Radiol med (2015) 120:714–722 DOI 10.1007/s11547-015-0497-1
CARDIAC RADIOLOGY
Assessment of atrial diastolic function in patients with hypertrophic cardiomyopathy by cine magnetic resonance imaging Emanuele Grassedonio · Giancarlo Todiere · Ludovico La Grutta · Patrizia Toia · Giovanni D. Gentile · Massimo Galia · Federico Midiri · Alessia Pepe · Massimo Midiri · Giovanni Donato Aquaro
Received: 10 June 2014 / Accepted: 18 November 2014 / Published online: 10 February 2015 © Italian Society of Medical Radiology 2015
Abstract Purpose This study was conducted to assess the role of atrial function by cardiac magnetic resonance (CMR) for the evaluation of diastolic physiology in patients with hypertrophic cardiomyopathy (HCM) compared to healthy controls. Materials and methods We enrolled 23 consecutive patients affected by HCM and 43 healthy subjects as agematched control cases (CC). CMR was performed through acquisition of cine steady-state free precession sequences using a 1.5-T scanner. Image postprocessing was carried out using Tracking Tool software. Results Atrial volumes were significantly higher in patients with HCM compared to CC: maximum atrial volume (p = 0.007) and minimum atrial volume (p = 0.01). A statistically significant difference was also observed in atrial ejection fraction in patients with HCM (p 0.05
E/A
2.49 ± 1.9
PFRE/EDV PFRA/EDV AT DT IVRT
3.1 ± 0.6/s 1.8 ± 0.9/s 194 ± 60 ms 159 ± 60 ms 62 ± 41 ms
IVRT/HR
1.04 ± 1.13
3.0 ± 0.7/s 1.56 ± 0.7/s 165 ± 42 ms 149 ± 40 ms 71 ± 38 ms
>0.05 >0.05 =0.03 >0.05 >0.05
1.14 ± 0.6
>0.05
SEV systolic emptying velocity, CI contractility index, PFRE early peak filling rate, PFRA active peak filling rate, E/A PFRE/PFRA ratio, EDV end-diastolic volume, AT acceleration time, DT deceleration time, IVRT Isovolumic relaxation time, HR heart rate
The analysis of ventricular dV/dt curves showed no statistically significant differences between the two populations (Table 3). Atrial volumes were significantly higher in patients with HCM compared to healthy controls: maximum left
atrial volume (p = 0.007) and minimum left atrial volume (p = 0.01). However, only 13 HCM patients had LAVmax higher than the normal range [15]. A statistically significant difference was also observed in the value of HCM in atrial ejection fraction (p 0.05) as was the stroke volume ratio (atrial SV/ventricular SV × 100) (p > 0.05). The analysis of atrial dV/dt curves showed significant differences. In particular, atrial PERE in HCM was −146 ± 53 ml/s versus −227 ± 86 ml/s in controls (p
CARDIAC RADIOLOGY
Assessment of atrial diastolic function in patients with hypertrophic cardiomyopathy by cine magnetic resonance imaging Emanuele Grassedonio · Giancarlo Todiere · Ludovico La Grutta · Patrizia Toia · Giovanni D. Gentile · Massimo Galia · Federico Midiri · Alessia Pepe · Massimo Midiri · Giovanni Donato Aquaro
Received: 10 June 2014 / Accepted: 18 November 2014 / Published online: 10 February 2015 © Italian Society of Medical Radiology 2015
Abstract Purpose This study was conducted to assess the role of atrial function by cardiac magnetic resonance (CMR) for the evaluation of diastolic physiology in patients with hypertrophic cardiomyopathy (HCM) compared to healthy controls. Materials and methods We enrolled 23 consecutive patients affected by HCM and 43 healthy subjects as agematched control cases (CC). CMR was performed through acquisition of cine steady-state free precession sequences using a 1.5-T scanner. Image postprocessing was carried out using Tracking Tool software. Results Atrial volumes were significantly higher in patients with HCM compared to CC: maximum atrial volume (p = 0.007) and minimum atrial volume (p = 0.01). A statistically significant difference was also observed in atrial ejection fraction in patients with HCM (p 0.05
E/A
2.49 ± 1.9
PFRE/EDV PFRA/EDV AT DT IVRT
3.1 ± 0.6/s 1.8 ± 0.9/s 194 ± 60 ms 159 ± 60 ms 62 ± 41 ms
IVRT/HR
1.04 ± 1.13
3.0 ± 0.7/s 1.56 ± 0.7/s 165 ± 42 ms 149 ± 40 ms 71 ± 38 ms
>0.05 >0.05 =0.03 >0.05 >0.05
1.14 ± 0.6
>0.05
SEV systolic emptying velocity, CI contractility index, PFRE early peak filling rate, PFRA active peak filling rate, E/A PFRE/PFRA ratio, EDV end-diastolic volume, AT acceleration time, DT deceleration time, IVRT Isovolumic relaxation time, HR heart rate
The analysis of ventricular dV/dt curves showed no statistically significant differences between the two populations (Table 3). Atrial volumes were significantly higher in patients with HCM compared to healthy controls: maximum left
atrial volume (p = 0.007) and minimum left atrial volume (p = 0.01). However, only 13 HCM patients had LAVmax higher than the normal range [15]. A statistically significant difference was also observed in the value of HCM in atrial ejection fraction (p 0.05) as was the stroke volume ratio (atrial SV/ventricular SV × 100) (p > 0.05). The analysis of atrial dV/dt curves showed significant differences. In particular, atrial PERE in HCM was −146 ± 53 ml/s versus −227 ± 86 ml/s in controls (p
