European Heart Journal: Acute Cardiovascular Care http://acc.sagepub.com/
Association of upstream clopidogrel administration and myocardial reperfusion assessed by cardiac magnetic resonance imaging in patients with ST-elevation myocardial infarction Suzanne de Waha, Ingo Eitel, Steffen Desch, Georg Fuernau, Philipp Lurz, Gerhard Schuler and Holger Thiele European Heart Journal: Acute Cardiovascular Care 2014 3: 110 originally published online 10 February 2014 DOI: 10.1177/2048872614520752 The online version of this article can be found at: http://acc.sagepub.com/content/3/2/110
Published by: European Society of Cardiology
ESC Working Group on Acute Cardiac Care
and http://www.sagepublications.com
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ACC0010.1177/2048872614520752European Heart Journal: Acute Cardiovascular CareDe Mesh et al
EUROPEAN SOCIETY OF CARDIOLOGY ®
Original scientific paper
Association of upstream clopidogrel administration and myocardial reperfusion assessed by cardiac magnetic resonance imaging in patients with ST-elevation myocardial infarction
European Heart Journal: Acute Cardiovascular Care 2014, Vol. 3(2) 110–117 © The European Society of Cardiology 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/2048872614520752 acc.sagepub.com
Suzanne de Waha1, Ingo Eitel1, Steffen Desch1, Georg Fuernau1, Philipp Lurz1, Gerhard Schuler1 and Holger Thiele2
Abstract Background: Current ST-elevation myocardial infarction (STEMI) guidelines recommend initiation of clopidogrel treatment as early as possible before angiography, based on pharmacokinetic and positive registry data. However, the mechanisms of the beneficial effect of clopidogrel pretreatment are unclear. Aim of this study was to investigate the impact of upstream clopidogrel on infarct size and microvascular obstruction (MO) assessed by cardiac magnetic resonance imaging (CMR) in STEMI patients. Methods: STEMI patients reperfused by primary angioplasty (n=423)
Association of upstream clopidogrel administration and myocardial reperfusion assessed by cardiac magnetic resonance imaging in patients with ST-elevation myocardial infarction Suzanne de Waha, Ingo Eitel, Steffen Desch, Georg Fuernau, Philipp Lurz, Gerhard Schuler and Holger Thiele European Heart Journal: Acute Cardiovascular Care 2014 3: 110 originally published online 10 February 2014 DOI: 10.1177/2048872614520752 The online version of this article can be found at: http://acc.sagepub.com/content/3/2/110
Published by: European Society of Cardiology
ESC Working Group on Acute Cardiac Care
and http://www.sagepublications.com
Additional services and information for European Heart Journal: Acute Cardiovascular Care can be found at: Email Alerts: http://acc.sagepub.com/cgi/alerts Subscriptions: http://acc.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav
>> Version of Record - May 2, 2014 OnlineFirst Version of Record - Feb 10, 2014 What is This?
Downloaded from acc.sagepub.com at UNIVERSITE LAVAL on June 23, 2014
20752
014
ACC0010.1177/2048872614520752European Heart Journal: Acute Cardiovascular CareDe Mesh et al
EUROPEAN SOCIETY OF CARDIOLOGY ®
Original scientific paper
Association of upstream clopidogrel administration and myocardial reperfusion assessed by cardiac magnetic resonance imaging in patients with ST-elevation myocardial infarction
European Heart Journal: Acute Cardiovascular Care 2014, Vol. 3(2) 110–117 © The European Society of Cardiology 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/2048872614520752 acc.sagepub.com
Suzanne de Waha1, Ingo Eitel1, Steffen Desch1, Georg Fuernau1, Philipp Lurz1, Gerhard Schuler1 and Holger Thiele2
Abstract Background: Current ST-elevation myocardial infarction (STEMI) guidelines recommend initiation of clopidogrel treatment as early as possible before angiography, based on pharmacokinetic and positive registry data. However, the mechanisms of the beneficial effect of clopidogrel pretreatment are unclear. Aim of this study was to investigate the impact of upstream clopidogrel on infarct size and microvascular obstruction (MO) assessed by cardiac magnetic resonance imaging (CMR) in STEMI patients. Methods: STEMI patients reperfused by primary angioplasty (n=423)
