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Mayo Clin Proc. Author manuscript; available in PMC 2017 February 01. Published in final edited form as: Mayo Clin Proc. 2016 February ; 91(2): 196–207. doi:10.1016/j.mayocp.2015.10.026.
Association of slopes of estimated GFR with post-ESRD mortality in advanced CKD patients transitioning to dialysis Keiichi Sumida, MD1, Miklos Z. Molnar, MD, PhD1, Praveen K. Potukuchi, MS1, Fridtjof Thomas, PhD1, Jun L. Lu, MD1, Jennie Jing, MS2, Vanessa A. Ravel, MPH2, Melissa Soohoo, MPH2, Connie M. Rhee, MD, MS2, Elani Streja, MPH, PhD2, Kamyar KalantarZadeh, MD, MPH, PhD2, and Csaba P. Kovesdy, MD1,3
Author Manuscript
1Division
of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States
2Harold
Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California-Irvine, Orange, CA, United States
3Nephrology
Section, Memphis VA Medical Center, Memphis, TN, United States
Abstract Objective—To investigate the association of estimated glomerular filtration rate (eGFR) slopes prior to dialysis initiation with cause-specific mortality following dialysis initiation.
Author Manuscript
Patients and Methods—In this retrospective cohort study of 18,874 United States veterans who had transitioned to dialysis from October 1, 2007, through September 30, 2011, we examined the association of pre-end-stage renal disease (ESRD) eGFR slopes with all-cause, cardiovascular, and infection-related mortality during the post-ESRD period over a median follow-up of 2.0 years (interquartile range; 1.1–3.2 years). Associations were examined using Cox models with adjustment for potential confounders.
Author Manuscript
Results—Prior to transitioning to dialysis, 4,485 (23.8%), 5,633 (29.8%), and 7,942 (42.1%) patients experienced fast, moderate, and slow eGFR decline, respectively, and 814 (4.3%) had increasing eGFR (defined as eGFR slopes of
Mayo Clin Proc. Author manuscript; available in PMC 2017 February 01. Published in final edited form as: Mayo Clin Proc. 2016 February ; 91(2): 196–207. doi:10.1016/j.mayocp.2015.10.026.
Association of slopes of estimated GFR with post-ESRD mortality in advanced CKD patients transitioning to dialysis Keiichi Sumida, MD1, Miklos Z. Molnar, MD, PhD1, Praveen K. Potukuchi, MS1, Fridtjof Thomas, PhD1, Jun L. Lu, MD1, Jennie Jing, MS2, Vanessa A. Ravel, MPH2, Melissa Soohoo, MPH2, Connie M. Rhee, MD, MS2, Elani Streja, MPH, PhD2, Kamyar KalantarZadeh, MD, MPH, PhD2, and Csaba P. Kovesdy, MD1,3
Author Manuscript
1Division
of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States
2Harold
Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California-Irvine, Orange, CA, United States
3Nephrology
Section, Memphis VA Medical Center, Memphis, TN, United States
Abstract Objective—To investigate the association of estimated glomerular filtration rate (eGFR) slopes prior to dialysis initiation with cause-specific mortality following dialysis initiation.
Author Manuscript
Patients and Methods—In this retrospective cohort study of 18,874 United States veterans who had transitioned to dialysis from October 1, 2007, through September 30, 2011, we examined the association of pre-end-stage renal disease (ESRD) eGFR slopes with all-cause, cardiovascular, and infection-related mortality during the post-ESRD period over a median follow-up of 2.0 years (interquartile range; 1.1–3.2 years). Associations were examined using Cox models with adjustment for potential confounders.
Author Manuscript
Results—Prior to transitioning to dialysis, 4,485 (23.8%), 5,633 (29.8%), and 7,942 (42.1%) patients experienced fast, moderate, and slow eGFR decline, respectively, and 814 (4.3%) had increasing eGFR (defined as eGFR slopes of
