Int J Clin Exp Pathol 2015;8(8):9567-9573 www.ijcep.com /ISSN:1936-2625/IJCEP0009880

Original Article Association between interluekin-17 gene polymorphisms and the risk of cervical cancer in a Chinese population Jianglin Cong1,2, Riming Liu3, Xuan Wang2, Li Sheng3, Haiyang Jiang2, Weihua Wang3, Youzhong Zhang1, Shujuan Yang4, Chaoying Li4 Department of Gynaecology, Qilu Hospital, Shandong University, China; Departments of 2Gynaecology, 3Laboratory, Qingdao University Affiliated Yantai Yuhuangding Hospital, China; 4Department of Health and Social Behavior, West China School of Public Health, Sichuan University, China 1

Received May 4, 2015; Accepted June 23, 2015; Epub August 1, 2015; Published August 15, 2015 Abstract: We conducted a study to analyze the association of three common SNPs of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 gene polymorphisms with the risk of cervical cancer in a Chinese population. Our study included 352 cervical cancer patients and 352 controls between January 2013 and December 2014. Genotyping of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 genes was performed by multiplex PCR assays using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). By χ2 test, there was significantly difference in the genotype distribution of IL-17A rs2275913 between cervical cancer patients and control subjects (χ2=11.45, P=0.003). By conditional logistic regression analysis, we found that individuals with the GA and AA genotypes were associated with an increased risk of cervical cancer when compared with the GG genotype in codominant model, and the adjusted Ors (95% CI) were 1.57 (1.13-2.18) and 2.01 (1.15-3.49), respectively. In dominant model, we found that the GA+AA genotype of rs2275913 was correlated with a moderate increased risk of cervical cancer compared with the GG genotype (OR=1.64, 95% CI=1.20-2.24). We only found significant interaction between rs2275913 polymorphism and HPV-16 or 18 infection in the risk of cervical cancer (P for interaction

Association between interluekin-17 gene polymorphisms and the risk of cervical cancer in a Chinese population.

We conducted a study to analyze the association of three common SNPs of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 gene polymorphisms with the...
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