Tumor Biol. (2014) 35:3363–3376 DOI 10.1007/s13277-013-1443-2
RESEARCH ARTICLE
Association between the CYP1A1 A2455G polymorphism and risk of cancer: evidence from 272 case–control studies Jun Qin & Jin-Xia Zhang & Xiao-Ping Li & Bu-Qiang Wu & Guang-Bin Chen & Xiao-Feng He
Received: 20 June 2013 / Accepted: 18 November 2013 / Published online: 5 December 2013 # International Society of Oncology and BioMarkers (ISOBM) 2013
Abstract A2455G is a common polymorphism in CYP1A1, showing differences in its biological functions. Case–control studies have been performed to elucidate the role of A2455G in cancer; however, the results are conflicting and heterogeneous. Hence, we performed a meta-analysis to investigate the association between cancer susceptibility and A2455G (64,593 cases and 91,056 controls from 272 studies) polymorphism in different inheritance models. We used odds ratios with 95 % confidence intervals to assess the strength of the association. Overall, significantly increased cancer risk was observed in any genetic model (dominant model, odds ration [OR]=1.19, 95 % confidence interval [CI]=1.13–1.25; recessive model: OR=1.41, 95 % CI=1.29–1.54; additive model: OR=1.49, 95 % CI=1.35–1.65) when all eligible studies were pooled into the meta-analysis. In further stratified and sensitivity analyses, the elevated risk remained for subgroups of Electronic supplementary material The online version of this article (doi:10.1007/s13277-013-1443-2) contains supplementary material, which is available to authorized users. J. Qin : B.
RESEARCH ARTICLE
Association between the CYP1A1 A2455G polymorphism and risk of cancer: evidence from 272 case–control studies Jun Qin & Jin-Xia Zhang & Xiao-Ping Li & Bu-Qiang Wu & Guang-Bin Chen & Xiao-Feng He
Received: 20 June 2013 / Accepted: 18 November 2013 / Published online: 5 December 2013 # International Society of Oncology and BioMarkers (ISOBM) 2013
Abstract A2455G is a common polymorphism in CYP1A1, showing differences in its biological functions. Case–control studies have been performed to elucidate the role of A2455G in cancer; however, the results are conflicting and heterogeneous. Hence, we performed a meta-analysis to investigate the association between cancer susceptibility and A2455G (64,593 cases and 91,056 controls from 272 studies) polymorphism in different inheritance models. We used odds ratios with 95 % confidence intervals to assess the strength of the association. Overall, significantly increased cancer risk was observed in any genetic model (dominant model, odds ration [OR]=1.19, 95 % confidence interval [CI]=1.13–1.25; recessive model: OR=1.41, 95 % CI=1.29–1.54; additive model: OR=1.49, 95 % CI=1.35–1.65) when all eligible studies were pooled into the meta-analysis. In further stratified and sensitivity analyses, the elevated risk remained for subgroups of Electronic supplementary material The online version of this article (doi:10.1007/s13277-013-1443-2) contains supplementary material, which is available to authorized users. J. Qin : B.
