Accepted Manuscript Title: Apparent Diffusion Coefficient Value of Gastric Cancer by Diffusion-Weighted Imaging: Correlations with the Histological Differentiation and Lauren Classification Authors: Song Liu MD Wenxian Guan MD, PhD Hao Wang MD, PhD Liang Pan MD Zhuping Zhou MD Haiping Yu MD Tian Liu MD, PhD Xiaofeng Yang MD, PhD Jian He MD, PhD Zhengyang Zhou MD, PhD PII: DOI: Reference:
S0720-048X(14)00465-3 http://dx.doi.org/doi:10.1016/j.ejrad.2014.09.021 EURR 6904
To appear in:
European Journal of Radiology
Received date: Revised date: Accepted date:
6-6-2014 3-9-2014 29-9-2014
Please cite this article as: Liu S, Guan W, Wang H, Pan L, Zhou Z, Yu H, Liu T, Yang X, He J, Zhou Z, Apparent Diffusion Coefficient Value of Gastric Cancer by Diffusion-Weighted Imaging: Correlations with the Histological Differentiation and Lauren Classification, European Journal of Radiology (2014), http://dx.doi.org/10.1016/j.ejrad.2014.09.021 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Apparent Diffusion Coefficient Value of Gastric Cancer by Diffusion-Weighted Imaging: Correlations with the Histological Differentiation and Lauren Classification
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Song Liu, MD 1, a, Wenxian Guan, MD, PhD 2, a, Hao Wang, MD, PhD 2, Liang Pan, MD 1, Zhuping Zhou, MD 1, Haiping Yu, MD 1, Tian Liu, MD, PhD 3, Xiaofeng Yang, MD, PhD 3, Jian He, MD,
Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing
us
1
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PhD1, *, Zhengyang Zhou MD, PhD 1, *
University Medical School, Nanjing, China, 210008
Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of
an
2
M
Nanjing University Medical School, Nanjing, China, 210008
Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA, 30322
a
Both authors contributed equally to this manuscript.
*
Corresponding authors: Jian He, Ph.D., M.D. and Zhengyang Zhou, Ph.D., M.D.
te
d
3
Ac ce p
Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
No. 321 Zhongshan Road, Nanjing 210008, P. R. China
Tel: +862583597160
Fax: +86253317761
E-mail: [email protected] (Jian He), [email protected] (Zhengyang Zhou)
The e-mail address of each author: Song Liu, M.D. (first author)
Page 1 of 30
E-mail address: [email protected]
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Wenxian Guan, Ph.D., M.D. (joint first author)
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E-mail address: [email protected]
us
Hao Wang, Ph.D., M.D.
an
E-mail address: [email protected]
E-mail address: [email protected]
te
d
Zhuping Zhou, M.D.
M
Liang Pan, M.D.
Ac ce p
E-mail address: [email protected]
Haiping Yu, M.D.
E-mail address: [email protected]
Tian Liu, Ph.D., M.D.
E-mail address: [email protected]
Xiaofeng Yang, Ph.D., M.D. E-mail address: [email protected]
Page 2 of 30
Jian He, Ph.D., M.D. (corresponding author)
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E-mail address: [email protected]
cr
Zhengyang Zhou, Ph.D., M.D. (corresponding author)
Ac ce p
te
d
M
an
us
E-mail address: [email protected]
Page 3 of 30
Apparent Diffusion Coefficient Value of Gastric Cancer by Diffusion-Weighted Imaging: Correlations with the Histological Differentiation and Lauren Classification
ip t
Abstract Objective: The purpose of this study was to evaluate the correlations between histological
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differentiation and Lauren classification of gastric cancer and the apparent diffusion coefficient (ADC)
us
value of diffusion weighted imaging (DWI).
Materials and Methods: Sixty-nine patients with gastric cancer lesions underwent preoperative
an
magnetic resonance imaging (MRI) (3.0T) and surgical resection. DWI was obtained with a single-shot,
M
echo-planar imaging sequence in the axial plane (b values: 0 and 1,000 sec/mm2). Mean and minimum ADC values were obtained for each gastric cancer and normal gastric walls by two radiologists, who
d
were blinded to the histological findings. Histological type, degree of differentiation and Lauren
te
classification of each resected specimen were determined by one pathologist. Mean and minimum ADC
Ac ce p
values of gastric cancers with different histological types, degrees of differentiation and Lauren classifications were compared. Correlations between ADC values and histological differentiation and Lauren classification were analyzed.
Results: The mean and minimum ADC values of gastric cancers, as a whole and separately, were
significantly lower than those of normal gastric walls (all p values
S0720-048X(14)00465-3 http://dx.doi.org/doi:10.1016/j.ejrad.2014.09.021 EURR 6904
To appear in:
European Journal of Radiology
Received date: Revised date: Accepted date:
6-6-2014 3-9-2014 29-9-2014
Please cite this article as: Liu S, Guan W, Wang H, Pan L, Zhou Z, Yu H, Liu T, Yang X, He J, Zhou Z, Apparent Diffusion Coefficient Value of Gastric Cancer by Diffusion-Weighted Imaging: Correlations with the Histological Differentiation and Lauren Classification, European Journal of Radiology (2014), http://dx.doi.org/10.1016/j.ejrad.2014.09.021 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Apparent Diffusion Coefficient Value of Gastric Cancer by Diffusion-Weighted Imaging: Correlations with the Histological Differentiation and Lauren Classification
ip t
Song Liu, MD 1, a, Wenxian Guan, MD, PhD 2, a, Hao Wang, MD, PhD 2, Liang Pan, MD 1, Zhuping Zhou, MD 1, Haiping Yu, MD 1, Tian Liu, MD, PhD 3, Xiaofeng Yang, MD, PhD 3, Jian He, MD,
Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing
us
1
cr
PhD1, *, Zhengyang Zhou MD, PhD 1, *
University Medical School, Nanjing, China, 210008
Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of
an
2
M
Nanjing University Medical School, Nanjing, China, 210008
Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA, 30322
a
Both authors contributed equally to this manuscript.
*
Corresponding authors: Jian He, Ph.D., M.D. and Zhengyang Zhou, Ph.D., M.D.
te
d
3
Ac ce p
Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
No. 321 Zhongshan Road, Nanjing 210008, P. R. China
Tel: +862583597160
Fax: +86253317761
E-mail: [email protected] (Jian He), [email protected] (Zhengyang Zhou)
The e-mail address of each author: Song Liu, M.D. (first author)
Page 1 of 30
E-mail address: [email protected]
ip t
Wenxian Guan, Ph.D., M.D. (joint first author)
cr
E-mail address: [email protected]
us
Hao Wang, Ph.D., M.D.
an
E-mail address: [email protected]
E-mail address: [email protected]
te
d
Zhuping Zhou, M.D.
M
Liang Pan, M.D.
Ac ce p
E-mail address: [email protected]
Haiping Yu, M.D.
E-mail address: [email protected]
Tian Liu, Ph.D., M.D.
E-mail address: [email protected]
Xiaofeng Yang, Ph.D., M.D. E-mail address: [email protected]
Page 2 of 30
Jian He, Ph.D., M.D. (corresponding author)
ip t
E-mail address: [email protected]
cr
Zhengyang Zhou, Ph.D., M.D. (corresponding author)
Ac ce p
te
d
M
an
us
E-mail address: [email protected]
Page 3 of 30
Apparent Diffusion Coefficient Value of Gastric Cancer by Diffusion-Weighted Imaging: Correlations with the Histological Differentiation and Lauren Classification
ip t
Abstract Objective: The purpose of this study was to evaluate the correlations between histological
cr
differentiation and Lauren classification of gastric cancer and the apparent diffusion coefficient (ADC)
us
value of diffusion weighted imaging (DWI).
Materials and Methods: Sixty-nine patients with gastric cancer lesions underwent preoperative
an
magnetic resonance imaging (MRI) (3.0T) and surgical resection. DWI was obtained with a single-shot,
M
echo-planar imaging sequence in the axial plane (b values: 0 and 1,000 sec/mm2). Mean and minimum ADC values were obtained for each gastric cancer and normal gastric walls by two radiologists, who
d
were blinded to the histological findings. Histological type, degree of differentiation and Lauren
te
classification of each resected specimen were determined by one pathologist. Mean and minimum ADC
Ac ce p
values of gastric cancers with different histological types, degrees of differentiation and Lauren classifications were compared. Correlations between ADC values and histological differentiation and Lauren classification were analyzed.
Results: The mean and minimum ADC values of gastric cancers, as a whole and separately, were
significantly lower than those of normal gastric walls (all p values
