DIAGN MICROBIOLINFECT DIS 1991;14:301-309
301
Antimicrobial Activity of E-1040, a Novel Thiadiazolyl Cephalosporin Compared with Other Parenteral Cephems Ronald N. Jones, Meridith E. Erwin, Mary S. Barrett, David M. Johnson, and Beth M. Briggs
E-1040, a new parenteral fourth-generation cephalosporin, was tested against ~ 600 bacteremic pathogens and compared with cefotaxime, cefiazidime, and cefpirome. E-I040 activity against Staphylococcus aureus was comparable (MICro, 8 i~g/ml) to ceftazidime, but inferior to cefotaxime (MICgo, 2 ~,g/ml) and cefpirome (MICgo, 0.5 I~g/ml). jS-Hemolytic streptococci and most Gram-positive anaerobes were also susceptible to E-1040. Some strains of coagulase-negative staphylococci, all oxacillinresistant Staphylcoccus spp., enterococci, and Bacteroides fragilis group strains were resistant to E-1040 (MICgo, >64 I~g/ml). Comparative tests for E-1040 and the three other cephalosporins against pseudomonads and nonenteric Gramnegative bacilli showed E-1040 to be generally most active. The E-I040 MICgo for Pseudomonas aeruginosa was I
i~g/ml and for ceflazidime it was 4 t~g/ml. Haemophilus influenzae, Moraxella catarrhalis, and Neisseria spp. has E-1040 MICgos ranging from 0.12 to 2 I~g/ml. Neisseria gonorrhoeae, strains resistant to penicillin, did not have markedly elevated E-1040 MICs compared with penicillinsusceptible strains. Enterobacteriaceae species had all MICs of 64 >32 > 16 8
>64 >32 > 16 16
0 17 0 52
30~
E-1040 Cefotaxime Ceftazidime Cefpirome
>64 >32 > 16 > 16
>64 >32 > 16 > 16
0 3 0 3
Staphylococcus aureus Oxacillin susceptible
21
E-1040 Cefotaxime Ceftazidime Cefpirome
Oxacillin resistant
10
E-1040 Cefotaxime Ce ftazidime Ce fpirome
Staphylococcus epidermidis
20
E-1040 Cefotaxime Ceftazidime Cefpirome
Coagulase negative Staphylococcus spp.
46 c
Streptococcus viridans group Streptocuccus pneumoniae penicillin susceptible penicillin resistant
8 1 4 0.5
100 100 95 100
>64 >32 > 16 > 16
0 20 10 30
2 1 4 0.5
16 16 > 16 4
85 85 60 95
E-1040 Cefotaxime Ceftazidime Cefpirome
4 1 8 0.5
>64 >32 > 16 > 16
83 83 73 85
10
E-1040
1
4
100
10
E-1040
0.12
0.12
100
E-1040
0.5
--
100
7a
32 >32 :> 16 16
8 2 8 0.5
Streptococcus spp., f~-Hemolytic Serogroup A
10
E-1040
0.06
0.06
100
Serogroup B
10
E-1040
0.25
0.25
100
Serogroup C, F, and G
17
E-1040
0.06
2
100
15e
E-1040
1
32
80
Gram-positive anaerobes
aBreakpoint MIC criteria fo the NCCLS (1990a and b). E-1040 criteria were susceptible ~32 p.g/ml, for example, comparable criteria to other parenteral cephalosporins. blncludes E. faecium (120 strains), E. raffinosus (5 strains), E. casseliflavus (5 strains), E. gallinarum (5 strains), E. durans (2 strains), E. hirae (2 strains), and E. avium (1 strain). qncludes S. capitis (6 strains), S. haemolyticus (10 strains), S. hominis (9 strains), S. simulans (6 stains), S. saprophyticus (4 strains), S. warneri (7 strains), S. xylosis (2 strains), S. sciuri (1 strain), and S. auricularis (1 strain). dPenicillin MICs of I>0.12 ~.g/ml and an oxacillin 1-~g zone disk diameter of ~16 >16 >16 > 16 >16 >16 ">16 >16 >16 >16 >16
~ 0.25 4 >16 32 > 32 16 16 >32 4 2 0.5 4
0.12 0.12 0.12 0.12 0.12 0.12 {I. 12 0.12 0.12 0.12 0.12 0.12
0.12 O. 12
301
Antimicrobial Activity of E-1040, a Novel Thiadiazolyl Cephalosporin Compared with Other Parenteral Cephems Ronald N. Jones, Meridith E. Erwin, Mary S. Barrett, David M. Johnson, and Beth M. Briggs
E-1040, a new parenteral fourth-generation cephalosporin, was tested against ~ 600 bacteremic pathogens and compared with cefotaxime, cefiazidime, and cefpirome. E-I040 activity against Staphylococcus aureus was comparable (MICro, 8 i~g/ml) to ceftazidime, but inferior to cefotaxime (MICgo, 2 ~,g/ml) and cefpirome (MICgo, 0.5 I~g/ml). jS-Hemolytic streptococci and most Gram-positive anaerobes were also susceptible to E-1040. Some strains of coagulase-negative staphylococci, all oxacillinresistant Staphylcoccus spp., enterococci, and Bacteroides fragilis group strains were resistant to E-1040 (MICgo, >64 I~g/ml). Comparative tests for E-1040 and the three other cephalosporins against pseudomonads and nonenteric Gramnegative bacilli showed E-1040 to be generally most active. The E-I040 MICgo for Pseudomonas aeruginosa was I
i~g/ml and for ceflazidime it was 4 t~g/ml. Haemophilus influenzae, Moraxella catarrhalis, and Neisseria spp. has E-1040 MICgos ranging from 0.12 to 2 I~g/ml. Neisseria gonorrhoeae, strains resistant to penicillin, did not have markedly elevated E-1040 MICs compared with penicillinsusceptible strains. Enterobacteriaceae species had all MICs of 64 >32 > 16 8
>64 >32 > 16 16
0 17 0 52
30~
E-1040 Cefotaxime Ceftazidime Cefpirome
>64 >32 > 16 > 16
>64 >32 > 16 > 16
0 3 0 3
Staphylococcus aureus Oxacillin susceptible
21
E-1040 Cefotaxime Ceftazidime Cefpirome
Oxacillin resistant
10
E-1040 Cefotaxime Ce ftazidime Ce fpirome
Staphylococcus epidermidis
20
E-1040 Cefotaxime Ceftazidime Cefpirome
Coagulase negative Staphylococcus spp.
46 c
Streptococcus viridans group Streptocuccus pneumoniae penicillin susceptible penicillin resistant
8 1 4 0.5
100 100 95 100
>64 >32 > 16 > 16
0 20 10 30
2 1 4 0.5
16 16 > 16 4
85 85 60 95
E-1040 Cefotaxime Ceftazidime Cefpirome
4 1 8 0.5
>64 >32 > 16 > 16
83 83 73 85
10
E-1040
1
4
100
10
E-1040
0.12
0.12
100
E-1040
0.5
--
100
7a
32 >32 :> 16 16
8 2 8 0.5
Streptococcus spp., f~-Hemolytic Serogroup A
10
E-1040
0.06
0.06
100
Serogroup B
10
E-1040
0.25
0.25
100
Serogroup C, F, and G
17
E-1040
0.06
2
100
15e
E-1040
1
32
80
Gram-positive anaerobes
aBreakpoint MIC criteria fo the NCCLS (1990a and b). E-1040 criteria were susceptible ~32 p.g/ml, for example, comparable criteria to other parenteral cephalosporins. blncludes E. faecium (120 strains), E. raffinosus (5 strains), E. casseliflavus (5 strains), E. gallinarum (5 strains), E. durans (2 strains), E. hirae (2 strains), and E. avium (1 strain). qncludes S. capitis (6 strains), S. haemolyticus (10 strains), S. hominis (9 strains), S. simulans (6 stains), S. saprophyticus (4 strains), S. warneri (7 strains), S. xylosis (2 strains), S. sciuri (1 strain), and S. auricularis (1 strain). dPenicillin MICs of I>0.12 ~.g/ml and an oxacillin 1-~g zone disk diameter of ~16 >16 >16 > 16 >16 >16 ">16 >16 >16 >16 >16
~ 0.25 4 >16 32 > 32 16 16 >32 4 2 0.5 4
0.12 0.12 0.12 0.12 0.12 0.12 {I. 12 0.12 0.12 0.12 0.12 0.12
0.12 O. 12
