ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Sept. 1976, Copyright 0 1976 American Society for Microbiology
p.
476-482
Vol. 10, No. 3 Printed in U.S.A.
Antitrichomonad Action, Mutagenicity, and Reduction of Metronidazole and Other Nitroimidazoles DONALD G. LINDMARK* AND MIKLOS
MULLER
The Rockefeller University, New York, New York 10021
Received for publication 26 May 1976
Twelve 4- and 5-nitroimidazole derivatives, including metronidazole and two of its metabolites, tinidazole, dimetridazole, and nimorazole, were tested for antitrichomonad action on Tritrichomonas foetus (KV1) and Trichomonas vaginalis (ATCC 30001) for mutagenicity on a nitroreductase-positive (TA 100) and a nitroreductase-deficient (TA 100-FR1) strain of Salmonella typhimurium, as well as for the reducibility of the nitro group by T. foetus homogenates. Compounds with activity
p.
476-482
Vol. 10, No. 3 Printed in U.S.A.
Antitrichomonad Action, Mutagenicity, and Reduction of Metronidazole and Other Nitroimidazoles DONALD G. LINDMARK* AND MIKLOS
MULLER
The Rockefeller University, New York, New York 10021
Received for publication 26 May 1976
Twelve 4- and 5-nitroimidazole derivatives, including metronidazole and two of its metabolites, tinidazole, dimetridazole, and nimorazole, were tested for antitrichomonad action on Tritrichomonas foetus (KV1) and Trichomonas vaginalis (ATCC 30001) for mutagenicity on a nitroreductase-positive (TA 100) and a nitroreductase-deficient (TA 100-FR1) strain of Salmonella typhimurium, as well as for the reducibility of the nitro group by T. foetus homogenates. Compounds with activity
