Original Article
Endocrinol Metab 2017;32:230-240 https://doi.org/10.3803/EnM.2017.32.2.230 pISSN 2093-596X · eISSN 2093-5978
Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects Ali Ahmed Al Qarni1,*, Faris Elbahi Joatar1,*, Nagalla Das2, Mohamed Awad3, Mona Eltayeb3, Ahmed Gasim Al-Zubair1, Muhalab E. Ali4, Abdulaziz Al Masaud1, Abdirashid M. Shire1, Khalid Gumaa4, Hayder A. Giha4 Department of Internal Medicine and Clinical Biochemistry Laboratory, King Abdulaziz Hospital, National Guard Health Affairs, Al-Ahsa, Saudi Arabia; 2Clinical Biochemistry Laboratory, Salmaniya Medical Complex, Manama, Bahrain; 3Primary Health Centre, National Guard Health Affairs, Al-Ahsa, Saudi Arabia; 4Department of Medical Biochemistry, Arabian Gulf University College of Medicine and Medical Sciences, Manama, Bahrain 1
Background: Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The aim of this study was to examine the relationship between plasma ghrelin levels and IR in Saudi subjects with T2DM. Methods: Patients with T2DM (n=107, cases) and non-diabetic apparently healthy subjects (n=101, controls) from Saudi Arabia were included in this study. The biochemical profiles and plasma insulin levels of all subjects were analyzed, and IR was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR) index. Active ghrelin levels in plasma were measured using the radioimmunoassay technique. Results: Only 46.7% (50 of 107) of the T2DM subjects had IR, including 26% (28 of 107) with severe IR (HOMA-IR ≥5), while 5.9% (six of 101) of the controls had moderate IR (3≤ HOMA-IR
Endocrinol Metab 2017;32:230-240 https://doi.org/10.3803/EnM.2017.32.2.230 pISSN 2093-596X · eISSN 2093-5978
Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects Ali Ahmed Al Qarni1,*, Faris Elbahi Joatar1,*, Nagalla Das2, Mohamed Awad3, Mona Eltayeb3, Ahmed Gasim Al-Zubair1, Muhalab E. Ali4, Abdulaziz Al Masaud1, Abdirashid M. Shire1, Khalid Gumaa4, Hayder A. Giha4 Department of Internal Medicine and Clinical Biochemistry Laboratory, King Abdulaziz Hospital, National Guard Health Affairs, Al-Ahsa, Saudi Arabia; 2Clinical Biochemistry Laboratory, Salmaniya Medical Complex, Manama, Bahrain; 3Primary Health Centre, National Guard Health Affairs, Al-Ahsa, Saudi Arabia; 4Department of Medical Biochemistry, Arabian Gulf University College of Medicine and Medical Sciences, Manama, Bahrain 1
Background: Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The aim of this study was to examine the relationship between plasma ghrelin levels and IR in Saudi subjects with T2DM. Methods: Patients with T2DM (n=107, cases) and non-diabetic apparently healthy subjects (n=101, controls) from Saudi Arabia were included in this study. The biochemical profiles and plasma insulin levels of all subjects were analyzed, and IR was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR) index. Active ghrelin levels in plasma were measured using the radioimmunoassay technique. Results: Only 46.7% (50 of 107) of the T2DM subjects had IR, including 26% (28 of 107) with severe IR (HOMA-IR ≥5), while 5.9% (six of 101) of the controls had moderate IR (3≤ HOMA-IR
