0013-7227/92/1306-3113$03.00/O Endocrinology Copyright 0 1992 by The Endocrine

Angiotensin-II 17a-Hydroxylase Adrenocortical IAN

M. BIRD,

RONALD

Vol. Printed

Society

Acts via the Type 1 Receptor to Inhibit Cytochrome P450 Expression in Ovine Cells* R. MAGNESS,

J. IAN

MASON,

AND

WILLIAM

Cecil H. and Ida Green Center for Reproductive Biology Sciences (I.M.B., J.I.M., Obstetrics and Gynecology (I.M.B., R.R.M., J.I.M., W.E.R.), Pediatrics (R.R.M.), University of Texas Southwestern Medical Center, Dallas, Texas 75235

ABSTRACT.

In this study we have investigated the effect of angiotensin-II (A-II) on cortisol production and 17a-hydroxylase cytochrome P450 (P45Oi7,) expression in primary cultures of ovine adrenocortical cells and the A-II receptor subtypes that mediate these responses. While A-II alone had no stimulatory effect on cortisol secretion, it inhibited the cortisol response to ACTH (lo-@ M) in a dose-dependent manner (Ki,

Angiotensin-II acts via the type 1 receptor to inhibit 17 alpha-hydroxylase cytochrome P450 expression in ovine adrenocortical cells.

In this study we have investigated the effect of angiotensin-II (A-II) on cortisol production and 17 alpha-hydroxylase cytochrome P450 (P450(17 alpha)...
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