Int J Clin Exp Pathol 2015;8(7):8463-8471 www.ijcep.com /ISSN:1936-2625/IJCEP0009995
Original Article Association between promoter region genetic variants of PTH SNPs and serum 25(OH)-vitamin D level Nasser M Al-Daghri1,2, Omar S Al-Attas1,2, Soundararajan Krishnaswamy1, Sobhy M Yakout1, Abdul Khader Mohammed1, Amal M Alenad3, George P Chrousos4, Majed S Alokail1,2 Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA; Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA; 3School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK; 4First Department of Pediatrics, Athens University Medical School, Athens, Greece 1 2
Received May 7, 2014; Accepted June 23, 2015; Epub July 1, 2015; Published July 15, 2015 Abstract: Parathyroid hormone (PTH) plays a crucial role in calcium metabolism and skeletal development via altering vitamin D level. Besides, hypersecretion of PTH is implicated in the etiology of osteoporosis. In this study, we analyzed association between promoter region sequence variants of PTH gene and circulating 25-hydroxy-vitamin D (25(OH)D) level. Genotypes of PTH SNPs rs1459015, rs10500783 and rs10500784 and circulating serum 25(OH) D level of healthy adults (N=386) of different nationalities living in Riyadh were determined and relation between the different PTH allelic variants and corresponding mean 25(OH)D values were obtained using Analysis of Variance (ANOVA) and Bonferroni post-hoc test for multiple comparisons. We observed a high prevalence of vitamin D deficiency (
Original Article Association between promoter region genetic variants of PTH SNPs and serum 25(OH)-vitamin D level Nasser M Al-Daghri1,2, Omar S Al-Attas1,2, Soundararajan Krishnaswamy1, Sobhy M Yakout1, Abdul Khader Mohammed1, Amal M Alenad3, George P Chrousos4, Majed S Alokail1,2 Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA; Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA; 3School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK; 4First Department of Pediatrics, Athens University Medical School, Athens, Greece 1 2
Received May 7, 2014; Accepted June 23, 2015; Epub July 1, 2015; Published July 15, 2015 Abstract: Parathyroid hormone (PTH) plays a crucial role in calcium metabolism and skeletal development via altering vitamin D level. Besides, hypersecretion of PTH is implicated in the etiology of osteoporosis. In this study, we analyzed association between promoter region sequence variants of PTH gene and circulating 25-hydroxy-vitamin D (25(OH)D) level. Genotypes of PTH SNPs rs1459015, rs10500783 and rs10500784 and circulating serum 25(OH) D level of healthy adults (N=386) of different nationalities living in Riyadh were determined and relation between the different PTH allelic variants and corresponding mean 25(OH)D values were obtained using Analysis of Variance (ANOVA) and Bonferroni post-hoc test for multiple comparisons. We observed a high prevalence of vitamin D deficiency (
