Original Article
Biomol Ther 22(6), 510-518 (2014)
Arsenite Acutely Decreases Nitric Oxide Production via the ROS—Protein Phosphatase 1—Endothelial Nitric Oxide Synthase-Thr497 Signaling Cascade Jungwon Seo1,2, Jee Young Lee1, Min-Sun Sung1, Catherine Jeonghae Byun1, Du-Hyong Cho3, Hyeon-Ju Lee1, Jung-Hyun Park1, Ho-Seong Cho4, Sung-Jin Cho5 and Inho Jo1,* Department of Molecular Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, 3 Department of Pharmacology, School of Medicine, Eulji University, Daejeon 301-768, 4 Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University, Jeonju 561-756, 5 Department of Biology, College of Natural Sciences, Chungbuk National University, Cheongju 362-763, Republic of Korea 1 2
Abstract Chronic (>24 h) exposure of arsenite, an environmental toxicant, has shown the decreased nitric oxide (NO) production in endothelial cells (EC) by decreasing endothelial NO synthase (eNOS) expression and/or its phosphorylation at serine 1179 (eNOSSer1179 in bovine sequence), which is associated with increased risk of vascular diseases. Here, we investigated the acute (
Biomol Ther 22(6), 510-518 (2014)
Arsenite Acutely Decreases Nitric Oxide Production via the ROS—Protein Phosphatase 1—Endothelial Nitric Oxide Synthase-Thr497 Signaling Cascade Jungwon Seo1,2, Jee Young Lee1, Min-Sun Sung1, Catherine Jeonghae Byun1, Du-Hyong Cho3, Hyeon-Ju Lee1, Jung-Hyun Park1, Ho-Seong Cho4, Sung-Jin Cho5 and Inho Jo1,* Department of Molecular Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, 3 Department of Pharmacology, School of Medicine, Eulji University, Daejeon 301-768, 4 Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University, Jeonju 561-756, 5 Department of Biology, College of Natural Sciences, Chungbuk National University, Cheongju 362-763, Republic of Korea 1 2
Abstract Chronic (>24 h) exposure of arsenite, an environmental toxicant, has shown the decreased nitric oxide (NO) production in endothelial cells (EC) by decreasing endothelial NO synthase (eNOS) expression and/or its phosphorylation at serine 1179 (eNOSSer1179 in bovine sequence), which is associated with increased risk of vascular diseases. Here, we investigated the acute (
