RESEARCH ARTICLE

Association between Birth Interval and Cardiovascular Outcomes at 30 Years of Age: A Prospective Cohort Study from Brazil D. Devakumar1*, P. C. Hallal2, B. L. Horta2, F. C. Barros2, J. C. K. Wells3 1 Institute for Global Health, University College London, London, United Kingdom, 2 Federal University of Pelotas, Post-Graduate Programme in Epidemiology, Pelotas, Brazil, 3 Institute of Child Health, University College London, London, United Kingdom * [email protected]

Abstract OPEN ACCESS Citation: Devakumar D, Hallal PC, Horta BL, Barros FC, Wells JCK (2016) Association between Birth Interval and Cardiovascular Outcomes at 30 Years of Age: A Prospective Cohort Study from Brazil. PLoS ONE 11(2): e0149054. doi:10.1371/journal. pone.0149054 Editor: Odir Antônio Dellagostin, Federal University of Pelotas, BRAZIL Received: October 17, 2015 Accepted: January 25, 2016

Background Birth interval is an important and potentially modifiable factor that is associated with child health. Whether an association exists with longer-term outcomes in adults is less well known.

Methods Using the 1982 Pelotas (Brazil) Birth Cohort Study, the association of birth interval with markers of cardiovascular health at 30 years of age was examined. Multivariable linear regression was used with birth interval as a continuous variable and categorical variable, and effect modification by gender was explored.

Published: February 18, 2016 Copyright: © 2016 Devakumar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the Supporting Information files. Funding: The authors received no specific funding for this work. The cohort study was funded by the Wellcome Trust; the International Development Research Center (Canada); the Brazilian National Research Council (CNPq); Rio Grande do Sul State Research Support Foundation (FAPERGS); and the Brazilian Ministry of Health. The study is based on data from the study "Pelotas Birth Cohort, 1982" done by the Postgraduate Program in Epidemiology at Universidade Federal de Pelotas, with the

Results Birth interval and cardiovascular data were present for 2,239 individuals. With birth interval as a continuous variable, no association was found but stratification by gender tended to show stronger associations for girls. When compared to birth intervals of

Association between Birth Interval and Cardiovascular Outcomes at 30 Years of Age: A Prospective Cohort Study from Brazil.

Birth interval is an important and potentially modifiable factor that is associated with child health. Whether an association exists with longer-term ...
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