Clinical Neurology and Neurosurgery 129 S1 (2015) S27–S29

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Clinical Neurology and Neurosurgery j o u r n a l h o m e p a g e : w w w. e l s ev i e r. c o m / l o c a t e / c l i n e u r o

Anterior knee pain caused by patellofemoral pain syndrome can be relieved by Botulinum toxin type A injection John Tzu-Ning Chena, Alice Chu-Wen Tangb, Shih-Cherng Linb, Simon Fuk-Tan Tangb,c,* a b c

Department of Medicine, Veterans General Hospital, Taipei, Taiwan Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, Taiwan School of Medicine, Chang Gung University, Taiwan

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abstract

Anterior knee pain Patellofemoral syndrome Botulinum toxin type A injection Isokinetic assessment

Objective: To investigate the therapeutic effects of Botulinum toxin type A (BTA) for anterior knee pain caused by patellofemoral pain syndrome (PFPS). Design: Prospective case control study for intervention. Setting: A tertiary hospital rehabilitation center. Participants: Twelve bilateral PFPS patients with anterior knee pain were recruited. The worse pain knee was selected for injection, and the counterpart was left untreated. Intervention: Injection of BTA to vastus lateralis (VL) muscle. Main Outcome Measures: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to assess pain, stiffness, and functional status of the knee, and CYBEX isokinetic dynamometer to assess isokinetic muscle force before and after BTA application to VL. Results: Remarkable improvement after receiving BTA injection was obtained not only in the questionnaire of WOMAC (p