Pathobiology of Aging & Age-related Diseases
ISSN: (Print) 2001-0001 (Online) Journal homepage: http://www.tandfonline.com/loi/zpba20
Animal models play a vital role in translational aging research Warren C. Ladiges To cite this article: Warren C. Ladiges (2015) Animal models play a vital role in translational aging research, Pathobiology of Aging & Age-related Diseases, 5:1, 27702, DOI: 10.3402/pba.v5.27702 To link to this article: http://dx.doi.org/10.3402/pba.v5.27702
© 2015 Warren C. Ladiges
Published online: 17 Mar 2015.
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Date: 18 May 2017, At: 05:20
Pathobiology of Aging & æ Age-related Diseases EDITORIAL
Animal models play a vital role in translational aging research nimal models provide a vital link for the translational progression of biomedical research from the bench to the clinic. However, animal models are not surrogates for human beings, but they rather simulate focused aspects of a disease or age-related condition. Therefore, any animal model must have defined boundaries to enable the integration of valid preclinical data for use in planning a clinical trial. It is important that these boundaries are continually defined and refined by identifying new model paradigms in standard laboratory animals such as the mouse, and also in novel animal species that may have overlapping boundaries with humans in a specific area. To promote the emergence of new animal model paradigms and new animal models in translational aging research, we are beginning a new feature called ‘‘Animal Model Brief.’’ This will be a short, one-page description of a novel observation in a relevant animal species, ranging from invertebrates, such as worms and flies, to standard laboratory rodents to domestic animals and nonhuman
A
primates. The first ‘‘Animal Model Brief’’ is being published concurrently with this editorial commentary. It is from the editor’s laboratory at the University of Washington in Seattle, Washington, and is an example of a novel observation in a genetically engineered mouse line that is of interest but was never published as a stand-alone paper. We think many research groups have numerous similar situations so that the ‘‘Animal Model Brief’’ will provide a venue for publishing unique findings in animals on a study that do not necessarily fit into a full-length scientific paper. We encourage submission of one-page descriptions of a potentially novel animal model or paradigm to be considered for publication in ‘‘Pathobiology of Aging and Age-Related Diseases’’ as an ‘‘Animal Model Brief.’’ Each brief will be peer reviewed and published as a onepage paper with no publication fee. Warren C. Ladiges University of Washington, Seattle
Pathobiology of Aging & Age-related Diseases 2015. # 2015 Warren C. Ladiges. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Citation: Pathobiology of Aging & Age-related Diseases 2015, 5: 27702 - http://dx.doi.org/10.3402/pba.v5.27702
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ISSN: (Print) 2001-0001 (Online) Journal homepage: http://www.tandfonline.com/loi/zpba20
Animal models play a vital role in translational aging research Warren C. Ladiges To cite this article: Warren C. Ladiges (2015) Animal models play a vital role in translational aging research, Pathobiology of Aging & Age-related Diseases, 5:1, 27702, DOI: 10.3402/pba.v5.27702 To link to this article: http://dx.doi.org/10.3402/pba.v5.27702
© 2015 Warren C. Ladiges
Published online: 17 Mar 2015.
Submit your article to this journal
Article views: 6
View related articles
View Crossmark data
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=zpba20 Download by: [80.82.77.83]
Date: 18 May 2017, At: 05:20
Pathobiology of Aging & æ Age-related Diseases EDITORIAL
Animal models play a vital role in translational aging research nimal models provide a vital link for the translational progression of biomedical research from the bench to the clinic. However, animal models are not surrogates for human beings, but they rather simulate focused aspects of a disease or age-related condition. Therefore, any animal model must have defined boundaries to enable the integration of valid preclinical data for use in planning a clinical trial. It is important that these boundaries are continually defined and refined by identifying new model paradigms in standard laboratory animals such as the mouse, and also in novel animal species that may have overlapping boundaries with humans in a specific area. To promote the emergence of new animal model paradigms and new animal models in translational aging research, we are beginning a new feature called ‘‘Animal Model Brief.’’ This will be a short, one-page description of a novel observation in a relevant animal species, ranging from invertebrates, such as worms and flies, to standard laboratory rodents to domestic animals and nonhuman
A
primates. The first ‘‘Animal Model Brief’’ is being published concurrently with this editorial commentary. It is from the editor’s laboratory at the University of Washington in Seattle, Washington, and is an example of a novel observation in a genetically engineered mouse line that is of interest but was never published as a stand-alone paper. We think many research groups have numerous similar situations so that the ‘‘Animal Model Brief’’ will provide a venue for publishing unique findings in animals on a study that do not necessarily fit into a full-length scientific paper. We encourage submission of one-page descriptions of a potentially novel animal model or paradigm to be considered for publication in ‘‘Pathobiology of Aging and Age-Related Diseases’’ as an ‘‘Animal Model Brief.’’ Each brief will be peer reviewed and published as a onepage paper with no publication fee. Warren C. Ladiges University of Washington, Seattle
Pathobiology of Aging & Age-related Diseases 2015. # 2015 Warren C. Ladiges. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Citation: Pathobiology of Aging & Age-related Diseases 2015, 5: 27702 - http://dx.doi.org/10.3402/pba.v5.27702
1
(page number not for citation purpose)
