Scandinavian Journal of Clinical and Laboratory Investigation
ISSN: 0036-5513 (Print) 1502-7686 (Online) Journal homepage: http://www.tandfonline.com/loi/iclb20
Apolipoprotein(a) in insulin-dependent diabetic patients with and without diabetic nephropathy M-A. Gall, P. Rossing, E. Hommel, A. I. Voldsgaard, P. Andersen, F. S. Nielsen, J. Dyerberg & H-H. Parving To cite this article: M-A. Gall, P. Rossing, E. Hommel, A. I. Voldsgaard, P. Andersen, F. S. Nielsen, J. Dyerberg & H-H. Parving (1992) Apolipoprotein(a) in insulin-dependent diabetic patients with and without diabetic nephropathy, Scandinavian Journal of Clinical and Laboratory Investigation, 52:6, 513-521 To link to this article: http://dx.doi.org/10.3109/00365519209090129
Published online: 08 Jul 2009.
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Date: 07 November 2015, At: 09:15
Scand J Clin Lab Invest 1992; 52: 513-521
Apolipoprotein( a) in insulin-dependent diabetic patients with and without diabetic nephropathy M-A. G A L L , * P. ROSSING,.* E . H O M M E L , " A . 1. V O L D S G A A R D , * P . A N D E R S E N , * F. S . NIELSEN,* J . D Y E R B E R G t & H-H. PARVING*
Downloaded by [Australian National University] at 09:15 07 November 2015
*Steno Memorial and Hvidore Hospital, Klampenborg, Denmark, and l.Medi-Lab a.s., Copenhagen, Denmark
Gall M-A, Rossing P, Hommel E, Voldsgaard AI, Andersen P, Nielsen FS, Dyerberg J, Parving H-H. Apolipoprotein(a) in insulin-dependent diabetic patients with or without diabetic nephropathy. Scand J Clin Lab Invest 1992; 52: 513-521. Insulin-dependent diabetic patients with diabetic nephropathy have a highly increased morbidity and mortality from cardiovascular diseases. To determine whether altered levels of apolipoprotein(a) (apo(a)), the glycoprotein of the potentially atherogenic lipoprotein(a) (Lp(a)), contribute to the increased risk of ischaemic heart disease, apo(a) was determined in 50 insulin-dependent diabetic patients with diabetic nephropathy (group l ) , in 50 insulin-dependent diabetic patients with microalbuminuria (group 2), in 50 insulin-dependent diabetic patients with normoalbuminuria (group 3), and in 50 healthy subjects (group 4). The groups were matched with regard to sex, age and body mass index. The diabetic groups were also matched with regard to diabetes duration. The level of apo(a) was approximately the same in the four groups, being: 122 ( W t 4 . 2 ) U I-', 63 (X/s4.4) U I-', 128 (X/+3.5) U I-' and 126 (X/+3.7) U I-' (geometric mean (x/+antilog SD)) in group I , 2, 3 and 4, respectively. 1 U I-' apo(a) approximates 0.7 mg I-' Lp(a). The serum concentration of the following apolipoproteins and lipids was higher in patients with nephropathy as compared to the threeothergroups(group 1 vsgroup3): apolipoproteinB 1 . 3 6 k 0 . 3 8 1.11kO.30 ~~ g I-' (meankSD) (p
ISSN: 0036-5513 (Print) 1502-7686 (Online) Journal homepage: http://www.tandfonline.com/loi/iclb20
Apolipoprotein(a) in insulin-dependent diabetic patients with and without diabetic nephropathy M-A. Gall, P. Rossing, E. Hommel, A. I. Voldsgaard, P. Andersen, F. S. Nielsen, J. Dyerberg & H-H. Parving To cite this article: M-A. Gall, P. Rossing, E. Hommel, A. I. Voldsgaard, P. Andersen, F. S. Nielsen, J. Dyerberg & H-H. Parving (1992) Apolipoprotein(a) in insulin-dependent diabetic patients with and without diabetic nephropathy, Scandinavian Journal of Clinical and Laboratory Investigation, 52:6, 513-521 To link to this article: http://dx.doi.org/10.3109/00365519209090129
Published online: 08 Jul 2009.
Submit your article to this journal
Article views: 1
View related articles
Citing articles: 2 View citing articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=iclb20 Download by: [Australian National University]
Date: 07 November 2015, At: 09:15
Scand J Clin Lab Invest 1992; 52: 513-521
Apolipoprotein( a) in insulin-dependent diabetic patients with and without diabetic nephropathy M-A. G A L L , * P. ROSSING,.* E . H O M M E L , " A . 1. V O L D S G A A R D , * P . A N D E R S E N , * F. S . NIELSEN,* J . D Y E R B E R G t & H-H. PARVING*
Downloaded by [Australian National University] at 09:15 07 November 2015
*Steno Memorial and Hvidore Hospital, Klampenborg, Denmark, and l.Medi-Lab a.s., Copenhagen, Denmark
Gall M-A, Rossing P, Hommel E, Voldsgaard AI, Andersen P, Nielsen FS, Dyerberg J, Parving H-H. Apolipoprotein(a) in insulin-dependent diabetic patients with or without diabetic nephropathy. Scand J Clin Lab Invest 1992; 52: 513-521. Insulin-dependent diabetic patients with diabetic nephropathy have a highly increased morbidity and mortality from cardiovascular diseases. To determine whether altered levels of apolipoprotein(a) (apo(a)), the glycoprotein of the potentially atherogenic lipoprotein(a) (Lp(a)), contribute to the increased risk of ischaemic heart disease, apo(a) was determined in 50 insulin-dependent diabetic patients with diabetic nephropathy (group l ) , in 50 insulin-dependent diabetic patients with microalbuminuria (group 2), in 50 insulin-dependent diabetic patients with normoalbuminuria (group 3), and in 50 healthy subjects (group 4). The groups were matched with regard to sex, age and body mass index. The diabetic groups were also matched with regard to diabetes duration. The level of apo(a) was approximately the same in the four groups, being: 122 ( W t 4 . 2 ) U I-', 63 (X/s4.4) U I-', 128 (X/+3.5) U I-' and 126 (X/+3.7) U I-' (geometric mean (x/+antilog SD)) in group I , 2, 3 and 4, respectively. 1 U I-' apo(a) approximates 0.7 mg I-' Lp(a). The serum concentration of the following apolipoproteins and lipids was higher in patients with nephropathy as compared to the threeothergroups(group 1 vsgroup3): apolipoproteinB 1 . 3 6 k 0 . 3 8 1.11kO.30 ~~ g I-' (meankSD) (p
