www.nature.com/scientificreports
OPEN
received: 10 March 2016 accepted: 26 May 2016 Published: 16 June 2016
Association of Increased Serum Leptin with Ameliorated Anemia and Malnutrition in Stage 5 Chronic Kidney Disease Patients after Parathyroidectomy Yao Jiang1,*, Jingjing Zhang1,*, Yanggang Yuan1, Xiaoming Zha2, Changying Xing1, Chong Shen3, Zhixiang Shen4, Chao Qin5, Ming Zeng1, Guang Yang1, Huijuan Mao1, Bo Zhang1, Xiangbao Yu1, Bin Sun1, Chun Ouyang1, Xueqiang Xu1, Yifei Ge1, Jing Wang1, Lina Zhang1, Chen Cheng1, Caixia Yin1, Jing Zhang1, Huimin Chen1, Haoyang Ma1 & Ningning Wang1 Leptin is an adipokine that regulates various metabolism, but its association with secondary hyperparathyroidism (SHPT), a clinical manifestation of chronic kidney disease-mineral and bone disorder (CKD-MBD), remains obscure. Parathyroidectomy (PTX) is recommended for severe SHPT patients. Here, the associations between circulating leptin and clinical characteristics in CKD patients were investigated. Effects of PTX on leptin production were analyzed in vivo and in vitro. Controls and CKD patients had approximate serum leptin levels in that a larger proportion of CKD patients with body mass index (BMI)
OPEN
received: 10 March 2016 accepted: 26 May 2016 Published: 16 June 2016
Association of Increased Serum Leptin with Ameliorated Anemia and Malnutrition in Stage 5 Chronic Kidney Disease Patients after Parathyroidectomy Yao Jiang1,*, Jingjing Zhang1,*, Yanggang Yuan1, Xiaoming Zha2, Changying Xing1, Chong Shen3, Zhixiang Shen4, Chao Qin5, Ming Zeng1, Guang Yang1, Huijuan Mao1, Bo Zhang1, Xiangbao Yu1, Bin Sun1, Chun Ouyang1, Xueqiang Xu1, Yifei Ge1, Jing Wang1, Lina Zhang1, Chen Cheng1, Caixia Yin1, Jing Zhang1, Huimin Chen1, Haoyang Ma1 & Ningning Wang1 Leptin is an adipokine that regulates various metabolism, but its association with secondary hyperparathyroidism (SHPT), a clinical manifestation of chronic kidney disease-mineral and bone disorder (CKD-MBD), remains obscure. Parathyroidectomy (PTX) is recommended for severe SHPT patients. Here, the associations between circulating leptin and clinical characteristics in CKD patients were investigated. Effects of PTX on leptin production were analyzed in vivo and in vitro. Controls and CKD patients had approximate serum leptin levels in that a larger proportion of CKD patients with body mass index (BMI)
