BIOMEDICAL REPORTS 4: 178-182, 2016
178
Association of genetic variants with atrial fibrillation YUICHIRO YAMASE1, KIMIHIKO KATO2, HIDEKI HORIBE1, CHIKARA UEYAMA1, TETSUO FUJIMAKI3, MITSUTOSHI OGURI4, MASAZUMI ARAI5, SACHIRO WATANABE5, TOYOAKI MUROHARA6 and YOSHIJI YAMADA7 1
Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu 507-8522; Department of Internal Medicine, Meitoh Hospital, Nagoya, Aichi 465-0025; 3Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Mie 511-0428; 4Department of Cardiology, Kasugai Municipal Hospital, Kasugai, Aichi 486-8510; 5 Department of Cardiology, Gifu Prefectural General Medical Center, Gifu, Gifu 500-8717; 6Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550; 7Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514-8507, Japan 2
Received October 1, 2015; Accepted November 27, 2015 DOI: 10.3892/br.2015.551 Abstract. Recent genome-wide association studies (GWASs) identified various genes and loci that confer susceptibility to coronary artery disease or myocardial infarction among Caucasian populations. As myocardial ischemia is an important risk factor for atrial fibrillation, we hypothesized that certain polymorphisms may contribute to the genetic susceptibility to atrial fibrillation through affecting the susceptibility to coronary artery disease. The aim of the present study was to examine the possible association of atrial fibrillation in Japanese individuals with 29 polymorphisms identified as susceptibility loci for coronary artery disease or myocardial infarction in the meta‑analyses of GWASs in Caucasian populations. The study subjects comprised 5,470 Japanese individuals (305 subjects with atrial fibrillation and 5,165 controls). Genotypes for 29 polymorphisms were determined by a method that combines the polymerase chain reaction and sequence‑specific oligonucleotide probes with suspension array technology. Comparisons of the allele frequencies by the χ2 test revealed that rs599839 (G→A) of the proline/serine‑rich coiled‑coil 1 gene (PSRC1, P=0.0084) and rs11556924 (C→T, Arg363His) of the zinc finger, C3HC‑type containing 1 gene (ZC3HC1, P=0.0076) were significantly (P
178
Association of genetic variants with atrial fibrillation YUICHIRO YAMASE1, KIMIHIKO KATO2, HIDEKI HORIBE1, CHIKARA UEYAMA1, TETSUO FUJIMAKI3, MITSUTOSHI OGURI4, MASAZUMI ARAI5, SACHIRO WATANABE5, TOYOAKI MUROHARA6 and YOSHIJI YAMADA7 1
Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu 507-8522; Department of Internal Medicine, Meitoh Hospital, Nagoya, Aichi 465-0025; 3Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Mie 511-0428; 4Department of Cardiology, Kasugai Municipal Hospital, Kasugai, Aichi 486-8510; 5 Department of Cardiology, Gifu Prefectural General Medical Center, Gifu, Gifu 500-8717; 6Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550; 7Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514-8507, Japan 2
Received October 1, 2015; Accepted November 27, 2015 DOI: 10.3892/br.2015.551 Abstract. Recent genome-wide association studies (GWASs) identified various genes and loci that confer susceptibility to coronary artery disease or myocardial infarction among Caucasian populations. As myocardial ischemia is an important risk factor for atrial fibrillation, we hypothesized that certain polymorphisms may contribute to the genetic susceptibility to atrial fibrillation through affecting the susceptibility to coronary artery disease. The aim of the present study was to examine the possible association of atrial fibrillation in Japanese individuals with 29 polymorphisms identified as susceptibility loci for coronary artery disease or myocardial infarction in the meta‑analyses of GWASs in Caucasian populations. The study subjects comprised 5,470 Japanese individuals (305 subjects with atrial fibrillation and 5,165 controls). Genotypes for 29 polymorphisms were determined by a method that combines the polymerase chain reaction and sequence‑specific oligonucleotide probes with suspension array technology. Comparisons of the allele frequencies by the χ2 test revealed that rs599839 (G→A) of the proline/serine‑rich coiled‑coil 1 gene (PSRC1, P=0.0084) and rs11556924 (C→T, Arg363His) of the zinc finger, C3HC‑type containing 1 gene (ZC3HC1, P=0.0076) were significantly (P
