Clinical Infectious Diseases Advance Access published January 30, 2015 1
Antiretroviral Treatment Failure, Drug resistance and Subtype Diversity in the only Pediatric HIV
Tanya Rogo1, Allison K. DeLong2, Philip Chan3, Rami Kantor3 1
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Clinic in Rhode Island
Department of Pediatrics, Brown University, Providence, RI, USA Center for Statistical Sciences, Brown University, Providence, RI, USA 3 Division of Infectious Diseases, Brown University, Providence, RI, USA 2
us
Key points (summary):
an
Alternate corresponding author: Rami Kantor, MD, The Miriam Hospital, 164 Summit Avenue, RISE 154, Providence, RI 02906, Telephone number (401) 793-4997, Fax: (401) 793-4709, Email: [email protected]
M
We report 57% treatment failure, 6% transmitted and 73% acquired resistance, 35% non-B subtypes and one epidemiologically-confirmed transmission cluster in the sole pediatric HIV clinic in Rhode Island. These comprehensive results highlight needs to closely monitor children maturing to
Ac
ce
pt ed
adulthood.
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e‐mail: [email protected].
Downloaded from http://cid.oxfordjournals.org/ at University of Sussex on February 2, 2015
Corresponding author: Tanya Rogo, MD, Human Resources for Health Rwanda, c/o Ministry of Health, P.O. Box 84, Kigali, Rwanda, Mobile number +250 (0) 789182943, Email: [email protected]
2
Abstract Background: Drug resistance development in the HIV-infected pediatric population in the United States
cr ipt
can impact long-term antiretroviral therapy (ART) efficacy. Limited formularies and adherence constraints in children jeopardize lifelong-needed ART.
Methods: We examined treatment failure, drug resistance and their correlates in ART naïve and
experienced children attending the pediatric HIV clinic in Rhode Island between 1991-2012. Pol
sequences were obtained for phylogenetic, subtype and resistance analyses. Associations between
us
and Fisher exact tests.
an
Results: Data were available for all 56 clinic-attending children. At diagnosis, 33% were
Antiretroviral Treatment Failure, Drug resistance and Subtype Diversity in the only Pediatric HIV
Tanya Rogo1, Allison K. DeLong2, Philip Chan3, Rami Kantor3 1
cr ipt
Clinic in Rhode Island
Department of Pediatrics, Brown University, Providence, RI, USA Center for Statistical Sciences, Brown University, Providence, RI, USA 3 Division of Infectious Diseases, Brown University, Providence, RI, USA 2
us
Key points (summary):
an
Alternate corresponding author: Rami Kantor, MD, The Miriam Hospital, 164 Summit Avenue, RISE 154, Providence, RI 02906, Telephone number (401) 793-4997, Fax: (401) 793-4709, Email: [email protected]
M
We report 57% treatment failure, 6% transmitted and 73% acquired resistance, 35% non-B subtypes and one epidemiologically-confirmed transmission cluster in the sole pediatric HIV clinic in Rhode Island. These comprehensive results highlight needs to closely monitor children maturing to
Ac
ce
pt ed
adulthood.
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e‐mail: [email protected].
Downloaded from http://cid.oxfordjournals.org/ at University of Sussex on February 2, 2015
Corresponding author: Tanya Rogo, MD, Human Resources for Health Rwanda, c/o Ministry of Health, P.O. Box 84, Kigali, Rwanda, Mobile number +250 (0) 789182943, Email: [email protected]
2
Abstract Background: Drug resistance development in the HIV-infected pediatric population in the United States
cr ipt
can impact long-term antiretroviral therapy (ART) efficacy. Limited formularies and adherence constraints in children jeopardize lifelong-needed ART.
Methods: We examined treatment failure, drug resistance and their correlates in ART naïve and
experienced children attending the pediatric HIV clinic in Rhode Island between 1991-2012. Pol
sequences were obtained for phylogenetic, subtype and resistance analyses. Associations between
us
and Fisher exact tests.
an
Results: Data were available for all 56 clinic-attending children. At diagnosis, 33% were
