de la limite sup.rieure de la normale). Pour ce qui est du facteur de retour au travail, on r.visa r6trospectivement l'influence d'un programme de rehabilitation sur une p.riode de 5 ans (1972-1977). Parmi les 345 candidats admis, 213 .taient atteints d'une cardiopathie isch.mique (55 angineux en phase chronique, ou souffrant d'angine instable, 117 victimes d'infarctus du myocarde, 39 pont.s). De ce nombre, 18 ont 6t. exclus parce qu'ils avajent plus de 65 ans. Cette etude confirme les donn.es actuelies touchant l'effet du conditionnement sur Ia capacit. fonctionnelle des coronariens. A cet .l.ment s'ajoute l'effet de th6rapie de groupe qui permet aux patients de reprendre confiance en eux-m&mes et de suivre leur .volution et celle de leurs compagnons. Plus de chance Parmi les facteurs qui limitent les possibilit.s de rehabilitation, on note 1'.ge, le type d'emploi et Ia dur6e de I'invalidit. avant d'entreprendre la rehabilitation. Cet .l.ment sera repris et mis en relief par le Dr David. Bref, un tel programme, resume le Dr Migneault, am.liore Ia sensation de bien-&re et permet de pr6venir ou de contr6ler les stats d.pressifs qui compromettent souvent le retour au travail. Ii a plus de chances de succ.s aupr.s des patients de moms de 55 ans; pour ce qui est de Ia pr& vention des rechutes et de l'allongement de la long.vit., il faudra attendre les r.sultats de l'6tude du National Exercise and Heart Disease des Etats-Unis attendus pour 1980. Une 6tude de l'ICM publi.e en 1974, portant sur les quelque 500 premiers b.n6ficiaires du pontage aorto-coronarien (septembre 1969 . d.cembre 1972), avait d.montr. que 58% d'entre eux .taient retourn.s au travail au moment de l'en-

quote. Une deuxi.me 6tude portant sur 1534 op.r.s entre janvier 1973 et septembre 1977, a voulu verifier l'influence des progr.s techniques de cette op.$ration sur le facteur de retour au travail. Les r.sultats de cette 6tude ont r.v6k que 63% des patients travaillaient, 25% n'ont jamais travailk apr.s l'op.ration, alors que 12% ont repris le travail mais ont di. l'abandonner par la suite. Leur age moyen .tait de 53.2 ans et us ont . suivis sur une p.riode de 39 mois. Une etude de divers facteurs a permis de mieux cerner leurs relations avec le taux de retour au travail. Fait significatif, 90% de ceux qui ont arr.t. de travailler et 83% de ceux qui n'ont pas travaill. se disent en tr.s bonne ou en bonne sante. Pour ce qui est de l'attitude des employeurs, on constate que 77% de ceux qui n'ont jamais repris le travail Ia jugent positive. Quant au type de travail, 69% de ceux dont l'emploi exige un effort physique mod.r. et 54% de ceux dont l'emploi exige un effort physique consid.rable, sont encore au travail. Si l'on consid.re le facteur age, on constate que plus le patient est jeune, plus ses chances de retour au travail sont grandes, encore que 25% des patients &g.s de 20 .i 49 ans et 38% de ceux qui ont entre 50 et 59 ans, ne travaillent pas. La scolarit. semble influencer le retour au travail; en effet, 58% de ceux dont la scolarit. est inf.rieure .i 12 ans et 82% de ceux dont la scolarit6 est sup.rieure . 13 ans, travaillent. Toutefois, ce sont les facteurs d'inactivit. pr6op.ratoire et de convalescence postop.ratoire qui apparaissent les plus determinants. Le pourcentage de retour au travail passe de 77% . 63% et .i 38%, selon que 1'inactivit. pr.op.ratoire a

de 0 .i 3 mois, de 4 . 6 mois ou de plus de 7 mois. Si la convalescence dure moms de 6 mois, le retour au travail est de 87%, mais ii tombe .t 13% si la convalescence s'6tend au-del& de 7 mois. Une vie normale L'am6lioration des techniques op.ratoires a fait passer le taux de d.c.s de 12.6% (etude de 1974) .i 5.6% (etude de 1978) et l'age moyen au moment de l'intervcntion est passe de 52.8 ans . 50 ans, mais le pourcentage de retour au travail n'a pas 6t. .lev. de fa.on significative. Si 1'on consid.re le coi.t .conomique de cette intervention - a l'ICM, le coiit de chaque pontage 6tait 6valu. en 1978 & $7000, ce qui inclut tous les frais de 21 jours d'hospitalisation - il parait justifi. de vouloir en am.liorer les effets sur le facteur de retour & une vie normale et productive. Le Dr David pr&onise, pour corri,ger cette situation, la prise en charge, par une .quipe pluridisciplinaire d'un service sp.cialis6 de rehabilitation, de tout malade de moms de 60 ans dont l'op.ration a .t6 jug.e m.dicalement r.ussie: "A notre avis, les d.penses d'un service de rehabilitation cardiaque seront largement compens.es par les gains engendr.s par un travail r.mun6rateur et une diminution importante de b.n.fices sociaux." Ii existe actuellement un programme-pilote de rehabilitation auquel participent travailleurs sociaux, psychologues et th6rapeutes. Le Dr David souligne enfin 1'importance de l'.l.ment psychologique et du r6le de Ia famille souvent port6e & surprot.ger le b& n.ficiaire d'un pontage; ii importe de redonner confiance & ce dernier et les exercices physiques s'av.rent un facteur non negligeable.E

Assessing the properties of implant materials: what needs to be done? DAVID WOODS A growing range of metals, plastics and other materials is being implanted or applied to the human body, and enough concern has been generated for these biomaterials to

be the subject of a 2-day workshop Welfare, the Canadian Association in May in Toronto. of Manufacturers of Medical DeThe workshop was sponsored by vices and the Canadian Biomaterials the health protection branch, De- Society. Those attending called for partment of National Health and interdisciplinary cooperation in re-

230 CMA JOURNAL/JULY 21, 1979/VOL. 121

search, testing, standards-setting and education of those involved - as well as of the public. In his opening address, Dr. R. Brian Holmes, dean of medicine at the University of Toronto, credited the dental profession with being the pioneers in biomaterials (there were references during the 2 days to George Washington's wooden teeth). Holmes proposed improved gathering and exchange of data, particularly data on the safety and si4itability of implants, and he urged heightened public awareness of biocompatibility and greater support for research. Granting bodies "tend to fall down" in funding multidisciplinary research, Holmes told the 100-plus delegates. Limited testing Describing a survey conducted by the association, CAMMD president Dr. Bill Williams confirmed that the 124 responses showed there is limited testing of biomaterials in Canada. "The impact of biomaterials is poorly understood," he said. Dr. Derek W. Jones of Dalhousie University's faculty of dentistry described ceramics implants - calcium aluminate, sulfate and phosphate as well as various bioglass compositions - as having the advantage of chemical inertness and the mechanical disadvantage of limited elasticity. Another dentistry faculty member, Dr. Robert Pilliar of the University of Toronto, described the pros and cons of metal as a biomaterial, noting its current application in dental, orthopedic, cardiovascular, ophthalmologic, otolaryngolic and obstetric-gynecologic areas. Metal, he said, offers strength, fracture toughness, fatigue resistance, ductility - and formability into various shapes. Against those factors are metal's corrosive properties, stiffness and possible trace-element effect. Since most metal implants have to absorb considerable stress, said Pilliar, and they can fracture because of improper fitting or because of changes in bone structure, there's a need to develop even greater fatigue resistance and to eliminate loosening. Dr. Pierre Blais of the health pro-

tection branch's bureau of medical devices said polymers offer more scope for custom-designed implants, but they can be erratic and temperamental substances. Blais listed as biocompatibility factors toxicity, deterioration in vivo, extractability, immune and inflammatory response, radiation emission, absorbtion, adsorbtion and the ease with which the material can be sterilized. Dr. Walter Zingg, head of surgical research at Toronto's Hospital for Sick Children and president of the Canadian Biomaterials Society, said that probably no biomaterial will be compatible 100% of the time. "What we're looking at," he said, "is tolerance. After using implants for years we still know little about interactions." Zingg referred to the difficulty of obtaining absolutely clean surfaces, and of the need to understand not only the bulk, but the surface properties of substances at time of implant. Little is known, he said, about how cells respond to different shapes of implants, or about carcinogenic and allergic factors. He called for standardized testing procedures, international exchange of information, and for what he called a "dynamic equilibrium" for implants, given that total acceptance by the body is rarely if ever achievable. Remarkable consensus

labelling and "no differentiation for foreign source data concerning biomaterials." The nephrologists agreed that standards for products and equipment in their field should be determined "through voluntary compliance based on state-of-the-art acceptability, that there is no solid data base upon which to develop standards for dialyzers but "any attempt to set up standards at this time would be counterproductive to progress . . since nephrologists are knowledgeable in these areas and are the only persons delivering dialysis treatment." This group coined what might serve as a motto for most if not all the specialty subworkshops - "not regulation, just education... Centring their discussion mainly on contact lenses, the ophthalmologists urged better patient education; they also called for more contact with manufacturers when a product incites an adverse effect and for clinical trials of devices to be conducted using a protocol similar to that for drugs. The main problem for the plastic surgery group was the matter of silicone implants left permanently in the body. In breast augmentation and postmastectomy reconstruction, for example, little is known about long-term follow-up. The group wants mandatory chemical analysis of products, specific guidelines for investigation of products prior to use and specific guidelines for patients. The cardiovascular group called for a directory of information that would encourage free exchange between user, manufacturer and researcher, development of a Canadian biomaterials industry, high priority for research funding and stimulation of "positive public interest" in biomaterials and medical technology.

The reports from eight subworkshops representing medical-surgical specialties and dentistry showed a remarkable consensus. From the one on orthopedics came the view that further regulation is neither necessary nor desirable, and that goveminent's role should be in communication, coordination and funding; the workshop report also called for further studies into retrieval of orthopedic implants. The dentists wanted more information released on safety and effi- Cerebeflar unpiants cacy, improved liaison between government and the dental trade and Addressing mainly the matter of profession and possible financing cerebellar implants, the neurologists by manufacturers of testing pro- also focused on awareness, educagrams. The gynecologists recom- tion and collaborative standards-setmended collection and analysis of ting. implanted material and a CMA- and The dentists, asserting that 99% Royal College-supported education- of the biomaterials they use are imal program in support of this concept; they asked for more-explicit continued on page 242 CMA JOURNAL/JULY 21, 1979/VOL 121 231

Falls, May 30 to June 2. Dr. Whelan, 43, is a 1968 graduate of Dalhousie University. He has a radiology practice at St. Clare's Mercy Hospital in St. John's, and he has been involved with the NMA for 6 years, 2 as a member of the executive, 3 as honorary secretary and last year as president elect. He and his wife, Betty-Lou, have 2 children. Other members of the executive are Dr. G.W. Warren of Corner Brook, president elect, Dr. T.G. Hogan of St. John's, honorary treasurer, Dr. P.J. Dobbin of St. John's, honorary secretary, Dr. W.R. Stevenson of Grand Bank, past president. Members of the executive are: Dr. Ian Tough, Dr. D.B. Peddle, Dr. J.A. Hopkins, Dr. J. Braganza, Dr. F. French, Dr. D. Norman, Dr. D. McCutcheon, Dr. I. Bowmer, Dr. J. Guy, Dr. M. Bense, Dr. N. Harvey, Dr. G. Fowlow. The NMA representative to the Canadian Medical Association is Dr. John R. Martin. The Distinguished Award Service Brandon from has University been awarded to Dr. Robert E. Beamish of the Winnipeg Health Sciences Centre decardiology dAb Dr. partment. Beamish Beamish, 63, is also an associate professor at the iMPLANT MATERIALS continued from page 231 ported, struck a responsive chord in their expressed concern about the lack of a Canadian manufacturing industry. As CAMMD president Dix Will jams commented in an interview: "We rely too heavily on offshore supplies." The themes of independence, liaison and communication-education occurred time and again throughout the 2-day gathering. At a session on regulatory affairs Dr. D. Smith of the University of Toronto's dentistry faculty advocated that each group concerned with biomaterials should exert primary control over its own standards-setting; he also recoin-

J F

Members of the Federation of Medical Women of Canada at thefr June 21 2 annual meeting (left to right): seated, Drs Enid MacLeod, Eileen Cambon, Eva MacDonald, Frances Forrest Richards (past president), Christina Hill (treasurer), Elizabeth Pollonetsky (president), standing, Drs. Janet Ross, Carole Guzman, Betty Patriarche, Hedy Fry, Lilian Lome.

University of Manitoba and vice president of medical and underwriting, Great West Life Assurance. As well as having been a past president of the Manitoba Medical Association and of the Manitoba College of Physicians and Surgeons, Dr. Beamish has been involved with many community services, medical and nonmedical. He is a 1942 graduate of the University of Manitoba. Dr. Beamish and his wife, Mary Kathleen, have 3 daughters.

A new staff member at CMA house is Donald

G. Price, who took up his duties as assistant prodirector, gram ManageD May 22. rn in Bellelived

he

has

Appointed medical director, Ortho Pharmaceutical Canada Ltd. is Dr. Stephen Boyd of Oakville, Ontario. A 1974 graduate of the University of Toronto, Dr. Boyd practised in Qakville before joining Ortho. He will be responsible for directing Canadian clinical research.

in Niagara Falls, Saint John, Kingston and Montreal. Mr. Price received his BSc from Queen.s in 1974 and his MBA in 1977. After teaching a course in statistics for one term at Queen's, he was sponsored by the Niagara Falls Rotary Club on a 1978 graduate Rotary fellowship to the Australia National University in Canberra. In March he returned to Canada via India, Egypt and Europe.E

mended setting up a centre for biomaterials research. Dr. J.L. Leray of France, vicepresident of the European Society of Biomaterials, stressed the need for international information exchange and, since effective testing might be beyond the capacity of individual nations, multinational collaboration. He invited delegates to attend the first world conference on biomaterials, to be held next year in Vienna. Speaking on behalf of industry, G.W. Pay, vice president and general manager of Madsen Electronics (Canada) Ltd., said that manufacturers are regulated under federal law but that there's still a need for sharper definition of industry's responsibility.

From the government's standpoint Dr. R.W. Campbell, chief of medicine in the Department of National Health and Welfare's bureau of medical devices, said that until 5 years ago the biocompatibility situation was "chaotic" but that considerable strides have been made in international cooperation, testing and documentation. Summing up the workshop, Dr. Bill Williams called for stepped-up involvement by the professions, especially researchers, in biomaterials. He called for expanded testing to keep up with - or ahead of - their burgeoning use, and for a pooling of knowledge by government, the professions and industry.E

242 CMA JOURNAL/JULY 21, 1979/VOL. 121

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Assessing the properties of implant materials: what needs to be done?

de la limite sup.rieure de la normale). Pour ce qui est du facteur de retour au travail, on r.visa r6trospectivement l'influence d'un programme de reh...
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