomes; Sydney; Australia; population study

I

nadequate vitamin levels D (25-hydroxyvitamin D (25(OH)D) concentrations

Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: the Concord Health and Ageing in Men Project.

To explore associations between serum 25-hydroxyvitamin D (25(OH)D) levels and a wide range of health conditions, physical performance measures, disab...
128KB Sizes 0 Downloads 3 Views

Recommend Documents