Immunology Letters, 33 (1992) 207-210 0165 - 2478 / 92 / $ 5.00 © 1992 Elsevier Science Publishers B.V. All rights reserved IMLET 01820
Antibodies to reverse transcriptase in HIV infection and progression to AIDS A m i S c h a t t n e r a, R u t h M i l c h a n b, J o s e p h K a m i n c h i k b, Z i v a Y a v i n b a n d Z v i B e n t w i c h a aDivision of Medicine and R. Ben-Ari Institute of Clinical Immunology, Kaplan Hospital, Rehovot, Israel, and Hebrew University and Hadassah Medical School, Jerusalem Israel, and bBiotechnology General (Israel) Ltd., Rehovot, Israel (Received 26 March 1992; revision received 22 May 1992; accepted 25 May 1992)
1.
Summary
Serum antibodies to the reverse transcriptase (ART) of human immunodeficiency virus 1 (HIV-1) were sequentially determined by ELISA in a group of 41 HIV-seropositive male homosexuals and 101 matched healthy controls, over 1 . 5 ~ years (mean follow-up 3.25 years). Mean A R T levels were significantly higher in the patient group as compared to the controls (195 ___ 75 vs. 75 ___ 45 absorbance (A) units; P 100 A units (mean A A 159.6 units) showed an attenuated decrease of CD4 ÷ (T helper) lymphocytes with a mean time of 42.5 months to reach a CD4 ÷ number of 400 cells/mm 3. In contrast, 25 matched seropositive patients whose A R T remained constant became CD4 ÷
Antibodies to reverse transcriptase in HIV infection and progression to AIDS A m i S c h a t t n e r a, R u t h M i l c h a n b, J o s e p h K a m i n c h i k b, Z i v a Y a v i n b a n d Z v i B e n t w i c h a aDivision of Medicine and R. Ben-Ari Institute of Clinical Immunology, Kaplan Hospital, Rehovot, Israel, and Hebrew University and Hadassah Medical School, Jerusalem Israel, and bBiotechnology General (Israel) Ltd., Rehovot, Israel (Received 26 March 1992; revision received 22 May 1992; accepted 25 May 1992)
1.
Summary
Serum antibodies to the reverse transcriptase (ART) of human immunodeficiency virus 1 (HIV-1) were sequentially determined by ELISA in a group of 41 HIV-seropositive male homosexuals and 101 matched healthy controls, over 1 . 5 ~ years (mean follow-up 3.25 years). Mean A R T levels were significantly higher in the patient group as compared to the controls (195 ___ 75 vs. 75 ___ 45 absorbance (A) units; P 100 A units (mean A A 159.6 units) showed an attenuated decrease of CD4 ÷ (T helper) lymphocytes with a mean time of 42.5 months to reach a CD4 ÷ number of 400 cells/mm 3. In contrast, 25 matched seropositive patients whose A R T remained constant became CD4 ÷
