RESEARCH ARTICLE

Association between Self-Reported Smoking and Hemoglobin A1c in a Korean Population without Diabetes: The 2011–2012 Korean National Health and Nutrition Examination Survey a11111

Jae Won Hong1, Cheol Ryong Ku2, Jung Hyun Noh1, Kyung Soo Ko3, Byoung Doo Rhee3, Dong-Jun Kim1* 1 Department of Internal Medicine, Ilsan-Paik Hospital, College of Medicine, Inje University, Koyang, Gyeonggi-do, South Korea, 2 Endocrinology, Yonsei University College of Medicine, Seoul, South Korea, 3 Department of Internal Medicine, Sanggye Paik Hospital, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Seoul, Republic of Korea * [email protected]

OPEN ACCESS Citation: Hong JW, Ku CR, Noh JH, Ko KS, Rhee BD, Kim D-J (2015) Association between SelfReported Smoking and Hemoglobin A1c in a Korean Population without Diabetes: The 2011–2012 Korean National Health and Nutrition Examination Survey. PLoS ONE 10(5): e0126746. doi:10.1371/journal. pone.0126746 Academic Editor: Barbara Fuhrman, University of Arkansas for Medical Sciences, UNITED STATES Received: May 7, 2014 Accepted: April 7, 2015 Published: May 26, 2015 Copyright: © 2015 Hong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: The raw data are owned by Korea Centers for Disease Control and Preservation. Anybody who signs up for membership can get raw data from the webpage of Korea Centers for Disease Control & Preservation(https://knhanes. cdc.go.kr/knhanes/index.do). Funding: The authors have no support or funding to report. Competing Interests: The authors have declared that no competing interests exist.

Abstract Background Several Western studies have revealed that among non-diabetics, glycosylated hemoglobin A1c (HbA1c) levels are higher in smokers than non-smokers. While studies conducted in Western populations consistently support this association, a recent meta-analysis reported that studies carried out in non-Western populations, including studies of Chinese, Egyptian, and Japanese-Americans, did not detect any significant differences in HbA1c levels between smokers and non-smokers.

Objectives We assessed the association between smoking habits and HbA1c levels in the general Korean adult population using data from the Korean National Health and Nutrition Examination Survey (KNHANES) performed in 2011–2012.

Methods A total of 10,241 participants (weighted n=33,946,561 including 16,769,320 men and 17,177,241 women) without diabetes were divided into four categories according to their smoking habits: never smokers (unweighted n/ weighted n= 6,349/19,105,564), ex-smokers (unweighted n/ weighted n= 1,912/6,207,144), current light smokers (

Association between Self-Reported Smoking and Hemoglobin A1c in a Korean Population without Diabetes: The 2011-2012 Korean National Health and Nutrition Examination Survey.

Several Western studies have revealed that among non-diabetics, glycosylated hemoglobin A1c (HbA1c) levels are higher in smokers than non-smokers. Whi...
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