Association of Interleukin-6 With the Progression of Carotid Atherosclerosis A 9-Year Follow-Up Study Shuhei Okazaki, MD; Manabu Sakaguchi, MD; Kaori Miwa, MD; Shigetaka Furukado, MD; Hiroshi Yamagami, MD; Yoshiki Yagita, MD; Hideki Mochizuki, MD; Kazuo Kitagawa, MD Background and Purpose—Limited information is available on the long-term effects of interleukin-6 (IL-6) on systemic atherosclerosis. The purpose of the present study was to clarify the relationship between chronic elevation of IL-6 and the long-term progression of carotid atherosclerosis. Methods—We prospectively evaluated 210 patients with ≥1 vascular risk factors for 9.0±1.0 years. Carotid mean-maximal intima-media thickness (mmIMT), the serum high-sensitivity C-reactive protein (hs-CRP) level, and the serum IL-6 level were measured at baseline and every 3 years. The associations between the progression of mmIMT and the long-term average levels of hs-CRP and IL-6 were analyzed. Results—Carotid mmIMT increased throughout the study period (0.031±0.026 mm/y). Baseline mmIMT was significantly associated with baseline hs-CRP (P=0.002) and baseline IL-6 (P80% of the participants underwent carotid ultrasonography measurements every 3 years, and we verified the linear progression of the average mmIMT throughout the study period. In conclusion, the results of the present study indicate that chronic elevation of the serum IL-6 level is associated with the progression of atherosclerosis in patients with vascular risk factors. These findings warrant further investigation of IL-6 as a quantitative maker and a potential therapeutic target for accelerated atherosclerosis.

Acknowledgments We thank C. Ito and K. Nishiyama for their secretarial assistance.

Sources of Funding This work was supported by Japan Society for the Promotion of Science KAKENHI Grant No. 24790882 and in part by the Ministry of Health, Labour, and Welfare of Japan (H14-023, H15-020, H16003, H17-001, and H22-006).

Disclosures None.

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Association of Interleukin-6 With the Progression of Carotid Atherosclerosis: A 9-Year Follow-Up Study Shuhei Okazaki, Manabu Sakaguchi, Kaori Miwa, Shigetaka Furukado, Hiroshi Yamagami, Yoshiki Yagita, Hideki Mochizuki and Kazuo Kitagawa Stroke. 2014;45:2924-2929; originally published online August 19, 2014; doi: 10.1161/STROKEAHA.114.005991 Stroke is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Copyright © 2014 American Heart Association, Inc. All rights reserved. Print ISSN: 0039-2499. Online ISSN: 1524-4628

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Association of interleukin-6 with the progression of carotid atherosclerosis: a 9-year follow-up study.

Limited information is available on the long-term effects of interleukin-6 (IL-6) on systemic atherosclerosis. The purpose of the present study was to...
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