ENDOCRINE PRACTICE Rapid Electronic Article in Press Rapid Electronic Articles in Press are preprinted manuscripts that have been reviewed and accepted for publication, but have yet to be edited, typeset and finalized. This version of the manuscript will be replaced with the final, published version after it has been published in the print edition of the journal. The final, published version may differ from this proof. DOI:10.4158/EP14254.OR © 2014 AACE.

Original Article EP14254.OR ASSOCIATION OF SOLUBLE (PRO) RENIN RECEPTOR WITH GESTATIONAL DIABETES MELLITUS Kuppan Gokulakrishnan, PhD1;Kumar Maheswari M.Sc, M.Phil1; Manni Mohanraj Mahalakshmi, MPH1; Gunasekaran Kalaiyarasi, MPH1; Balaji Bhavadharini, MSc1; Gautam Kumar Pandey, MTech1; Jalaja Ramesh, MBBS, DNB, DCP2; Uma Ram, DGO,DNB, FRCOG3;Viswanathan Mohan, MD, FRCP, PhD1

Running title: Soluble (Pro)Renin Receptor in gestational diabetes From: 1Madras Diabetes Research Foundation & Dr. Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, 600086, India; 2St.Isabel’s Hospital, Chennai, India; 3 Seethapathy Clinic & Hospital, Chennai, India

Correspondence Address: Dr. V. MOHAN, M.D., FRCP (London, Edinburgh, Glasgow, Ireland), Ph.D., D.Sc. D.Sc (Hon. Causa), FNASc, FASc, FNA, FTWAS Director, Madras Diabetes Research Foundation & Chairman & Chief Diabetologist, Dr. Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for NonCommunicable Diseases Prevention and Control & IDF Centre For Education 4, Conran Smith Road, Gopalapuram, Chennai - 600 086, India Email: [email protected]

DOI:10.4158/EP14254.OR © 2014 AACE.

Key words: Soluble (Pro)Renin Receptor, gestational diabetes, Asian Indians, South Asians No. of Tables: 2, No. of Figures: 3 Word count: 2073

; Abstract: 250

No. of References: 34 ; Conflict of interest: Nil

Abstract Aim: There is a need to identify biomarkers for Gestational Diabetes Mellitus (GDM). Recently the soluble pro-renin receptor [s(Pro)RR] has been shown to be associated with GDM. We investigated the association of s(Pro)RR levels in Asian Indians with GDM .

Methods: We recruited 222 pregnant women, 147 without GDM (non-GDM) and 75 with GDM visiting antenatal clinics in Tamilnadu in south India. We included singleton pregnancy and excluded those with preexisting diabetes mellitus or hypertension. Oral glucose tolerance test (OGTT) was done and GDM was diagnosed using the International Association of Diabetes and Pregnancy Study Group criteria. s(Pro)RR


measured by enzyme-linked immunosorbent

assay. Receiver Operating Characteristic (ROC) curves were used to identify s(Pro)RR cut points to identify GDM.

Results: The mean levels of the s(Pro)RR were significantly higher in women with GDM [34.0 ± 12 ng/ml; p

Association of Soluble (Pro) Renin Receptor with Gestational Diabetes Mellitus.

There is a need to identify biomarkers for gestational diabetes mellitus (GDM). Recently the soluble pro-renin receptor (s[Pro]RR) has been shown to b...
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