Assessment of Regional Gray Matter Loss in Dementia with Lewy Bodies: A Surface-Based MRI Analysis Rosie Watson, Ph.D., Sean J. Colloby, Ph.D., Andrew M. Blamire, Ph.D., John T. O’Brien, D.M.
Objective: To compare magnetic resonance imaging (MRI) patterns of cortical thinning in subjects with dementia with Lewy bodies (DLB), Alzheimer’s disease (AD), and normal aging and investigate the relationship between cortical thickness and clinical measures. Methods: Study participants (31 DLB, 30 AD, and 33 healthy comparison subjects) underwent 3-Tesla T1-weighted MRI and completed clinical and cognitive assessments. We used the FreeSurfer analysis package to measure cortical thickness and investigated the patterns of cortical thinning across groups. Results: Cortical thinning in AD was found predominantly in the temporal and parietal areas extending into the frontal lobes (N ¼ 63, df ¼ 59, t >3.3, p 3.6, p 2.8, p AD (U63 ¼ 47.9, p < 0.001), HS > DLB (U64 ¼ 42.6, p < 0.001), AD versus DLB (U61 ¼ 5.3, p ¼ 1.0). b HS > AD (U63 ¼ 50.0, p < 0.001), HS > DLB (U64 ¼ 43.0, p < 0.001), AD versus DLB (U61 ¼ 4.9, p ¼ 1.0). c HS > AD (U63 ¼ 17.0, p ¼ 0.04), HS > DLB (U64 ¼ 54.1, p < 0.001), AD versus DLB (U61 ¼ 37.1, p < 0.001).
similar. There were more men in the DLB group and, as expected, the DLB group had significantly higher UPDRS III scores than the AD and healthy comparison group. Comparison of AD and Healthy Subjects The areas of cortical thinning in AD compared with healthy older individuals are represented in Figure 1A, (N ¼ 63, df ¼ 59, t >3.3, p 3.6, p 4.1, p 2.8, p 2.8, p
Objective: To compare magnetic resonance imaging (MRI) patterns of cortical thinning in subjects with dementia with Lewy bodies (DLB), Alzheimer’s disease (AD), and normal aging and investigate the relationship between cortical thickness and clinical measures. Methods: Study participants (31 DLB, 30 AD, and 33 healthy comparison subjects) underwent 3-Tesla T1-weighted MRI and completed clinical and cognitive assessments. We used the FreeSurfer analysis package to measure cortical thickness and investigated the patterns of cortical thinning across groups. Results: Cortical thinning in AD was found predominantly in the temporal and parietal areas extending into the frontal lobes (N ¼ 63, df ¼ 59, t >3.3, p 3.6, p 2.8, p AD (U63 ¼ 47.9, p < 0.001), HS > DLB (U64 ¼ 42.6, p < 0.001), AD versus DLB (U61 ¼ 5.3, p ¼ 1.0). b HS > AD (U63 ¼ 50.0, p < 0.001), HS > DLB (U64 ¼ 43.0, p < 0.001), AD versus DLB (U61 ¼ 4.9, p ¼ 1.0). c HS > AD (U63 ¼ 17.0, p ¼ 0.04), HS > DLB (U64 ¼ 54.1, p < 0.001), AD versus DLB (U61 ¼ 37.1, p < 0.001).
similar. There were more men in the DLB group and, as expected, the DLB group had significantly higher UPDRS III scores than the AD and healthy comparison group. Comparison of AD and Healthy Subjects The areas of cortical thinning in AD compared with healthy older individuals are represented in Figure 1A, (N ¼ 63, df ¼ 59, t >3.3, p 3.6, p 4.1, p 2.8, p 2.8, p
