Clinical Infectious Diseases Advance Access published March 31, 2015

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Assessing the likely impact of a rotavirus vaccination programme in England; the

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contribution of syndromic surveillance

Zharain Bawaa, Alex J. Elliota, Roger A. Morbeya , Shamez Ladhanib, Nigel A. Cunliffec,

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Sarah J. O’Briend, Martyn Regane, Gillian E. Smitha

Real-time Syndromic Surveillance Team, Centre for Infectious Disease Surveillance and

Control, Public Health England, Birmingham B3 2PW, UK b

Immunisation, Hepatitis and Blood Safety Department, Centre for Infectious Disease

Surveillance and Control, Public Health England, London NW9 5EQ, UK

Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health,

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University of Liverpool, Liverpool L69 7EB, UK d

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Epidemiology and Population Health, Institute of Infection and Global Health, University of

Liverpool, Liverpool L69 7EB, UK e

Greater Manchester Centre, Public Health England, Manchester M1 3BN, UK

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Corresponding author: Alex Elliot [email protected]; phone +44 (0)121 232 9211. Alternative corresponding author: Gillian Smith [email protected]; phone +44 (0)844

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225 3560; fax +44 (0)121 236 2215.

© Crown copyright 2015.

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Article summary Syndromic surveillance was used to assess the likely impact of a new rotavirus vaccine

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programme in England. General practitioner consultations and emergency department attendances for gastroenteritis, diarrhoea and vomiting were significantly lower in young

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children during the first rotavirus season following the introduction of the vaccine.

Abstract

Background. In July 2013, a rotavirus vaccination programme for 2-3 month olds was introduced in the UK. We present an initial impact analysis of this new vaccine programme

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using national syndromic surveillance systems.

Methods. General practitioner in hours (GPIH), out of hours (GPOOH) and emergency

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department (ED) syndromic surveillance systems were used to monitor GP consultations and ED attendances for gastroenteritis, diarrhoea and vomiting. Data were stratified by age group and compared between pre- and post-vaccine year rotavirus seasons. Incidence rate ratios (IRRs) and percentage ratios were calculated for GPIH consultations and GPOOH and ED

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data, respectively.

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Results. There was a significant reduction in gastroenteritis, diarrhoea and vomiting GPIH consultations in the 0-4 years age group when comparing the rotavirus season in the pre- and post-vaccine years (p value