European Journal of Neurology 2014, 21: 1198–1204
doi:10.1111/ene.12468
Association between migraine and irritable bowel syndrome: a population-based retrospective cohort study C.-I. Laua,b, C.-C. Linc, W.-H. Chena,d, H.-C. Wanga,d,e and C.-H. Kaof,g a
Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; bDivision of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; cManagement Office for Health Data, China Medical University Hospital, Taichung; dCollege of Medicine, Taipei Medical University, Taipei; eCollege of Medicine, National Taiwan University, Taipei; fGraduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung; and gDepartment of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
Keywords:
irritable bowel syndrome, migraine, National Health Insurance Research Database, retrospective cohort study Received 24 December 2013 Accepted 8 April 2014
Background and purpose: Migraine and irritable bowel syndrome (IBS) share many similarities characterized by their epidemiology, periodic pain, lack of definable organic causes, trigger factors, comorbidities and proposed pathophysiology. In this retrospective case–control study, the association between migraine and IBS was investigated using a nationwide population-based database in Taiwan. Methods: The data were retrieved from the National Health Insurance Research Database (NHIRD) of Taiwan. In all, 14 117 newly diagnosed migraine cases were identified in a subset of the NHIRD and 56 468 migraine-free individuals were randomly selected as the comparison cohort. The multivariate Cox proportional hazards regression model was used to explore the risk of IBS in migraine sufferers after adjusting for demographic characteristics and comorbidities. Results: After adjusting for the covariates, the incidence of IBS was 1.95-fold higher in the migraine cohort than in the comparison cohort (73.87 vs. 30.14 per 10 000 person-years). The adjusted cumulative incidence of IBS was also higher in the migraine group than in the control group in the follow-up years (log-rank test, P < 0.0001). In addition, the risk was most prominent in the youngest group (
doi:10.1111/ene.12468
Association between migraine and irritable bowel syndrome: a population-based retrospective cohort study C.-I. Laua,b, C.-C. Linc, W.-H. Chena,d, H.-C. Wanga,d,e and C.-H. Kaof,g a
Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; bDivision of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; cManagement Office for Health Data, China Medical University Hospital, Taichung; dCollege of Medicine, Taipei Medical University, Taipei; eCollege of Medicine, National Taiwan University, Taipei; fGraduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung; and gDepartment of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
Keywords:
irritable bowel syndrome, migraine, National Health Insurance Research Database, retrospective cohort study Received 24 December 2013 Accepted 8 April 2014
Background and purpose: Migraine and irritable bowel syndrome (IBS) share many similarities characterized by their epidemiology, periodic pain, lack of definable organic causes, trigger factors, comorbidities and proposed pathophysiology. In this retrospective case–control study, the association between migraine and IBS was investigated using a nationwide population-based database in Taiwan. Methods: The data were retrieved from the National Health Insurance Research Database (NHIRD) of Taiwan. In all, 14 117 newly diagnosed migraine cases were identified in a subset of the NHIRD and 56 468 migraine-free individuals were randomly selected as the comparison cohort. The multivariate Cox proportional hazards regression model was used to explore the risk of IBS in migraine sufferers after adjusting for demographic characteristics and comorbidities. Results: After adjusting for the covariates, the incidence of IBS was 1.95-fold higher in the migraine cohort than in the comparison cohort (73.87 vs. 30.14 per 10 000 person-years). The adjusted cumulative incidence of IBS was also higher in the migraine group than in the control group in the follow-up years (log-rank test, P < 0.0001). In addition, the risk was most prominent in the youngest group (
