Brief Reports
Antipsychotic Formulation and One-Year Rehospitalization of Schizophrenia Patients: A Population-Based Cohort Study Shiau-Shian Huang, M.D. Ching-Heng Lin, Ph.D. El-Wui Loh, Ph.D. Hsin-yu Yang, M.D. Chin Hong Chan, M.D., M.A.M. Tsuo-Hung Lan, M.D., Ph.D.
Objective: The authors compared the efficacy of long-acting injectable antipsychotics and oral antipsychotics on rehospitalization rate of community-dwelling patients with schizophrenia who had frequent admissions. Methods: The cohort study of 14,610 patients was conducted by analyzing the Taiwan National Health Research Institutes data. The patients were divided into groups that received oral antipsychotics (risperidone, a different second-generation antipsychotic, or a first-generation antipsychotic) or long-acting injectable antipsychotics (risperidone, haloperidol, or flupenthixol). Results: One-year rehospitalization rates of the final cohort of 10,552 patients were the same for both groups (by long-acting injection, 27.3%; by oral administration, 27.3%). Secondary analysis of groups receiving long-acting injectable medication showed that haloperidol resulted in lower rehospitalization Dr. Huang, Dr. Yang, Dr. Chan, and Dr. Lan are with the Department of Psychiatry and Dr. Lin is with the Department of Medical Research, Taichung Veterans General Hospital, No. 160, Sec. 3, ChungKang Rd., Taichung 40705, Taiwan (e-mail Dr. Lan: [email protected]). Dr. Lan is also with the School of Medicine, National Yang-Ming University, Taipei. Dr. Loh is with Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung City, Taiwan.
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rates (haloperidol, 22.5%; risperidone, 27.1%; and flupenthixol, 29.5%). Patients’ characteristics, including age, region, and insurance payments were significantly correlated with the risk of relapse (p
Antipsychotic Formulation and One-Year Rehospitalization of Schizophrenia Patients: A Population-Based Cohort Study Shiau-Shian Huang, M.D. Ching-Heng Lin, Ph.D. El-Wui Loh, Ph.D. Hsin-yu Yang, M.D. Chin Hong Chan, M.D., M.A.M. Tsuo-Hung Lan, M.D., Ph.D.
Objective: The authors compared the efficacy of long-acting injectable antipsychotics and oral antipsychotics on rehospitalization rate of community-dwelling patients with schizophrenia who had frequent admissions. Methods: The cohort study of 14,610 patients was conducted by analyzing the Taiwan National Health Research Institutes data. The patients were divided into groups that received oral antipsychotics (risperidone, a different second-generation antipsychotic, or a first-generation antipsychotic) or long-acting injectable antipsychotics (risperidone, haloperidol, or flupenthixol). Results: One-year rehospitalization rates of the final cohort of 10,552 patients were the same for both groups (by long-acting injection, 27.3%; by oral administration, 27.3%). Secondary analysis of groups receiving long-acting injectable medication showed that haloperidol resulted in lower rehospitalization Dr. Huang, Dr. Yang, Dr. Chan, and Dr. Lan are with the Department of Psychiatry and Dr. Lin is with the Department of Medical Research, Taichung Veterans General Hospital, No. 160, Sec. 3, ChungKang Rd., Taichung 40705, Taiwan (e-mail Dr. Lan: [email protected]). Dr. Lan is also with the School of Medicine, National Yang-Ming University, Taipei. Dr. Loh is with Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung City, Taiwan.
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rates (haloperidol, 22.5%; risperidone, 27.1%; and flupenthixol, 29.5%). Patients’ characteristics, including age, region, and insurance payments were significantly correlated with the risk of relapse (p
