Bibliography of the current world literature This bibliography ts compiled by biotechnologists from the journals listed at the end of this publication. It is based on literature entered into our database between 1st October 1990 and 31st September 1991 (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue. • Papers considered by the reviewers to be of interest. O • Papers considered by the reviewers to be of outstanding interest. The number in square brackets following a selected paper, e.g. [7], refers to its number in the annotated references of the corresponding review.

Contents Analytical biotechnology gibozymes Applications of PCR DNA probes and automation Forensic applications Nucleic acid isolation and sequencing Biosensors FermentaUon monitonng

65 65 68 69 69 72 74

Carbohydrate analysis Isolationand analysis of proteins and peptides Assay systems Electrophoresis In vivo NMR and other non-invasive techniques Liquid chromatography Miscellaneous

75 75 76 78 79 80 80

Analytical biotechnology Ribozymes Review: (pp 3-7) FOgSTESAC, ALTMANS External Guide Sequences for an • RNA ~ e . Scwnce 1990, 249 783-786. [5]. GOODCrm.DJ, KOHUV ~ that Cleave an RNA • S e q u e n ~ f l ' o m Human Immunodeflciency Virus: the Effect o f Flanking Sequence o f Rate. Arab B/t~em Bft~abys1991, 284:386-391 [21]. GREENI~ ELLINGTONAD, SZOSTAKJW I n Vttnt~ G e n e t i c oO Analysls of the Teo~ab3nuwnaSelf-spllcins ingron. Nature 1991, 347.406-40@ 114]. P ~ AM. CECn T~ ~ e g e c o s n l t i o n o f RNA by o • Tertiary Interactions with Specific ~ 2'OH Groups. Nature 1991, 350628-631 [16]. RO~E~rSONDL JOYCEGF Selection i n V~l~oo f an RNA • • E n z y m e t h a t S l p t ~ t f l c m l l y C l e m ~ Single-stranded DN&. Nature 1990, 344-467-468 [4]. RUFF~RDE, STORMOGD, UHIENBECKOC Sequence OO ~uh"~B~ent8 Of t ] ~ ~lltmmeghct~d ]RNA ~ l f - d e m ~ l e l t a m ~ o n . B~..0emtary 1990, 29 1O695-10792 !171. S ~ X ~ SK, AC~mmV~NEJ. ~ C o r r t ~ Cleave a • Model Suh0tntte and Endogenous RNA/n V/t~ J B/o/Ox-ra 1990. 265.17106-17109. [26]. SIOUDM, DgUCAK. Pgtw~atinn of Human o o lmmunodeflclenc? ~ Type 1 i n ~ Expre~lon i n Emberg~ta ~ by • albozyme. Proc Natl Acad S~t U S A 1991, 88.7303-7307 [27]. TAYLORN, RO~I .U l ~ b o ~ r ~ - t ~ ' d ~ t ~ d C l ~ of • an HIV-1 G~g RNA: the ~ o f Non-tarl~ted Sequence* and Secondary Structore of Ribozyme Clem~ase Activity. Antto~nse Res Dev 1991,1 173-186

t221.

Applications of PCR Related review: Application of PCR to human gene detection (pp 8-11) AASENE, MEDRANOJF P C ! Amplification o f the Z I ~ and ~ Genes for Sex ldcntlflcatinn in Human*. Cattle, Sheep and Go~ts. B ~ o ~ 1990, 8.1279-1281 ABaOTr C, POVEYS DevelOlmaeot o f H u m Chromosome-Specific PCR Primers for Characterization o f Somatic Cell ~ d s . Genomms 1991, 9.73-77

AGUILARCORDOVAE, LI~BERMANMW ~ ~onal Sequencing o f PC]g-Amplified Genomic DN& [letter]. B/otec/mg/ues 1991, 11.62. ALEXANDERDC A Rapid Method for ] D ~ i e g n t i n i n s Clone Frequency i n Complex IP~pulatintm Using PCR and the Poisson Distribution. Nude~ A c ~ Res 1990, 18 7453-7454 AMENDOtAP~ HAENDELS, WEIERHU, pALIA'aCEmbiG. Trtmuqgene Integeation in ~ Fullicles and Peglphet~ Blood Cells M e . u t e r i by l.nvitro DNA Amplification and fluorescence insitu llybridlamtion. DNA Ce//B/o/1991, 10.311-317 A~ONVMOUS.Rehydratable Gels: • potential Ref=z~ce Standard Support for Eloctrophoceslns p t ~ m p l l f l e d DNA. B~ec/n,~/ogy 1990, 8.1288-1290 ANONYMOOS:h p l d Neonatal Dtagnmls o f Type l i b Yon W t i l d m m d Dlsemm Using the Pulymerme Chain Rem-'tion [letter]. B/ood 1991, 77 2539 ARNI~IMN, LI HH, Ctn X~ PC]g Amdysis o f DNA Sequences i n Single Cells - Sinsle Sperm Gene Mapping and Genetic Diseme Diagnosis. l e ~ t e w [l~lew]. Genomms 1990, 8:415-419. ASLANDISC, DE JONGPJ L i ~ t t i o n - ~ t Cloulng o f PCR Products (LIC-PC~). Ntw.lew Acids Res 1990, 18.6069-6074 ATREYACD, ATREYAPI~ PmONETP. Selection o f Deletion Mutants by Polymetmse Chain Reaction. B/~bem BiophysRes Comraun 1990, 173 1344-1346 AUc~ D, RETHM. Exon Trap Cloning: Using PCR to l~tpidly Detect and Clone Exons from Genomlc DNA l~'sql~ents. Nudetc Adds Res 1990, 18:6743 AURELIUSE, J O ~ N B, SKOLDENBERGB, STAIAND FORSGRENM Rapid DinwaosJs o f Herpes Simplex Encephalitis by Nested Pulymerwe Chain Re~-flon Assay o f Cerelzrospinal Fluid. Lancet 1991, 337:189-192 BALD~l& WARDDC. Insitu Hybridization Banding of Hum.tin Chromosomes with Alu- PCR Products - a Simultaneous Karyotype for Gene Mapping Studies. Genom/cs 1991, 9,770-774 BALNAVESME, NASlOUL~S, DAHLHHM, FORRESTS IMrtct PC~Rfrom CVS and Blood L y ~ t e s for Detection o f Cystic F l b r ~ I s and Duchenne Muscular Dystrophy Deletions. Nudem Acids Res 1991, 19 1155. BARIKS, GALINS~aMS M e l ~ p r i ~ e g Method o f ~ increttsed Template Concentration improves YieM. Btotechmques 1991, 10489-490

© Current Biology Ltd ISSN 0958-1669

BARNESTM Echolocation.. • PCR-Imsed StrateSY for k n ~ l y and napldly M a p p l ~ Tr,mslmCmm Insertion Site*. NtwJe/¢A¢~@Res 1990, 18:6741 BERNARDLE, BROOKSWILSONA]~ WOODS. llloL~tiotlo f DNA F ~ t s f r o m • Humm~ Cht'o~osomal Subrel#on by Alu l ~ t Differential Hybridizatinn. Genom/cs 1991, 9:241-246 BEXSESENMT, LUOQ, ROTBARTHA. BLASERMJ, ELLISONRT Detection o f lasterls-Monocytogcncs by Using the P u l y m e r a ~ ~ = ' ~ ~ o n . ~ Envgron Mtcmb/o/1990, 56 2930-2932 BICKNELLDC, MARKIED, SPUI~NI~ BODFC~R~gTF:ThC Human Chromosome Content i n I"][|umdmfilX Rodent Somatic Cell Hybrids Analyzed by a Screet~l~g Technique Using Alu P a l . Genomw~ 1991, 10.186-192. BLOCHW A Biochemical M o f the P o l y m e t ~ f~mtn Reaction. Btochera/stry 1991, 30.2735-2747 BORGI~SI~COLE~/1C, SCHUI2~DH. Pulymeg~e Rettct/on of Genes lqatxked by Short Noncontiguous Sequence Motlfl, Ana/Bwc~,m 1991, 192:449-452. BOP~ELLOF, K~UTERKS. Remcthm Site Pols~morphlsm in t h e Murlme Protam~ I n h i b i t o r ~ F~tlily is Delineated Using a Modification o f the Reactiott (PCR + 1). Nudetc Acsds Res1990, 18.5481-5487 BRISSON-NOEL~ AZNARC, CHUREAUC, NGUYENS, PIERRE C, BAWIOHM, BONETER, PIALOUXG, GICQUELB, GARP~GUEG. Digl~ools of Tuberculosis by DNA Amplification i n Clinical Practice Emdtmtion. Lancet 1991, 33&364-366 CHADBURNA, &THANE, WmCZOREKR, KNOWLESDM Detection and Characterization o f Human T-cell Lymphotrophic Virus Type 1 (HTLV. !) AMociated T-cell Neophtsms i n an HTLV1 Nonendemlc Region by Pulymerase Chain Re/tctlon. B/ood 1991, 772149-2430 CHANGAC, HO 'IF, CHANGNC' i n v l t r o Amplification by Polymerase ~ h . t . B e s ~ o n of a partial Gene Encoding the Thlrd-Subtype of Mpha-2 A d g e n e ~ c Receptor hi Hnmnns~ Bg0d3emB~hys Res Commun 1990, 172.817-823 CHEYROUA. GUYOMARC'HC, JA~ERANDp, BLOUINP Improved Detection of ItBV DNA b y PCR after Microwave Treatment of Serum. Nude~ Actda Res 1991, 19 4006

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Analytical biotechnolosy Applications of PCR CHItAJLANIV, RANGELN, UHLENS, WIKBERGJES' ldentlfi,-~tion o f an Additional Gone Belonsin8 to the Alpha2 Adrenergtc Receptor Family In the Hum.tin Genome by PCR. FEBS LeU 1991, 280.241-244 CHRISTENA~ MONTALBANOB Estinmtion o f Quantity o f Polymerase ~ Reaction Products by Ethidinm a r u m ~ . M p r u e e Plat* A ~ . B~-ecbn/ques 1990, 9310 CBaINOGD, METCHE'rrEKC, TESSMANJW, HEARSTJE, ISAACS ST: POst-PCR Stt~llll~tion: a Method to Control Carryo~-r Contamination for t h e Pulymernse Re•¢tion. Nuc./e/cAcgdsRes 1991, 19"99-107 CLAYTM, BIDWELLJL, HOWARDMR. BRADLEYBA. P O f flngetprtntin8 for Selection o f HI.A Matched Unrelated Marrow Donors. Lancet 1991, 337 1049-1051. CONERW ETA~ P u l y m ~ Chain Reaction Decontamination: the Wipe Test [letter]. Lancet 1990, 336~686 CORNALLRJ, AWMANTJ, HEARNECM, TODDJ ~ The Generation o f a Library of PCR-Analyzed MlcrnsateiliteVariants for Genetic Mapping of t i ~ Mouse Genome. Genom/c~1991, 10:874-881 D'AQUnART, BECHTELLJ, VIDELERJA, ERONJ~, GORCZYCAp, K~ta~ Jc: M n i m i z ~ ~ i l t l v i W a n d Spedflelty of ~ by iSre-ampli]lcation Heating. Nucleic Acids Re* 1991, 19:3749. DAUGI~RTYBL, DEMARTINOJA, LAWbIF, KAWKADW, SINGERlI, MARKGE: P O ~ C h a ~ geaction l ~ t l i t a t e * the CloulnS, CDR- G r a t i n g , ami Rapid E x p r e ~ i n n of • Murine M o n o d o t m l Antibody Directed ,t=~,mt the CD18 Component of Leukogy~ IBtelptns. Nucle~AcglsRes1991, 19.2471-2476. DAVISVS, BOYLEJ~ A d • p t ~ the Poly~teg•~e Ch~Ltl Re*orion to a Double-Strunded RNA Genome. Anal Btocbem 1990, 18930-34 DILLONpJ, ROSENCA. A 8.tpid Method for t h e Commrucflon o f Synthetic Ge~e* Usin8 the Pulymerm~ Oh.lit Reaction. Bmtec.hntques 1990, 9298 DOCIG-IOB~WORN1CZAK8, DWORN]CZAKB, BROMMELKAMP L BULLESJ, HORSTJ, BOCKF~WW, Non-botoplc Detection o f S i n # e Strand Con/ormm~on ~ulymorphtsm (i~t-SSOD - • Rapid and Sensiti~e Techlflque in D i • S n o s ~ o f P l ~ o r i ~ Nuc2emAc/d.s Re. 1991,19.2500 DON RH, COX PT, WAn,mmGrrr BJ, B ~ K, MAamCKJS 'Touchdown' ~ t o Circumvent Spurious Re* 1991,19"4008 EHPENPPEISJ, I-I~J~RSM, J ~ B, pFORDTM, SCHWINGER E, VO~BE~.~l i P . / ~ of • D y s t r o p h i n Gone Deletion by Amplilication o f Messenger RNA Isolated from DMD Myotubes C u l ~ invitro. Genom#.s 1991, 10:551-557 EIKENHG, ODIANDE, BOMANH, SI~XIKVALEL, ENGEBRWI~EN • LF,,'~OLOJ Appli~ationofNaturuland Amplification C.r~_*_,~_Re*trtction Sites for the Dial~tm~ o f ~ Momtions. Nudem Acu/s Res 1991, 19:1427-1430. [13]. ERUCHHA. GELFANDD, SNEAKYJJ: Rg~ent Ad~m~ces i n the Pulymerle Chain Rructton [In = " " _ ' h l [review]. Sdence 1991, 252:1643-1651 ESTrVlLLX ETAL- Prenatal Dlagm~is o f Cystic Fiiwnsis by Multiplex PC~ o f Mutation a n d M i c r c ~ t e m t e Allele* [letter]. Lancet 1991, 335458. bEY MF, TOBLER& & ~ e ~ m e n t o f DNA l ~ e r p r i n t l n g am • Method fog Validstl~8 the I d e n t i t y o f Cancer Cell Line* Maintained i n Long-Term Culture. Nucde~ Act,s Re. 1991, 19.3464 FLAEGSTADT, SUNDSFJORDA, AgrHURRR. PEDERSENM, TRAAVmT, SUBRAMAN~S. Amplification and Sequencing o f the Contrul R e # o R s o f BK mad JC Virus from Human Urine by p o l y m e r m e O ~ i n Rcagtion. t~ro/o~, 1991, 180:553-560 FRrlXJD, GREASERML. WOLFFJA. A Novel 3' Extetmion Technique Using Random Primers i n I~IA-IN~R. Nude~ A6/dsRe. 1991, 19 3747 FUJ1NAGAY, SI'ed~,DAM, OKAZAW^K, FUKOSH1MAM, KATO1, F 0 ~ C ~ K SimulUmeons Deteotlon and Typing o f Gel~tei Hnman P~piliom~vitt~ DNA Using the Polymeg•se Chain Reaction. J Gen Viro11991, 72 1039-1044 FlinG MC, FtrNGKY-M, POt Amplification o f MRNA IMrectly from a Crude Ceil L y ~ t e Pcepored by Thefmophflic Prute*se Digestion. Nudem Acids Res 1991,19:4300. FUQUASAW,FTITJ3ERALDSD, MCGUIREWL A Simple P u l ~ m e l ~ Citstn ReaJctioll Method for Detection trod Cloming of I.ow-Abundlmce Trmmcripts. Bu~echnwues 1990, 9-206 G A ~ Y A. PSOCKOeDJ- Detection o f Single4mse Mutations by Reaction o f DNA Heter¢~uplexes with • water-soluble ~ l ! m l d e Followed by Prtme~r ~ i o n : Application to Products from

the Polymer•tin Chain Reaction. Nucletc Actds Res 1990, 1&3933-3939 GARSONT ETAL l ~ n h ~ c e d Detectiofl by ~ o f HCY RNA [letter]. Lancet 1990, 336.878 GO--AVID N, GATI"IRA, NEUWIRTHH Aotommted Direct Seqoencing of Polymetnse Chain Reaction- Amplified Fragments o f the H,tm*n H a . r u Geoe. Anal Bto~e'm 1990, 191.359-364 GRmLDM, MARGOUSFL Use o f R e v e r ~ Transcripta~e Polymegue Chain Reaction to Monitor Expression o f intruule*s Genes. BmteChn~/ue~ 1990, 9:262 HA~ L, SUBBARAOSM, HARDERT, LESSB, BAP.PETrT Detection o f Phocid Distemper Virus RNA In Seal Tissues U s l i ~ Slot llylwldization and the PulymeNme Chain Reaction Amplification A ~ a y - Gettetic Evidence that the virtm is Distinct from Canine Dtatetaper Virns. f Gen Vwo/1991, "72.825-832 HANISCI~ BERTINTIC Identification of an i o s u i l n Receptor Exon 8 N d Polymorphlsm Using the laoly~mr~Je C h o i r l ~ l ~ t i o n . Nuc./emAC~[~Res 1990, 18;5923. HE WW, FISCHERLM, SUNSQ, BB.HARTZDL, ZHU XP, YOUNG CYF, KELmYDB, TINDALLDJ Molecular Cloning o f

A~lruSen ~ c e p t o ~ Uom m,~-ment s p ~ e * with • P o ~ Chal~ Reaction T e d m i q u e - C o m p l e t e CDNA Sequence of the Mouse A n d r o g e n Receptor a n d Isolation o f A n d r o g e n Receptoe CDNA Probes from Dog, Gulnca C l m ~ d FrOg. Bmclxom Bmphys Res COramun 1990, 1"/1:697-704. HEr~O K, FIEmEYM- Quanmttve ~ the D e t e r m l u t i o n o f Template Copy Numbers by Tempeg•ture tT~r•dlent Gel Electrophore*ls (TGGE). Nuc/e~ Actds Res 1990, 18.6773 HERIZI~ S, KOENENM A Coener~ and Rapid mutalgenesis Method UsL~g P o l y m e r ~ C h a ~ Resetlon. Gone 1990, 91 143-147 HERMANGE. BERRYM, M ~ E, CRMGIW, LEvYER. The Coostruot/on o f H " m a n SOt~ttiC Hy~'lds Cofltaining PogtJons o f the Mouse XChromo@otae and Their use to Generate DNA Vis Interspersed gepetitive Seqoence P o M Chain Reaction. Genomw.s1991, 10.961-970. HUANGP, TEMIZERD, QUERTERMOUST Polymermm ~hmin Re•orion Cloltting o f L-Type Ctdcium ~ * t s n e l Sequences from the Heart and the Bgain. FEBS Le~t 1990, 274:207-213. HUGIF~T, GOLDMANJM" l m ~ Results with PCR for O~L [letterl. Lancet 1990, 336812 HUGHESTP, MORGANGJ, MARTIATP, GOLDMANJM Detection o f Re*ldual Leukemia after Bone Marrow Tnmsplant for Chronic Myeluld leukemia: Role o f P o ~ Chain Reaction i n Prcdictin~ Relapse. B/ood 1991, 7%874-878 HUNGT, MAKK, FONGK. A Specificity t ~ n h . ~ , ~ r f o r Pulymet'ase Chain Reaction. Nucle~ Acids Res 1990, 18 4953. ISAACSST, "IY~SMANJW, METCHETTEKC, HEARSTJE, CIMINO GI~. POSt-PCR Stegtiizatinn, Deveiolmaent and Application to an m v D t ~ n n s t i c Assay. Nuc/~ Acu~sRe. 1991, 19:109-116 JANSENR, I£1X~YF~. Disruption of Plume Dortn 8 During I ~ g Amplification and Cloning o f Hetoroz~Bons Target Seqoences. Nude~ Acids Re. 1990, 18.5153-5156 JINNO Y, YOSHIURAK, NIW.AWAN Use of IMogalen as ~ h e t " o f Cot~ttmnitmted DNA in PCR. NudeicAcidsRes 1990, 18.6739. JONES DH. HOWARDBH. A Rapid Method fog ltecmmbinatioo and Site-Specific Mutagene*ls by PIscing HOmologous Ends o n DNA Using P o ~ ~ Reactinn. Bu~.hntques 1991, 10.62~6. JONES ST, BENDIGMM Rapid PCR-ClotlI~ o f FllliLen~lh Mouse l m m u n o g l o b u l i n Variable Restooa. Bggedmo/0g), 1991, 9.88-89 JOSHIAK. BAICHWALV, A~S GFL I ~ l d Pulymet'ase ~ h . i ~ Reaction Amplification Using intact Cells. Bu~ecbn~ques 1991, 1042 KAL~ZS, REIDKBM. A Novel Rapid Method for Detectioo o f ~ P~fodu~ts. Nude~ Ac/ds Re. 1991, 19.4012 H, LEEDI~ HSU KC, SHARPGC, HOFFMANRW, Solid-Phatm Dire~t DNA Sequencing o f AlleieSpecific P o l y m e r ~ e Clmin Reacttoo-Amplified HI~-DR Gemm. B~ect2miques 1991, 10.30 KAUFMANDL, EVAN~GA: Restriction Endonuclense Clear.SO at the Termini o f PCR Products. Bmtec.hn/ques 1990, 9 304-306 KELLOGGDE, SNB~SKY.[J,KWOKS Quantitation o f HIV1~ DNA Relative to Celiular DNA by the Chain Reactioo. Aria/BmoE~em1990, 189.202-20~

KEMPDJ, CHURCH~LMJ, SMITHDB, BIGGSBA, FOOTESJ, PETERSONMG, SAMAR~N, DEACONNJ, DOHERTYK Simplified Colorimettic A_oalysls o f Pulymerase Chain Rcections -Ik-tection o f m v Sequences in AIDS Patients. Gene 1990, 94.223-228 KOVARH, JUG G, AUERH, SKERNT, BIASSD: Two D/menslonsl SintOe-strind Conformation Polymorphtsm Analysis: a tmeful Tool for the Detection o f Mutations in Lottlg DNA FrJqlment~. Nu~le~ Acids Re~ 1991, 19 3507-3510 KmSTIANSENB-E, ASKE, JENK~SA. FER~ERC, ~ M P, SKOLDO- Rapid Di.ctSnosl~ o f Meol.n~o~.atl Menin#ti~ by P o ~ Chain Reaction. Lancet 1991, 337,1568 KROPP GL, FUCHAROENS, EMBURYSH. Asymmetgic•liy Primed Selective Ampllfication/TemporJtore Shift Fluorescence P u l y m e r ~ e Chain Reaction to Detect the Hemoglobin Constant Spring Mutatioo. B/ood 1991, 78.26-29. KWIATKOWSKITJ JR, ZOGHBIHY, LEDBETTERS~ ELLISON KA, CHINAULTAC Rapid Identification o f Yeast Artificial Chromo~mme Clone. by Matrix I ~ u l i n g •nd ~ Lysatc PC-JL Nude~ Ac/ds Re. 1990, 18.7191 LACEYSF, SUZUTAN1T, POWELLKL, PURIFOYDJM, HONE~ RW, A ~ y s l s o f Mutations ht the Thymidine KImu,e Genes o f Druff XesisUmt Varicella-Ze*ter Virus P o p u l a t i o m URnS the P o t y m e r ~ e CZ~tn Re•~lon. J Get: Vffo11991, 72:623-630 LAILOZMRA.MCVEYJH, PATI'I~ONJK, TUDDENHAMEGD llsemophlila-A Dinlptnsls by Analysis o f a ~ k D i n u d e o t i t i e R e p o t Wlthin the Flmtor-viII Ge~B. Lancet 1991, 335:207-211. IANDGRAF& RECKMANNB, PB~-,OUDA: Qmmtliative / m a y s l s o f ~ohrmemse Chein a e s c t l o n (PCR) Products Us/rig Prhmers Labeled with Biotin and a l q u o r e ~ e n t Dye. AnalBt~bem 1991, 193:231-235 IANGEVELDSA, DOPEJM, MEMELINKJ, DERKSAFLM, VANDERV~GTCIM, ASJESCJ, BOLJF: Id~atiflcation o f Potyviruses Usln8 the P O ~ Reaction with Degenerme Primers. J Gen Vwo/ 1991, 72:1531-1541 LASMOLESF, MB4VIELLES, COHENR. GULIANAJM, DELEHAYE MC, SECONDN, ~ C, MILHAUDG, MOUIflffTAR MS PCR Amplification o f CGRP-II Metmenser RNA - Variable Ex]pr~minn In Tumoral mKl Non.Tumogul ~UmOn T]h~t'oid. FF-J~ Left 1990, 27"/243-246 LAVEDANC, DUROSC, SAVOYD, LEBLONDS, BAILLYJ, KORNELUKR. JUNIENC' ~ H a p i o t y p ~ by Double Dlge*tion o f l~CR-Amplified Crrutine Kin.so ( e l B a ) . Application to Myotonlc Dystrophy Dtsllnosis. Genomw.s1990, 8:739-740 LAWLERM, HUMPm~ESP, McCANNSl~ Evalu•tion of Mixed Chimerlsm by in Vitro Amplification o f D i n u d e o t i d e Repeat Sequences Using the P u l y m e r ~ e ~'.ain Reaction, B/o~d 1991, "/'72504-2514 LEDBETTERS~ GARCIAHERASJ, LEDBETFERDH PCRIG~'FotyI~ o f l t t ~ = ~ Om'omom)m~ i n Somatic Cell ~/m'M~. aenom~s 1990, 8.614-622 LPERRREJ-J £TAL PCR Testing i n lllV-1 ,~'~t~te~ttive HaemophtUa petter]. Lancet 1990, 336 13s6 l~w AM, KELLYJ. Capture o f Cltromogomal DNA by Anti-Eli.tone Antibodle* for PCIL Nuc/e~ AcidsRe. 1991, 19:3459 la H, CLq X, ARNVmIMN ~ t ~ Prlmegs from Completed P o ~ ~*tn P~'tions with F,xonucleme VII. N ~ t ~ ~ Res 199], 19'3139-3141. LtNCHAOS, BRENNERDG, COHENSN. Rapid 2-Stage Pulymersse Chain Reaction Amplifie*tiott o f Chromtmomad DNA Selpoents i n Lytmtes Made frommM ~ l l • ~ Cul~ Attached to Mlcrocaf~er Beads. Gone 1990, 93.293-256 IRONT, HA~ OA: Nonradimmttvt l a b e l i n 8 o f Probe

with Di~oxJ~t~ by e'ul,~merm~Omm R~mctioo. Aria/B/oc0em 1990, 188.335-337 LIZARDIPM, KRAMERFR: Exllmmential Amplification o f Nucleic Acids: New D i a s n n s t i ~ Using DNA P u l y ~ e r a s ~ and i ~ A Replicases. Trends B/otechno/1991, 9 53-58 [/D Y MD, PATELP, NEWTONCI~ MARKHAMAF, FLEMINGKA. * WAINSCOATJS: D i r e ~ H~piotype Determlnttion by Double ARMS: Spedfldty, S¢~mitivity and Genetic Appli~ttiolu. Nuclew Actds Re. 1991, 19.3561-3567, [10]. LONGOMC, BERN~GERMS, ~ JL Use o f Uracil • • DNA Glycosylase to Control Carry.Over Contamination in Polymerase Chain Rruction. Gone 1990, 93 125-128. [321. MADSENH ETA/.: PCR for Fetal Platelet HPA-1 Alioantl[len Typing [h~ter]. Lancet 1991, 337493 MAURERJ, JANSSENJ~G, TI-HELE, VANDENDERENJ, LUDWIG W-D, AYI~MmU, HERq2XB, FONATSCHC, HARBOTF J, REWERA, REHMH, HOEIZERD, BARTRAMCK

Analytical biotechnology Applications of PCR Detection of Chimeric BCR-ABLGenes i n Acute Lymphobisstic LeukemLa by the Pulymerase Oa•ln Reaction. Lancet 1991, 33"/:1055-1057. MERCIERB, GAUCHERC, FEUGE/6O, MAZUR~RC: Direct l a i r fgom Whole Blood, Without DNA Extraction. Nuc./e~ Actds Res 1990, 18:5908. M1YAMU~K ETAh: Prediction of Clinical ReLalme after BMT by PCR for Phlisdelphin-lmeitive ALL

[letted. Lancet 199o, 336:89o. MOCHAm.AH, MOCHARIAR, HOtmSME: Coupled Reverse Tramtctqption-Polymerase Chain Remction (RT- PC~) as • Sensitive and Pmpid Method for Isozyme Genotypin8. Gene 1990, 93:271-275. MOmGOm~ P~ D ~ MJ: A n a l ~ i s o f Cytokine Gene Expression Durin 8 Fetal Thymlc OntoBeny Using the Polymer~se OAain R e ~ t i o n . f Immunol 1991, 147:554-560. MOORESS, SARGEANTI~ KINGTJ, MA~nCKJS, GEORGESM, HE'IT~LDJS:The C o n a e r ~ t i o n o f Dinucleotide MiCgO~[4EIt~lJJ~ A m o ~ l~L~mmallan ~,~ltlOIl~tIH~ Allows the use o f Heteroiogous PCR Primer Pairs i n Closely l e l a t e d Species. Genom~.s 1991, 10:654-660. MURPHYLD, ~ CE, RODICKJB, FOJOAT, BATESSE: Use o f the Pulymenme Chain Reaction i n the Qmmtimtion o f Mdr-I G e n t Expcemflon. B/ochemt3try 1990, 29:10351-10356. MUTI~RGL PO~N10 RJ: Molecular Dinlplosis o f Sex C~romosome Aneupioidy Using Qtmntitative PCIL Nuc/.e~ Ac/.dsRes 1991, 19:4203--4207. MYERSTW, GELEANDDH: l[&q~q'~teT ~ p t i n n suntd • DNA A ~ p l i ~ ¢ • t i o n b y • Thermus Thermophilus DNA Polymer•se. B ~ i s ~ y 1991, 30:.7661-7666.

I2Sl.

NEALEGAM,MEN~GtmZJ, Krrcvm~Gv~NGIL FrrzGe~LD TJ, KoEm~x M, M m ~ J JR, Goom~ RM: Detectlon Of Mlnlm~It l e s l d u • l ~ i n T-cell Acute Lymphobisstic Leukemia Using Polymenme Chain Rcaction Predicts i m p e n d i n g ReLapse. 1991, 78:739-747. NEGRINRS, BIMI~ KG: The use o f the Polymgneme Ohain Reaction for the Detection o f Mindmal MallBtmm [edltofLal]. B/00d 1991, 78:25%258. NEGRINRS, KIEMHP, SCHMIDT-WOLFIGH, BLOMEKG, CLEARY ML Use o f the Pulynmes~ Chain Rcactlon Marttlm to Monitor the Effectivenees o f Ex Vlvo Tumor Cell P u r g e . B/o~d 1991, 7 7 . 6 ~ . NOONANKE, BECI C, HOtZMAYERTA, CHINJE, WONDER JS, A ~ m l m I1. C.ma~ AF, Wn~a~ CI. G~'vrm B, VON HOFFDD, RONINSONIB: Qmmtltiv~ Analysis o f ~ (multidru 8 Resistance) Gene Kxprmminn i n H,,m.n Tumors by Pulymcrese Chain Reaction. Proc Naa Acad Sa USA 1990, 87:7160-7164. NUNESV, CHIH~NM, LENCHN, RAMSAYM, ES'IWILLX: PCR Detection o f t h e PKM.19/Serfl RFLP (D~$23), • marker Closely r i . ~ , . d to the Cystic Fibrosis Mutation. Nuc2e/c Adds Res 1990,18:4957. Ou CY, MOO~EJI. SCHOCHETMANG: Use o f UV Irradiation to Reduce False P o s i t i v i ~ in Pulymenme Chain leaction. B/otechniques 1991, 10:442. OZAWAT, TANAKAM, IKEBES, OHNOK, KONDOT, MIZUNO Y: Quantimtiv~ Detegm|nstion o f Deleted Mltochondrisl DNA Reistive to Normal DNA i n P ~ k l m o n b m Strinmm by • Kinetic Analysis. B i ~ e m B~/~a~s Res Commun 1990, 1"/2:483-489. PANACClOM, LEWA: PCR Based Dhql~osis i n the o f 8% ( v / v ) Blood. Nu6/e~ Ac/ds R~ 1991, 19:1151. PARLORJD, RABENOVITCHPS, BURMERGC: Taggeted Gene WaUdnB Pulymerme C h * , - Reaction. Nude/c A c ~ Res 1991, 19:3055-3060. PERmUS, GmalA~ G: Site-Specific Mutagenesis Using Asymmetric Polymormm Clmln Re~mtlon and • Single Mutant Primer. Nuc/e/c Ac/ds Res 1990, 18:7433-743& PETEF~IENMB, SCh~2~L~ BINKERTF, TRANEBJAERGI~ Mm/~kSEN M, COLLateSF& ECONOMOUEP, ANTONARAK~ SE: Use o f Shogt Sequence Repest DNA Pulymorphisms after ~ Ampl/flcation to Detect the lhurental Origin of t h e Add/tional Chromomome 21 In Down Syltdrome. Am J Hum Genet 1991, 48.65-71. PFEIFERGP, I~GGSAD: Chromatin ~ c e * Between Active and Inactive X.-Chromo~omes Revealed by Genomic Foot'printing o f Permeabllized Cells Using DNAse-I mad lJgation-Medinted PCR. Genes Dev 1991, 5:1102-1113. PFEWERGP, STEIGERWALDSD, HANSENRS, GAgTLERSM, PdGGS AI~ P o ~ Chain Reaction-Mded Gtmomic CpG Island - MethyLation Pattertm SurlieSt Clonal Inheritance, CpG Site Autonomy, and an Explanation o f Activity State Stability. Proc Nail Acad Sct USA 1990, 87:8252-8256.

POGG|V, TOWNM, F ~ NS, LtYLZATIO12 Identification o f t S i ~ e Base Ch~,n~,e in • New Htlmon Mutant Glucme-6-Phoepimte D e h y ~ Gene by po~-K~aln. Reaction Amplification o f the Entire Codln~ Region from Genomlc DNA. BioO~m J 1990, 271:157-160. POgI'ERKR, POLOSl, IK)NGG~', MERRITFS~, OPRANDYJJ: A ILapld Membrane-lmsed Viral RNA IsoLation Method fog the Pulymerese Chain Reaction. NucJef~AcidsRes 1991, 19:4011. RAINEPaI, MORONIC, SENNHP: i m p r o v e d Emclency for Sin#e-sided PCR by Creating • Reusable Pool of Flest-strand CDNA Coupled t o a Sulld Phase. Nuc.let~ActdsRes 1991, 19:4010. ~ E N S, TtMMSP: Detection of ChLamydLa-Pslttucl Using DNA Probes and t h e Pulymefme t~ha|n Reaction. FEMSM/crobto/Lett 1991, 77:169-173. REYr~LDSP.. S ~ U G H G, BLAI~E: Analysis o f Genetic Mm'kers i n l ~ r e n s i c DNA Smuples Using the

l ' u l ~ - r a s e c l u a n mmction [aeview]. Aria/O~m 1991, 63:2-15. RICHj~, ~ DK: A Single O l l s o n u d e n t i d e can be ~ tO Rapidly IsoLate DNA Sequences FIm,mklnet • Ttmaspooon Tn5 Insertion by the Potymeesse Chain Rem'tlon. Nuc_/e~Ac/ds Re~ 1990, 18.6673-6676. ROBERTSONNI. FRENCHI~ GRAYSM: Use o f G g o u p - ~ l l t C Pttmees and the P o l y m e r u e Chain l c a c t i o n for the Detection a n d Identification o f Lutem,iruses. J Gen Vtro11991, 72:1473-1477. RODUB, CHI~STIANC, SNYDERRC, RAYP~ MILLERDM: Simplified I~lI-Batmd Detection and Typin8 Stl~t~'l~ fog Human ] P I p m ~ U tlll~ina, • SllmlgleOllgonuclentide Primer Set. B/otechn/ques 1991, 10:632. ROHANRM. ~ D, FRETSWI: Direct Sequencing o f PCRamplified J u n c t i o n Fragments from Tandemly Repeated T ~ e s . Nucde/cAc/ds Re* 1990, 18.6089-6095 R~ICKI EP, HUGHESFL Detection and Typing o f Msise Stt"esk Virus and Other Distantly ReLated Gemiulviruses o f Gresses by P u l y m e n ~ Chain Re•ctlon Amplification o f • Conserved Sequence. J Gen Viro11990, 71:2519-2526. SAGNERG, RUGERR. KESSLERC: Rapid Filter Assay for the Detection o f DNA Polymerese Activity Direct Identification o f the Gene fog the DNA Pulymorme from Thermus-Aquaticus. Gene 1991, 97:119-123. SAPERSTEINDA. NICI~RSONJM: l~t~trictioll Fragment

Lens~h ~ob,m o r p h ~ m mudysis Usin~ Coupled to Restriction Digesta. B/otechn/.qu~ 1991, 10:488-489. SARK~FH, CRISSMANJD: Detectinn o f Humlm Papilloma DNA Sequences by Pulymerase Chain Ihmction. B/otec2m/ques 1990, 9:180. SARKARG, KAPEk'~XRS, SOMMERSS: ~ d e Dmmmtically Imptm~m the spectfidty o f PCR. Nude~ AcM.~Res 1990, 18:7465. SAm~ G, SOM~mRSS: Hapiotyping by Double PCR Ampllficmlon o f Spe¢~c Alleles. B/otechnM.es 1991, 10:436. SAmara G, SOWmRSS: Pamuneters Affectin8 Swceptibility o f POt Contamination to UV Inactivation. B/otedmMu~ 1991, 10:590. SAWAD, HOLUMANRE: PCR to Detect T o x o p l ~ m a [~]. Lancet 1990, 336:1325. SCHWAgIXEl, SHEVrSOVSP, KtJCVaNSKIAP, KOVALEVYP, pLIJTAIDVOV, BERLINYA:Apprtmch to Identification o f t Point Mutation in Aim B100 Gene by Me~n~ o f • l~l-medLated Site-directed Mutasenesis. Nuc/e/c Ac/ds Res 1991, 19:3752. SEIBELP, DEGOULF, RO/~RO N, MARSACC, KADENBACHB: Identification o f Point Mumtiotm by Mlspairin8 PC]t ms Exemplified i n Merrf M . B ~ BiqM~ Res Commun 1990, 173:561-565. SHAFFERAL,WOJNARW, NELSONW: Amplification, Detection, and Autommted Sequencing o f ~ n interleukin-2 Messenger-RNA by Thermus-h4uaticu• DNA Poiymerme Reverse Transcription and Polymerese ~ h * i n Reaction. Aria/B/0c~om 1990, 190:292-296. SHANKARP, ~ T H N, MOHANKl~ PRASADK, BEHAPJ SI-IRINq~AS,/fflUJAG ~ l ~ p l d Disgntmis o f Tuberculous M e ~ i n ~ t i s by Polymerase Otain Reaction. Lancet 1991, 337:5-6. SHUIDINERAR, NmULAA, ROTHJ: RNA TempLate-Specific Pulymerase Chain Reaction (RS-PC~) - • Novel Strategy to Reduce Dramatically False Positives. Gene 1990, 91:139-142. SLMARDLIL GINGRASF, LABUDA D: Direct Atmly~ls o f Amnintic Fluid Cells by Multiplex PCR Pror/des ILapid Prenatal Diasnosis for Duchenne Muscular Dystrophy. Nucle~ Acids Res 1991, 19:2501.

S~GERSAMJ, GRANTM, LEBONJM, OKUYAMAK. CHAPMAN V, MONKM, R1GGSAD: Use of a l t l m l l - P u l y m m Chain Re•orion Assay to Study DNA MethyLatinn in the Pgk-1 CPG Island of Mouse Embryoo at the Time o f X-Chromosome Inactivation. Mo/Ce// BI~X/1990, 10:4967-4989. SKOGERBOEKJ, ~EST SF, MURILLOMD, TAW.IF:PCR Dot Blots - [Agge Signal Diffegences Between Sense and Anti-Sense Probes. B ~ h n ~ / u a s 1990, 9:154 SMITHB, SELB¥P, SOUTHGATEJ, P1TTMANK, BRADLEYC, BLAIR oO GE: Detection of Melanoma Cells i n Pzr/pheral Blood b y Means o f R ~ v ¢ i ~ Transcriptase and Pulymegase Chain Re•ction. Lancet 1991, 338.'1227-1229. [27]. SORSCHEREJ, HUANGZ: Disgnosis o f Genetic Disease by Primer-specified RestriOJon Map Modlacation, with Application to Cystic Fibrosis and Retinitis Pigmentosa. Lancet 1991, 337:111%1118. SUN~RIFJ, LEE T-H, BROWNLEERG, BUSCHMP: h p l d Simultaneotm Detection o f Multiple

DNA Sequences Using the Pulymora~ Chain acection a n d CapilLary DNA ChromatoWapby. B/ood 1991, 7"/:879-886. S0ZU~0Y, SEKIY^T, HAYASmK: Allele-Specific Polym~ Chain geuction - • Method for Amplification and Sequence Determination of s Single Component A m o n s • Mixtore of Sequence Variants. Ana/B/ocbem 1991, 192:82-84. TANGUAYRL PFEIFERGP, I~GGSAD: PClt-•lded DN•sel

Footprtntin$ of Sinsle Copy Gene Sequences in Pegtaesbllized Cells. NucJe/c .4c/ds Res 1990, 18:5902. THEUNES, FUNGJ, TODDS, SAKAGUO-nAY, NAYLORSL PCR Prinlets for Human Cht'o~oeomes - lhtt~-.nts for the lhtpid Analysis o f Somatic Cell Hybrids. Genom/cs 1991, 9:511-516. TORELUG, ~ I~ Lt*Pl M, SEtLEmL FE~m S, NARNIF, MARIANObiT, FEDEmCOM, CRCCHERt/~NEIMI. BENDINELLIM, MONTAGNAN1G, MONTORSI M, ARTUSIT: l-/.m,,n H ~ i n ]B[umtn Lymphomss: Identlflattion o f Specific i n

nedsMn's Lymphomm by P u l ~ e r u c Chain Reaction. B/o~d1991, 77:2251-2258. TRA1NORKJ, BRISCOMJ, WANJH, NEOHS, GRISTS, MORLEYAA: Gqme Rearrangement i n B-Lymphoprolifesative and T-LymphoprollforathFe ~ Detected by the P o l y t a ~ O m / n l e • c t i o n . B/ood 1991, 78:192-196. VANLOI-VOI~NM, VERBEEKS, SCHEUENB, WIENTJENSE, VANDERGULDENH, BERNSPc ldentlAc•tion o f Cooperating Oncogenes in Famu-myc Transgenic Mice by ~ Tagging. C.e//1991, 65:737-752. VONNtTdZSACKERF, LABEITS, KOCHH ~ OEHKERTW, GEROK W, BLUMHE: A Simple and ~ t p l d Method for the D~teL~Jon o f i ~ A in Formalin.Filed, ~ Embedded Tissues by PCR Amplincation. B~chem Biopbys Res Commun 1991,174:176-180. WAKEFIELDAE, GU1VER1. MILLERRF, HOPK/NJM: DNA Amplification o n induced Sputum Samples for Diagnosis Of/hwumorys~s C a r t n a Pneumonhu Lancet 1991, 337:1378. WARD~ OI/VIEPdNF, NGJ, RODERJC: Detection of ~-th.I---,emLa Using an ArtlflcLai.reateiction Fessment Length Polymorphism C,enemted by the Pulymerme Chain Rcaction. Nuc./e~ Acids Res 1991,19:959. WELSHJ, MCCLELLANDM: Flngegprhtfln8 Ggttomes Using PCR with Arbitrary Primers. Nude~ Ac/ds Res 1990, 18:7213--7218. WELSHJ, MCCLELLANOM: Genoml¢ Fingerprints Produced b y PCR with Consensus TRNA Gene Primers. Nuc/e~ Ac/ds Re~ 1991, 19:861-866. WELSHJ, PETERSENC, McCLELLANDM: Polylnorphisll~ Generated by Arbitrarily Primed ~ i n the Mouse: Application to Strain ldenttllc•tinn and Genetic Mapping. Nude/¢ Ac/ds Res 1991, 19:303-306. WENHAMPR ERA/.: Apolipoprotetn E G e n o t y p t t ~ by One-stage PCR [letteg]. Lancet 1991, 337:1158. WEPaX~SK. DELEGOUE, SOENTOROPS, NOTERMANSS: Successful A p p r o ~ h for Detection o f Low Numbers o f Enterotoxigenic Escherichia-CoU in Minced Meat by Us/rig the P u l y m ~ Chain R~tction. AJ~0/EnvironM~robio11991, 57:1914-1919. WILDEJ, YOLI~NR. WILLOUGI~YP~ EH)ENJ: ltnpt'oved Detection o f Rotavirus SheddlnB by Polymerase ('~hl|n l e • c t i o l l . Lartcet 1991, 337:323-325. WFI~ELL?d~ SCHOOKLB: C~OIMdAIMd~is o f Gene Expression by PCR. Biotechng]ues 1990, 9:318. WONGDM, WEINSTOCKPH, WETMURJG: Bt-anch Capture Reactions - Displacers 1Dmrtvedfrom Asymmetric IN~. Nudeic Acid~ Res 1991, 19:2251-2259. WONGKK, MCCLELLANDM: PCR With 5-methyidCTP RepLacing DCTP. Nucleic Acids Res 1991, 19:1081-10185. WRENBW, CLAYTONCL, TABAQCHALIS: N u d e o t i d e Sequence o f C/ostr/d/um ~ Toxin • gene Fragment and Detection o f Toxigenlc Strains by

67

65

Analytical biotechnology

DNA probes

Polymers~ Chain ge~m'tton. FEMSM/cmbto/Lett 1990, 70 1-6 YAP EPH, MCGEEJO~> Slide PCR: DNA Amplification from CeU Smnples on Microscopic Glass sllde~. Nucle~ At/dERes 1991, 19,4294 YOKOTAS, I~ANSEN-HAGGE~ , LUDWIG~D, PELTERA, RAGHAVACHARA, KtEPAAUERE, BARTRAMCR. Use of P o l y m e r s ~ Chain Resctinns to Monitor Minimal Residual IMease i n Acute Lymphoblastic Leuimmia Potients. B/~od 1991, 77 331-339 ZHANGW, DELSSEItOTHAB Effect o f Nudeotide Concentration on Slmcificity o f Sequence Amplification [letter]. Btotec.bnwues 1991, 11:60

DNA probes and automation Review: (pp 12-17) AGRAWALS, ZAMECNmPC Site Specific Functional/zmtion o f Ollgonudeotides fog Attlmhin8 ~t Different l~pot'tg~ ~ n l ~ . NlwJe~ Ack~sRe~ 1990, 18.5419-5423 ALBERIFONDG, SHERRINGTONP, VAUDINM. M a p p ~ N o n i s o t o p l c ~ rmbeled DNA Probes to Human C l m n e s o m e Bands by Confocal Micruaenl~. Genom/cs 1991, I 0 143-150 ALSRETSRNC, ~ I~l, HAUKANESBI, HAV/d~s'rEIN [S, KLEPPEKaA p p l k ~ t ~ o f M a l t e S e Beads

with Coveiently Attached oligonudentides in ~ t i o n - Isolation and Detection o f Spedfl¢ M ~ l e s Vinm M e ~ e n g e t RNA from a Crude Cell Lysate. Anad B~=,bem 1990, 189:40-50 BARANYF Genetic Disease Detection and DNA o • Amplification Using Cloned Thermustable l . t ~ . Proc Natl Acad Sci USA 1991, 88 189-193

Its1, BARANYF, The l l ~ r h . l n Reaction (LOg) i n a PCR • WoghL I R ~ M e ~ b ~ 1991, 1.5-16 [16]. BEDNARC2OKT~. ~GGR¢SRC, KONATGW. G~tteglttio~ o f High E ~ d e n c y , Single-Stranded DNA HybridLmtinn Probes by I~3L B/0techn~/u~ 1991, 10 478 BEJ A~ M/d~LrBAN1MH, ATLASRM ~ o f Viable

Legienella-l~enmophilain Water by Polymenme Chain Reaction and Gene Probe methods. A~pl Enmron Microkio11991, 57:597-600. BLOCHW A Biochemical Perspective o f the • Polymerme Cb~Ln Rtmction. Bux/~wntstry IS91, 30.2735-2747. [9]. BOgNTL M~D^ CG: Stained Colonies Facilitate Alla~m~ltt i n St NOl~t~Jdio~L~B~Colony llybridlzation. B/otechn/ques 1991,10:480-481 BROUSSET17,CtWITALS, ~ R D, ICARTJ, PAYENC, RIGAL-HUGETF, VOIGHTJJ, DEISOLG' I)~tL~L'tJOno f Epmein-lmrr Vlrus Messen~ler RNA i n ReedS t e c B l ~ Cells o f Hod~kin's Disease by i n Site ~ o n with Blotinylated Probes o n

Specialy th~cessed Modified Acetone Methyl Benzoate Xylene (modAMeX) Sections. B~oa 1991, 77.1781-1786 CAETANOaNOLLESG, BAg~AMBJ, GREg~OFFPM" DNA Amplification ~ t i n 8 Using Very Short Arbitrary O l l ~ m u d e o t i d e primers. Bu~.ecA,no/o~ 1991, 9 553-557 CANNONG Nucleic Acid ~ l u e n c e A t m l ~ S o M for M l m p n t e r s [Review]. Aria/Bu:~em 1990, 190 147-153. CtO*~DST, SCVmPAR'n~A. Polyethec T~ttt~'t~ Ollsooudeotide Probes. JAm Oxen S ~ 1991, 1136324-6326 CORn & TRtPPtrlXp, ~ G. Rapid mid Simple DNA Detection by Ilybrldization o n Absodmnt Filters. Nuc/eg Ac/ds/Ms 1991, 19:1351 C ~ C, KmS2mNBAUMM, LEONARDM, G I A N Q ~ L, VAIMANM isolation of Bovine Y - ~ Sequence -Potential use i n Embryo Sexing. Genomms 199L 10-646-653. Cox laD, Salines L, EVANST, LEVn~CHH: A Mom~ Sl[mCtlic

Polrmersse Chain ~e~ction (Pat) Vximer Probe Generation from Smmatic Cell ~ . Nuc/e~ A~/dsRes 1991,19.2503. DATFAAR, WENTZBA, RUSSELLJ Cloning o f the IAsteriolysin-O Gene and Development of Specific Gene Probes for Llsterla~ e s . AI~ Envtrtr~'Mmrobiol 1990, 56 3874-3877, DEMCZUKS, DONOVANM, FRANKLINM, OHLSSONK Ot'def o f Probe and Nuciser Protein Extract Addition can Determine Specificity o f lPhrotetn.DNA Complexes in Tested Mobility Shift A s a m ~ . Nuc3e~ Acu/s R~ 1991, 19.677 DtAWeO~ EP, OW.wIDPoutos TK Europium Cheiste IJbeis i n Time-Resolved ]Fluorescence ImmuocmssaTs and DNA Hybrldlzatlon Assays. Aria/Ox.m 1990, 62A1149

and

automation

DI,~,7~ 1, FORRSETSM, CAM£~HELLAC, SAGLIOG, PONZONE & COTTONRGH: Screeohlg for Mutations i n the Phenylaltnine Hydroxyisse Gene from I r o n - - Patients with I ~ e n y l k e t o n u r i s by Using the Chemical Cleavage Method.. a New Splice Mnmtion. Am f Hum Genet 1991, 48631-635 ERHCHHA, GELFANDD, SN~SKYJJ Recent Advances i n • the Pulymeratm C h a ~ Reaction. Sc:ence 1991, 252.1643-1651. [10]. ESPELUNDM, STACYRAP,JAKOBSENKS: A Simple Method fog G e n ~ ' l t h l g Single-stranded DNA lad~led to ltlglt Activities. Nut/ere AC~ R~ 1990, 18:6157 FAHYE, KWOHDY, GINGERASTR. Self-mmtained Sequence OO RepUcation (~SR): an/sothermud Trsmmriptionbased Amplification System Alternative t o PClL PCRMethApp11991, 1.25-33 [12]. FENWICKSG, MURRAy/kDetection o f i ~ t h o j ~ d c

Y e ~ a ~ m m ~ c o u ~ by Polymers~ Chain Reactiott [lett~]. Lancet 1991, 337:496 FERI~ RM, SMITHH, DOWNESE~ MCKECIEqED, I/riLE S

k p u s t Unit MultiprimmS and HylntdJmtion - tt Novel Method for the ~ u c t i o n o f DNA FJO~t8 U S J ~ M l l ~ t ~ U i t ~ Ptohq~. NUC/e/C A~/dsRes 1991.19:2505 F ~ C ~ U, L~6Em~LT~RP& MYESSOND. Producing $1~uq~le-Strsm~Jed DNA Probes with the TJ~q[DNA Polymegese 4 High Yield ProtocoL Bwtechn~tues 1991.10.35. FODORSPA, READJL, P~RUNGMC, STRVERL, LUAT, SOL/6 o o D: IJght-IMrected, SlmtLally Addremmble Parallel Chemleal Synthesis. Saence 1991, 25'767-773 [47]. F~m B, LAmENSH: Oll~mucleotide Pmrification in Mltliot-~m Qultntities. Bt~tecbmqu.~ 1991, 1~.420-422. GA~ E, CHAPDEIAINEP, TEEMBLAyRR, DUBEJY.

Northern Aual~is of Gene-Specllic Primary Transcripts Using Synthetic O l l g o n u d e o t i d e Ihrob~ Libeled I t High Specific Agtivity. NucJe~c A~Iki[sRes 1990,18:7450 GILBEgrDA, REIDYA, GAILMid, PEE D, WHITEC, HAYRJ, OBI~N SJ. AlppUcation o f DNA ~ t s for CeU-Line lndividtmll~attion. Am f Hum Genet 1990, 47.'499-514. GOI~M.RZCADAVIDN, GATrlRA. N E ~ H Automated

Direct Seqmm¢tnS of Potymer~e

rag.t,,

ihmction- Amplified Fragments o f the H nms" Eis-rw Gene. Anal Bioclx.m 1990, 191 359-364 GUlU/RJI~T, Rt.'BINSTEINDB, YOUNGF, TUCKERI~ LCmT~N~RRGT, ~ A m ' Z RS, ~ KJ. Individual Via Genes Detected with O l l s o o u d e o t i d e Probes fa"om the ~ p l e m e n t ~ ' l t ~ - l ~ t e r m i n i n ~ BeSiom. ] Immuno11990. 145:1934-1945, HAASl~ SUBBARAOSM, HARDERT, LIESSB. BARKETrT Detection o f Phocid Distemper Virus RNA i n T i ~ u e s Using Slot Hybridization attd t h e Polymemme Chain Reaction Amplt~cation Assay - Getmtic Evidence timt the Virus is Distinct from C.amit~ Dlt~'~ml~'r Vlrtm. J Gen Vwo/1991, 72:825-832. HENDERSONGS, CONAI~.IT, DAWmONJM, STEWAR~SJ, HOUSE FS, MCCURt~TL A Reliable Method for Northe~a

slot ~ l ~ i s

tm~z Synthetic Ollwmaudentid¢

Pgob¢~. B/ote~n/ques 1991, 10,190-197 HERMANGE, BERRYM, MUNROE, CRAIGIW, LEVYER: The Constructiott o f Human Somatic Cell I ~ o f / d s CO~tainlno PogtlOlX8Of the Momte XChromo~mme and Their role to C~nerst~ DNA

Probes Via interspersed ltepetHive Sequence Polymerese Chain Reaction. Genomw~s1991, 10,961-970 HOIX3SONCP: A DNA Text Code. Biotecbmque$1990, • 9312. [49]. HOLIANDPM, ABRAMSONRE),WA1SONR, GRLFANDDH • Detection o f Specific Polymerese Ch-!n Reaction Pfodnct by U t l l i t i n o the 5"-> 3"Exonuclease &Cttvity o f Tbermus Aqlm~/cms DNA PoIymermse. Proc NatlAcad S~i USA 1991, 887276-7280 [18]. HO~AKAH, SUZUKIY, SATOH, GUG-K~MS, TAKAKUH. A Convenient Approach to the S y n t h ~ o f

Medium Size OligodenxTrtbonucleotides by l m p t o v e ~ New Phoephite Method. Nucleic Actds Res 1991, 19:2935-2940 HURSKA~SW2qp, DAHLENP, YLIKOSglJ, KWIATKOWSKIM, SIITAPd H, LOVGRENT l~,q~trStinn o f Europium-Labelled DNA ~ and ~ Properties. Nuc/e/c Actds Res 1991, 19:1057-1061 IVANETICHKM, AKIYAMAJ, SAN~DV, RESCHENBERG M Autommted Purification of Synthetic O l l g o m t d e n t i d ~ . Btotecbn~/ues 1991, 10.704 JAPOORAJ. CHA'rIsP& EIGENRAUCHHA, CRUMPACKERCS Detection o f Human hnmunodeflclency Virus Typed Clinical Isolates with Reduced Setmitivity to Zidovudine and Dldeoxylnoeine by 1UqA.RNA H~idib'mtion. proc Natl Acad Sct USA 1991,

88.3O92-3O96.

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sequencing Related review: Detect,ons of mutations

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69

70

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(Vent

TM) m ~

l ~ m r m ~ e d by t x - t m m a t ~

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Aet~amlde-rich Copolymers. a*~ec../m~ques199o, 948O--485 CIORA1", DEN~FLEP, MAY^UXJF: Rapid O n e - t ~ Automated Sequenci~ 8 Re•¢tions for 16 DNA Samples Usin~t T~q Polymer•se atul F[uoee~ent Primers. N~/e/c Ac~fs Res 1991, 19:188. Ctm TM, B~ELL JL, H O ~ MK B~dX~ B& l~Ci• F m t ~ q ~ t n t l ~ for Selection o f ~ Mmched Unrelated Marrow Donors. Lancet 1991, 337 1049-1052. [33]. COLEKD Purification o f Plmmid mad l f l # Molecular M s ~ DNA Using PIF~-~dt Two-PIm~ ExtP•¢tion. B/otedm/ques 1991, 11.18 COmGUOC, PAPPASG, GILLWJ, KASHDANM, MANISCAI~O M. Submmomole Detection and Quuntimtion of ~ Specific Activity P.32-Nudeotides. Btoted0n/ques 1991, 10:452. COOMBSLM, PIGOITD, PROCTORA, EYDMANNM, DENNER J, KNOWLESM& Simultaneous lsulatiou o f DNA, RNA, Stul Antl~-'~c Proteht I~whmitin8 Kiuase Acti~ty from Small Tumor S~tmples Using Guanidine lsothiocyanate. Ana/Bg~9~ra 1990, 1~1.338-343 COURTDA, BERTRANDH A Method for ~-quenclng Uncloned Termini o f Linear P l u m i d & Nude/c Actds Res 1991, 19.1714

CRF.ASEY& DANGIOL DUNN~'IS, KISSINGERC, OKEEFFET, PERRYO~EFE H, MORANLS, ROSKEYM, SCH]LDKRAUT I, SEARSLE, SLATKOB' Application o f • Novel Chemliumin¢~ge~cgoB~lgd DNA Detection Method to Si~#e-Vector and Multiplex DNA Seque~ctnli. BtotecbnNues 1991, 11.102 CUNYG, VEASF, RO~mSG Pocket Blotting - • Method for T ~ s f e r r t h g N u d d c Acids Onto Nylon M~abt~aes. Anal Bu~J~ra 1991, 19345-48 DE BELLISG, MAN•N1M, PERGOI~Z~IL VEZZ£)N~P. 1MZZANAM ~ef ID~slg~ i n l;luove~e~t DNA Sequoncln 8. Nuok~ A~/ds Res 1990, 18.4951 DEARPH, COOKPR: Ceihdat Gels -Puttfylit8 and Mapping Lon~ DNA Moleculca. BtochemJ 1991,

273.695-699 DEGLI-INNOCEN'HF, FERDANIE, PESEN~-BARII]B, DAM M, GIOVANNETn~, VENTURAS Identification o f Mlct'obi~ i s o h t t ~ by DNA ~ r i n t i n g : A~tlysls o f ATCC Z . v t u o ~ o ~ t Stmlns. J B/otechno/ 1990,13 335-346 DIABEA~I, ~ L I A C, SAGLIDG, FORRESTSM, RAMUS • S, COITONRGH Simultaneous Screening for B Mutations by Chemical C I ~ of M~tmttch. Genora~s 1992, i n P r e ~ [201. DIJKWELPA, VAUGI~JP, ~ JL IM[~l~ll~go f l e p H c • t i o n Inithttion Sites In Msmmsliao Gemmaes b y Two-Dimeminnal Gel Analysis $tabflLtation mad Enrichment o f Replication intermediates by Isolation o n the Nuclear Matrix. Mo/Ce//B/o/1991, 11'3850-3859 Do N, ADA~ RP: A Simple Technique for Removing Plant ]Pol~mccbarlde Contamimmnts from DNA. B/otecbn/ques 1991, 1~162 DOCmOgS-DWO~lCZAgB, DWOgSaC2AKB, B~O~V~Lg~m • L, BULLKSJ, HORSTJ, BOCgERWW Non-isotopic Detection o f Single Stnmd Conformmtion

~ o ~ r m o r p h t ~ (PCa~ssc~): • Rapid and S e ~ i t i v e Technique In Diqlncala o f Phenylketonurla, Nudeg Acufs Res 1991, 19 2500

[221. DOLINNAYANG, PYATRAUS~mN~OV, SHABAROVAZ& ~ g DNA Triple Helix Structure by Chemical USatima. FF_.B~Leu 1991, 284.232-234. DRAKJ, CROTHERSDM- Helic•i Rep¢~ a n d Chirality Effects on DNA Gel Electrophoretic Mobility. Proc Natl Ac~d S~I U S A 1991, 88 3074-3078. DUKED, CHAOW, NYMANLP: Standardized lsohttion o f Protoplmsts. B/otecbmques 1991, 10.166 EDWAR~K, J ~ N E C, THOMPSONC. A Simple and ILtptd Method for the Prtlmration o f Plant Genomic DNA for I ~ R Analysis. Nude~ Ac/ds Res 1991, 19'1349 EIKENHG, ODLANDE, BOMANH, SKJELKVALEL ENGEBRETSEN IF,/WOLDJ. Application of Natural and Ampli~cation Cre~ted Restriction Sites for the D i ~ n ( ~ i s o f PKU Mutations. Nu d e g Acids Res 1991, 19.1427-1430 ERRINGTONJ, A Rapid and Reliable One-step Method for Isolating DNA ~ e n t s from Aiprtme Gels. Nude~ Adds Re$1990, 18:5324. FANGZT, CASTROCE. Simple Modification o f the Sin#eStep Method o f RNA isulatiott from Rat Liver. Btotet~n/ques 1991, 10734 FAZ,M(ERI~JK, Sou'r~RN P, BLOOMF, BUCHMEIERMJ. Resolution h w l t u Hylzridizmion to Determine the Celiubtr Distribution o f Lymphocytic ChoriomeninSltis Virus RNA i n the Tissues o f P e m f s t ~ t i y Infected Mice - Reicmmce to Aretmvtr~ ~ and Meclmm~ms o f Viral Persistence. f Gun vim/1991, 72.1611-1625 FENNBJ, HERMANTM. Direct Qumatitatton of BlothaN u d e o t i d e Analogs i n I~IA Trmmcrlpts. Ana/Bgtc.bern 1990, 190.78--83 FEY MF, Tonms & Assessment o f DNA l r i n ~ t i n 8 as • Method for Validating the Identity o f Omcer Cell Lines Maintained In LonwTerm Cultuee. N ~ / e ~ Ack/.~R~ 1991, 19 3464 F~NgPS: Usin8 Sodium Chloride Step Gradiems to F ~ DNA Feagments. Bmtechn/ques 1991, 10.446. FLAEGSTADT, SUNI~FJORDA, ARTHURRR, PEDERSENM, "I'RAAVmT, StmRAMA~S Amplification mad Seque~cin 8 o f the Control R O O m o f BK and JC Virus from Humam Urine by P o l y m e f u e Ch.e. Reaction. V~ro/o~ 1991, 180:553-560 FORP.ESTSM, D*HLHH, HOX~Lk~DW, DL~g~a I, COTTON 0 • RGH Mut•tion ~ o n i n Phenylketonurht Using the Chemical Clemm~ o f Mismumtch Methodt Importance o f Using Probes from Both Normal and Patient Samples. Am J Hum Genet 1991, 49.175-183 [16]. FOTADARU, SHAPlI~LE, SURKSM1, Simultaneous use o f Standard and Low-Melting Agartme for the Selmmtion s n d Isolation o f DNA by FAectrophoresis. BtoteOmtques 1991, 10.171-172. Fox ES, THOMASP Modification of the Rapid Method o f Evans and Kamdar for Application to

lsoLttinn o f Messenger RNA from Kupffer Cells. Btote#fawlues 1991, 10.182 FREI~ B, LARSENSH. Oligonucleotide Purification in MllHaram Quantities. Bt0tedm~/ues 1991, 10 420-422. FROTmNGHAMR, ALLENRL. W~SONKH' Rapid 16S I~Ibosom~ DNA Sequencing from a Single Colony Without DNA Extraction o r Purification. Btotecbn~lues 1991, 11.40 GANGULYA, BALDWINCT, STROBELD, CONrCVAYD, HORI~NW, • PROCKOPDJ Heterozyl~us Mutation i n the G + 5 Ptmition o f I n t r o u 33 o f the Pro41pha2(l) G~2ne (COLIA2) that Catmes Abernmt RNA Splicing and Lethal O s t e o l ~ e s i s lmperfecuL y B/o/Oaem 1991, 2.66.12O35--12O40. [28]. GANGULYA, PROCKOPDJ. Degec~on o f Si~lle-lmae • • Mutations b y l l e l c t i o n o f DNA Hetegoduplexes with • W•ter-suluble Carbod;imide Followed by Primer Extension: Application to Products from the Polymeglmc Chuin Rtmction. Nta:/e/c At/aS Res 1990, 18 3933-3924. [27]. GILBERTDA, REIDYA, GAILMH, PEE D, WHrI'EC, HAYRJ, OBRIENSJ. Applicatiou o f DNA lrtn~'gprlnts for Ceil.Mne hldi~tdutdizJtion. Am y Hum Genet 1990, 47 499-514 GOGOSJ& KaRA~ORGOUM, ABtmATANIH, KAFATOS • FC Detection o f ~ B u e l~Jm=*eh4~J o f Thymine trod O~tosine Residues by Potmmium ~ t e m d I ~ / d r o ~ h u n i n e i n the ~ c e of Tettal~-mmmomdum Salts. Nude~ ActdsRes 1990, 18.~fi807-6814 118]. GONT_AI£ZCADAVIDN, GAT~ RA, NEOwl~lrtH: Automated Sequencln s o f FolymefaJe Chain Reaction- Amplified Ffasmenm o f the Human Ela.rm (R~ae. Aria/B/~/x'm 1990, 191:359-364 GOODEBL, FEm~'TEtNSC R ~ t r l ~ t i o n Idappin8 o f Recombitmn¢ Gmnma-DNA Molecules Using Pulsed Field Gel Electm~horesis. Ana/Bux~m 1990, 191-70-74. GUIDErF, ROGOWSKYP, LANGRIDGEP A Rapid Method o f Prepm'lng Megslmse Plant DNA. Nude~ Ac/ds Res 1990, 18;4955. GUNDERSONK, CHU G: Pulsed-lqeld Electrophoresls of M ~ - S L g e d DNA. Mo/CeU B/O/1991, 11:3348-3354 HAMILTONB~ PALAZZOLDM~, MEYEROWrlXEM' Rapid isoistion o f Long OI)NA C l o n ~ from F-atiSt~ll Idbrmries. Nu~/eg Adds Res 1991, 19:1951 HAN M, STERBERGp~7. Let-~. • ~ tiMIg~'L~[le~l • Cell Fates During C. E l • p u s V u l v ~ Induction, FJtcodes • n u P r o t e i n . Ce//1990, 63.921-931 [17]. HAg~ RN, •CALLA•SANDJ: hmlation and Purification o f

speciac, o v ~ J p p i n 8 Mesee~tser P.NA specle~ by Electroeiutima fa'om A p r c a e Gels - Benchmark ~etter]. B/otecJmg/ues 1991, 10'728. HATAA, ROBEgrSONM, Et~ M, LAIOUELJ-M. IMrect u Detection and Automated S t ~ l u e ~ i n 8 o f Individmd A l l d ~ ~ Electrophott.tie Strmad Sepm'ation: ldentBlcation o f • Common N ~ Mutation i n ]F,x o n 9 o f the H ,trash lapoprotein Lipme Gene. Nude~ Ac~s Res 1990, 18:5407-540~ [2~1. HED^ GD' A Simplified Method o f Itmert~ft ltadiolabeied Nucleic Acid Probes into Blotting B~qls. B/~eO~mques 1990, 9.563 HENCOK, HEIBEYM: Qumatitmttve PO~ the • Determltmtion o f Template Copy Numbegs by Temperature Gradient Gel Electrophores~s (TGGE). Nuc/e~ A~/d$flus 1990, 18.-6733-6734 [13]. HmAO 1, YOSmZAWAS, MIURAIC Gel Elcctrophoresis Using • Fluoreacence Agent for Analysis and Purification o f N o n - ~ Synthetic DNA Frqlments. Nuc/e~ A ~ Res 1991, 19:4003 HOmON K, StNGHSP, LAV1NMF: Use o f DNA Protein I~tegaction to Isolate Sl~mclficGun•talc DNA Sequtmce~. Anal Biochem 1991, 193-220-224 H O F M MA. BRIANDA: Sequeucl~g PCR DNA Amplified ~ from a Bacterial Colony. Btotec,bn ~ues 1991,11 30--31 HOLLANDERMC, FURNACEAJ Estimmtion o f Relative Messenger ItNA Content by Filter ~ t i o n tO • Pulytilymldyhlge I[h"ol~. B/otechn~/ues 1990, 9 174 HORNF.SE, HULTMANT, MOKS1", UHLENM Direct Cloning o f the Humm~ G~llOt~lC Apolipoprotein-E Geame Using ~ e t t c Setmmtion o f Slnsle-Str•nded DNA. B:otechn~/ue~1990, 9.730 Hsmo i~ A F ~ t and Simple Procedure for Sequencing Double Stnmded DNA with Sequemme, Nude~ Actds Res 1991, 19:2787 HUANGGN, KRUGHTI~ l ~ - S c ~ l e Purllicltiou o f Synthetic Oligotmcleotldes and CarcioosenModified Olisodeoxynucleotides o n • ReversePhase Polystyrene (PRP-1) Column. arm/B~ochem 1990, 190.21-25 HUANC,XH, SHEARJB, ZARERN. Qmmtimtion o f l~Ibonudeotid~ from Hase-Hydruly'~-d I~IA

..

Analytical

using Capillary Zone Eiectrophoresls ilett~], Ana/OE, m 1990, 62:2049-2051 HULTMANT, BELCHS, MOKST, UI~ENM' B l ~ o t m l Solld-Ptmas Sequencing o f Invitro-Amplified Pbmmid DN&. Bzotecbn/ques 1991, 10.84 ITO T, OHGUSUH, O~m N, SAKA~Y. An Improved Palasd-Fleid Polyacrylamide Gel Electrophoresis System for Physical Selection of tJnkhag Clon4~ . Isolation o f SRI lJnlktn~ C/ol~tes f3~tO • Oht'omosome 21-Spedflc IIbrary. Genomms 1991, 9 707-712 JACOBSONIO3,ARLINGHAUSHF, S C ~ H~7, SACHLEBEN RA, BROWNGM, THONNARON, SLOOPFV, FOOTERS, LARIMERF'~, WOYCH~ RP, ENGLANDMW, BURCHETrKI, JACOBSONDA. An ~ to the use o f Stable Isotopes for DNA Sequettcing. Genomtca 1991, 9 51-59. JACQUESJ-P, SUSSIONDMM Use o f E l ~ t g o p h ~ ¢ Mobility to Determhle the Secot~a'y S t r u c t u ~ o f s small Antlsenas RNA. Nuc.letcAcids Res 1991, 19 2971-2977 J~tN MJ,J~L~ D, KtrM~ AM, SOU.D: Mono Q C h r o m ~ t n ~ t p h y Permits B e ~ d i n l l o f DNA Template and Purification o f RNA Tnmasrlpts lifter 1"7 RNA Polymerm~ Rtmction. Nuc/e~ Acrds Res 1991,19:2786 JOHNSONBS, TIE~GJPH DNA lqn~.~id~nting with S-35 Nucleotides. Nuc./eu;Ac/ds R~ 1990, 18.7459-7460 JOy, SON KR. A S t ~ - S ~ Ptasmid Prellmmttion Yieldin8 DNA Suitsble for Double-Stranded Sequencing and i n v i t ~ Trtnasription. Ana/ B/oc.bem 1990, 190"170-174. KALUZS, REInKBM:A Novel ~ Method for l)etet~on of ~ Products. Nuc/e/c AckarsRes 1991, 194012 IO~a~ut H, NACaaK, I - I A ~ S. Re~ Time Automated Simidtaneous Double-Strsmded DNA S e q u e n c ~ 2-Colue Fluorophore Lal~ling. Bu~o~no/ogv 1991, 9.648-651 KANEOKAH, LEEDR, HSU KC, SHARPGC, HOFFMANRW Solid-Phase Direct DNA Sequencln B o f &lieleSpecific Polymenme Chain Resction-Ampllfled HLA-DR Genes. Bg0teogn~]ues1991,10:30 KAUFMANDI~ RAVmSHV, MCCLATCI~YAI, MEh~S JH, TORn~ OO AJ'.Detection o f Point Mutations Amo¢iated With G~llXe~cb by ~ Axo~ St~tnnlng Technique. C,enom~cs 1990, 8.656-663. [6]. KEENJ, LESFERD, INGm~mm~NC, Ctmm A, BHA~'rACHARYAS o e Rt4~d Detection o f Single I~tas Mismatches m Heteroduplexes o n Hydrollnk Geh. Trends Goner 1991, 7'5 [291. KEEN,TJ, I ~ G ~ CF, LESTEEDH, BASHmR, JAY M, Brad • AC, JAYB, BHATTACHARYASS. A u ~ Doll~hMl~t Retimdtls Ptlgmentosax IFout"New MutstlOt~ in ~ i n . One of t h e m in the Retinal Attschment Site. Genom/cs 1991,11 199-205 [30|. K~MBAT~FM, ELYB A Method for the Determination o f Sequence o f ~ G + C - Percent DNA by the Sequential Application o f Sequetmas mid T~q Polymer~e. B/oteam/qu~ 199o, 97N. KHANAS, W~COXAS, HOPKINSJA, SI~IA JM E m d e m Double Strmmkd Sequemcin8 of CDNA Clones c o n t s ~ m s Lona Poty(A) Tatis us~u~ Anchored Poly(dT) Primers. Nuc.Je~ Aads Res 1991, 19 1715 KIBENGEFSB, DYBINGJl~ MCKENNAp Rapid Procedure for Iarge-Scale l~ol•tion o f PL~mid DNA [letter]. B/otecbn/qu~ 1991, 11..65~67. KONRADM. I l l . t o l d DNA ~ u e n ¢ l n g Using Hiff)~[y Dt~mmmte OligmmcleotMes as l~'imtnm. Nudem Ac/d$ Res 1990, 18:5320 KOVARH, JUG G, AUERH, SI~ERNT, BLMSD. TWo • D i m e m l o m d Single~strand Conformatfon Polymorphlsm An~lysis: • Useful Tool for the Detection o f Mutstions i n Lot~ DNA Fr•smonts. Nut/ere Ac/ds Res 1991, 19.3507-3510. [21]. KOZAKKR. FOSTERLM, ROSSIK: A Method for

T r a m f m ' r i ~ Seqmmang Gels from Gla~ to A b e , bent Filter Paper [letter]. B ~ b m q u e s 1991, 11:54. KRISI-B~IANBB, BIAEESLEYRW, BERGDE: Lid~te Amplification DNA Y.mquen¢ing Dlrettiy from Sinsle Ptm~e Plaques and Bacterial Colonies. NudemAcidsRes 1991, 19-1153. KROPP Gt, FUCHAROENS, EMBURYS H . / ~ m t l l l ~ x t l ~ l i y Primed Se.l~'~ve Ampliflcationfrempecatore shift Fluorescence Polymeraas Ckadn l~caction tO Detect the H e ~ g i n b h l Cotmts~t Spring Mutation. B/ood 1991, 78:26--29 KuO Wk TENJ~NH, SEGRAVESR, PINKELD, COmus MS, GRAYJ: ~ o n o f &neupinldy lnvol~l~g C/xromc~omes 13, 18 og 21 by Fluogesconce In Sltu ~ d l ~ t t i o n (FISH) to l n t e t ~ l m ~ and Met~ph~se A m l ~ t ~ l . A m J H u m Get~t 1991, 49112-119 KUPPUSWAMYMN, HOFFMANNJ'W, KASPERCK. SPH'ZER • SG, GROCESL BAJAISP Single Nucleotide Primer Extension to Detect Genetic Diseases:

biotechnology

E x ~ r i n m n t s l A t ~ l l ~ l t i n n to Hemophilia B (ll~K~" IX) mid Cystic Filmmsis Gtnaes. P r ~ Natl Ac.adS¢tUSA 1991, 881143-1147 [41]. KWANH, LI C, ~ S, CHENGS A Simple Method to Prepare Intact Ye~mt Obromooomat DNA for Field Gel E l ~ h o r ~ l s . Nucle~ Acids R~ 1991, 19 1347 LACEYSF, SDZUTANIT, POWELLKL, PURIFOYDJM, HONESS RW. A n a l ~ l s o f Mutations i n t h e Thymldtoe Klmme Genes o f Drug- Reststmat varicella-Zoster P o p u l a t i o m Usin8 the Polymerme o m , n B ~ c t i o n . J Gen Vtro/1991, 72 623-630 Lm~ PW, ZODERV~kO& ~ S K, RLrDr,nCm MA,JAENtSCH It, BERNSA: Simplified ~ a t m m l l l t n DNA hmlstion Proce~hL~. Nude~ Ac/ds Res 1991, 19.4293 LALLOZMRA,MCVEYJH, PATrE~ONJK, TUDDENH&MEGD memophIRa-A m ~ n o s ~ by Analysis of • ~ l e D i n o d e o t i d e Repe~t Within the l~-'tt~-~lll Gene. Lancet 1991, 338.207-211. LEEJS: M t e r t m t t ~ D t d ~ x y ~ q u e B c i n g o f DoubleSUrtmded DNA b y Cyclic Reactions Using Taq Polymer~m. DNA Co//Bto/1991, 10-67-73 LEESY, RMHEEDS' A Simple Procedure for Mmrlmum Yield o f High-Quality Phmmid DN&. Bmtedm~/ues 199O, 9.676-679 S, UEIBANO-ISpIZUAA, GILLP~THOMASDM, G I L B ~ N • J, FOSTERC, MARSHALLCJ. Multiple K-rm Codon 12 Mutations i n C / t o l a n # o c a r ¢ i n o m ~ Demonstrated with • Sensitive Polymerase C h a ~ Reaction Technique. Cancer Res 1991, 51:3497-3502 [45]. LICHTENSTEINAV, MOISEEVVL, ZABO~INMM. A Procedure fog DNA and KNA Ttamsfer to Membrane Pliters A~'~ll!n=o w e i ~ t - l n d u c e d Gel Flattenh*o=. Anal B/ocbem 1990, 191.187-191 la~ YC, C~ou YC. lFormaidehyde in Formaldehyde Gel M•y b~ I~Jimlnated Without

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Haemophllla a Patients by Rapid ~

of

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2.0.

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KARUBEI Microbial Sensor. J Bmtechno/1990, 15.255-266 KARUBEI, SODEFL TA~flY^E Microbiosensors. J B/otechno/ 1990, 15.267 KAWAKA~M, KOYAH, GONEX~S. I m u m ~ o t l of Enzyme t o P ~ t i n u m Electrode and Its use as Ellzyme Electrode. ~ B/0cbem Bk~/ano/1991, 28-29.211-219. KIEFERH, KLEEB, JOHN E, STIERHOFYD, JAHN1GF B i o ~ n s o t ~ Based o n Membnme Transport Proteins. Bmsensors 1991, 6'233238. KIMURAJ, KUPaYAMAT FET Biooensors. J Bwtecbno/1990, 13.239-254. KOOYMANRPH, LENFERINKATM, EEN1NKRG, GREVEJ Vllzr~inB Mirror S u r ~ c e Flesmon Remmance Immun~ensog. Aria/~ 1991, 63 83-85 KOUDELKAM, ROHNER-JEANRENAUDF, TERRETTAZJ, BOBBION1HARSCHE, DE ROOUNF, JRANP.ENAUDB. In-vtvo Beluwiour o f H y p o d e f m i a d l y ltaphmted Mict~fabricated G l u c o l e Sensors. B~ensors 1991, 6.31-36 KULYSJ, D'CC6TAEJ: Printed A ~ l p e t ' o ~ t ' l ¢ Sensor B a ~ d o n TCNQ and Chollnestega~. B/o~tsors 1991, 6:109-116 KULYSJ, SCHMIDRD: Blenzyme Setwors Based o n Ohemicaliy Modified Electrodes. B/oaensors 1991, 6:43--48. KONNECI~W, SCHMIDRD. Development o f • GIs Diffusion lrtA System for On-line Monitoring Ethanol. J B/otecbno/1990, 14:127-140. LEECS, HUANGPY, AYRESDM haduced Electrostatic Potentltls o n Antigen-Antlbody Complexes for Bimmalytical A p p H a t t l o ~ . Ana/Gbem 1991, 63 464-467. LEONGKH, ENSELLG, WALLP, PICKARDRS: Multiclmmmei Mleroelectrode Probes Mmchined in Smcon. Bwsensors 1990, 5:303-310. LEoN-GoNzAw.ZME, TOW~HEND& Mow-Injection • Determimttion o f P m ' ~ x o n by I n h i b i t i o n o f Immobilized A c e t y l c h o l i n e s t e r ~ . Area On'm Ac~ 1990, 236.267-272 [43]. U YP~ CHUJ. Study of BOD Microblal Sensors for Waste Water Trtmtment Control. ~ B/ochem Bg~bno/1991, 28-29.855-863 LINDl~ CONNOLLYP, WIUflI~ONCDW, BRECI~NRII)GE[J, DO• JAT Single Cell Mobility and Adheainn Monitoring Usin8 ~ l i n l a r Electrodes. B~ors 1991, 6:359-368. [/TWILERKS, KLUCZYNSKIPM, BRIGHTFV. Detel"mlnatinn o f the Tt'masduction Mechanism for Optical Sensors Based o n Rhodamine 6G Impregnated Perfluorosulfonate Films Using Steady-State and Frequency-Domsin Fluorescence. Anal OJera 1991, 63 797-802 L[U HJ, Yu JC, Bn~lmADS, GIVENSRS, W1L~ONGS" Flow lnJectlott Solid-P~lse Chetmliumlnescettt ImmtltnOaSSl~ USiMt~• Membl2m~-]~MiL~]R4~ctor. Anat Om.n 1991, 63'666-669 I~FFI.ERO, WIEIV~IOFERliD, GOPELW. ~LlmpeEomm~tric Biommsors." ~ t i o n o f Dispersed Mediator Symems. Bm~n.sors 1991, 6:343-352 LUDIH, G a ~ MB, BATAEJ.ARDP, W1DI~RHM: Flow

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by r a n i s

~ ~ro-~d~-cetar~

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monitoring RA'ITRAYF2tS, PROSSERJl, KILLHAMK, GLOVERLA. Lumin¢~cence-Bled Nonextractive Technique for i n s i t u Detect/on o f EscherichJa-Coli i n SoU. Environ Mtcrobto11990, ~6:3368~3374 RECF~XTrgC~ HO MY. Blo~mm~s Based o n Cell and Thmue MMeri~l. J B/otechn~ 1990, 15 201-218 P,ISF~ONJ, GOTTESFELDS I I ~ l ~ t i O ~ Of Polypyrrole/81ucose Oxidmm Electrodes by ~liipsometrtc. Mlcrosra~tmetrtc and Electrochemical Me•sufemems. Bu~enaors 1991, 6:143-150 ROBL~ONC ~ O p t i ~ d lmmualato~e~Jfmg Systems M e e t ~ t h e Market Negds. Bzos~zR~ 1991, 6:183-192. RODA• ~ S, GRIGOLOB, GHINIS, CARREAG, BOVARA Z~l I, C,RIMAL~1~ Ml¢rtMlmlysis and I~,mit,~scent l"rolm, A m ~ t i c a l and Clinical , ~ , c m . B/c*ensors 1991, 6:21-30 RO6mS KIL Vxums .]0, EumFa~sm ME. Effects o f Receptor Concert•tin•ion, Media PH and S ~ on Nlcotinlc Receptor.mmsm/ttcd Signal ha • fiberoptic Blo~msor. B/~emors 1991, 6:1-9, ROSARIOSA, CHAGS, MEYERHOFFME, TROJANOWICZM Use o f l o n o m e r Membrtmes to Enhance the Selectivity o f ~lectrod~BmJed Bioeensots in Flow-lnJection &amly~. arud O0em 1990, 62:2418-2424 ROOlSrONSA, Cm~UN MF, DUN~ LJ, CL,~KAD De~r.lopment o f an Fatzyme Subs•rate Incorporating S e m i c o n d u c t l ~ Amorphous C1u'bom~ for tree i n Bloc•molto. B/~ensors 1991, 6:325-332 SATOHH, HAYAS~H, NODAN, TERADAH, KOBAYASkq A, YAM&S~BTAY, KAWAIT, ~ M, YAMAZMUN Qmmtt~cation o f lntr~cellular Free Sodium Ions by Using • New Fluores~mnt h d i ~ t t o r , SodinmBlndin~ ]94~t•ofulP&n isophthalate in Guines PM Myocytes. B~oSera 8to/~aysRes Comraun 1991, 175.6H-616, Smo~ ~ An Apoenzyme Thermistor Mlcmmmlysis fog Zinc(H) h m s with use o f • n Immobilized ~,t~um~. Phosphatme ~ a t c t o r i n • Flow Ss~tem. B~sensors 1991, 6:375-380. SATOH1, AOKIY: Blommsing o f Zinc ( l l ) Ior~ Using e o an ~ R e , m r ~ml an ISFL~ Detector i n Flow Su'e•wm. ~ .A~sa,ku 1990, 58:1114-1118

[s21,

SCHELLERFW, SCHUBERTF, NEUMANNB, PFEWFERD, H~N'T~ ' M~H~R, DRAI~FELD1. WOLLENBERGERU, RENNEBERG R, W~S~rmEA, JOHAmSONG, SKOOGM, YANGX. BOGDANOVSKAYAV, BUCKMANNA, YU ZArPSEVS. Second Gmx~mtlon B ~ . Bmuemors 1991, 6.245-254 SCH~m~RD, KUNNEOOSW Flow InFection A t m l ~ i s (FIA) Based o n Enzymes o r / m t i b o ~ e s ~ Application i n the ~ Scleno~. J B~otedm~ 1990, 14:3-32 SCHUHMANNW, ~INER-EBERLE R L~lln~tion o f Po~le/81ucoee Oxidmm Electrodes i n Flow. injection Systems for Sucrose D e t e r ~ t - ~ t i o n . Bmwna0m 1991, 6:263-274. Sc~rr RE: Therapeutic Drug Monitoring. Aria/~xom 1991, 63:R18~-R192 So4 KW. D~velopme~t o f • Se~asor for Ethmnol. B/~msors 1990, 2:311-326. S~ KW Bioelectro~hemical I]mtec'flon o f Three M e o l m b I~ued o n • Conducting ~ c Suit ~ . Bmsenaors 1991, 6317-324. SIMONIANAl, KHACHATR~qGE, TAT1KIANSS, AVAKIANTM,

BA~U~ m. A Ftow-throut~ ~=~me ~ n ~ x e t for D e t e r m i n • t i o n o f Dlysine Concentcation. B/~ser~0rs 1991, 6:93-100 SKEENRS, KISAALITAWS, VANWm BJ, FUNGSJ, BARNESCI> £~mhmtton o f Neugon-lmsed Sensing with the Neut~"~msmittet Seroto~in. Bt.ose'nsta~1990, 5:491-510 SMrr MH, ~ AEG. Or•hide Detection Using • Substrate-aq~aeratlng, Peroxlda~- h s e d B ~ . Aria/O0em 1990, 62:2429-2436. S~rrH ET, FE~BERGB& Redox Propet~ca o f Several l~-doxlm Using Sqtmre Wmm Vo|~mm~'tty. f B/O/C~om 1990, 265 14371-14376 STEFUCAV, GFav~JNERP. KURRIL~AI, DAN1ELSSONB, BALESV ApplicatiOn o f the Enzyme T h e t m i m o r to the Dit'ect Fatlmmtion o f Intrinsic IUnetics Using the S~xlmroor-lmmobllized InvorUme System. Enzyme M~cr0b Techno/1990, 12:830-835. TABATAM, TOTA~ M, Mug~cm T. Determimmtions o f Imctate a m i Iatctate Dehydrogemm¢ Activity In Serum w i t h the Flow In}ection Analysis System htvolivlitgI m m o b i l i t ~ ~ Column • rid C h e l n l l u m l ~ e n c e . AnalBtoc.bem 1991, 193:112-117 TANGHT, I ~ H K, ~ HB, HEINEMANWI~ FlowInjection Analysis with ~lectrochemical Detection o f Reduced Nlcotinamide Adenine D i n u d e o t i d e UsIng 2,6-1Mchloroi~lophenol as • Redox Coupling Agorot. Aria/B/ot:~om 1991, 192.243-250

THAVARUNGKULP, I-IAKANSONH, HOIATO, MA'rlIgSSON B Continuous Monitoeing o f Urea i n Blood Dialysis. Bmsensors 1991, 6:101-108 TSOMPSONM, IC~ULLUJ Biommsot~ and the Trmtsduction o f Molecuitu" Recosnltion. An•/ Cbem 1991, 63.A393 TRAN-MINHC, PANDEYPC, KUMARANS Stodles o n Acetylcholine Sensor and Its Analytical Applicatiott ~ o n the lnhllhdtioft o f Cholinestorue. Bk~ensors 1990, 3:461-472 TROJANOmCZM, M A T S ~ W, PODSL~DLAM: Enzyme • Entrapped Polypyrrole Modified Electrode for flow-Injection Determimu.tion o f Glucose. Btosenso~ Bme/ean~tcs 1990, 9:149-156 [7]. TSENHY, WANGSJ, ROE BA. GREENSS DNA Sequcmtc¢ o f • S~ltaonelts-Sl~'ctfic EDNAFr~gtaent and t h e use o f Oligonucleotide P r o 6 ~ for Salmonells Detection. Appl Mmmbiol ~ 1991, 35:339-347 URBANG, ~ E R H, JACI-RMOWICZA, KOHLF, KLWrI~R H, Ot£A~TUGF, GO/SEaP, ~ a F, S C a R T, MANN-BUXBAUME The Construction o f Mlcrocalot4meudc Bioeensors by use o f High Resolution Thin-film Thermistors. Bt0aensors 1991, 6:275-280 VENKIZWP, MANGANC, SIDIXQIl~7. ~ e f l c Determin-tion o f Mkslinc E h ~ p h a t a s e Activity o n hydrolytic Cle=vaSe o f t h e P-~ Bond i n MonofluofophOslphlte Jmd Fluogide Ion-Selective mectrode. Aria/B/odwm 1990, 191.127-132 WANGJ. E l ¢ c t r t m ~ i s mad Biosem~ogs. Aria/ 1991, 63.R235-R237 WANGJ, WU LH, ~ S, SANCHEZJ Tissue nloelectrode fog IF,.limli~tJn8 Protein interferences..,O~alO ~ n 1991, 63398-4OO. WATANABEE, TAKAGIM, TAK~IS, HO6m M, CAO SG Developmettt o f Biooe~sors for t h e Simultmmous D e t e r m i n t t l o n o f Suortme and G l u c o ~ , latctom~ a n d GlucOse, and Starch and Glucose. Btotecbnol Btoeng 1991, 3899-103. WmTAKERJE, HAUGLANDRP, PRENDERCO~TFG: Spectr•l mind PhotophyMc81 studies o f ~ [ c ] mmthene Dyes - Dual Emission PH Sensors. An,u/B~.bem 1991, 194330-344, Wm,t~R I, LAPmOTN Electricaliy ~ Glutathlone lteducmse - • Siocamlyst for the Photochemical Reduction o f G l u t a t h i o n e . / A m ~era Soc 1991, 113:3625-3626. WORSFOLDpJ, WmrES~DEIRC, PFEWFERI-W,WM.OHOFFH. An Automated Spectrophotometrlc Flow-injection Procedure for the Determimttion Of CeUulmm Activity i n Bioresctor Prepa~tions. J B/oteOM~ 1990, 14.81--88 XE X, KUANSS, GURB.M~TGG. A Simplified Fructose BIoeeasor. B~sen.~rs 1991, 6.49-54 YABt~ S, MmrrANIF, ASm M' ~i~p~watlon and Characterization o f a n Electroconductive Membrane ConUdnin8 Glutamate Dehydrosenmm , NADP, and Medl•tof. Bt~en.~ors 1991, 6..311-316 YAOT, KOKAYASE~N. WASAT: ~ p G l ' o m e t g l ¢ FlowWE0 illJ(:ctlotl ~ I N ~ I S Of L..C~UtlIWdttCUs~tllt aU I m m ~ Enzyme leaction-Ampli.fication by Subs•rote a e c y d i n ~ E t ~ : m a n a 0 ~ 199o, 2.563-566 [331. YAO T, KOBAYASmN, W~.~ T: Ampta'ometric Plow. • Injection System w i t h am l m m o b l l i z ~ l Enzyme fog the ~li~hl~ Selective Detect/on o f Phosphate aml On-Line AmplHlcation by Sulmtmte RecydinS. A n d O~'ra Ac~ 199o, 238.339-343. [44]. ZA~EnJ~L MARIOUJ, K~ANA T. El¢¢trochemi~l Detector for Liquid Chromatolltaphic Determination o f C m b o h y d r a t ~ . An•/Gbem 1991, 63.649-653 ZHAOS, LENNOXRB. Pyfroloquinolinequinmae Enzyme l~ectrode BaNd o n the Coupling o f Methaool D e h y d t o l e n ~ e to • Tetrathhtfulvsdene Tetmcymtoquinodimeth~me Electrode. Ana/Oxom 1991, 63:1174-1178. ZHIJ C, HIEFOEGM: IFet~iblllty o f Usin~ Liquid Crystals for the Development o f Molecularly Selectim~ Flbor-optic Chemical Sensors. An•/G~ra 1990, 62:2079-20~A. ZVIMANM, TI TEN H. lFormmtio~ o f a b l l • y ~ Lil~d Membrane o n R i # d Supports, an Approach to BLM-IMtsed Blosellso~. Bu~ensors 1991, 637-42

Fermentation monitoring Review: (pp 40-44) B~ •

WL S[~vt,~NRW. RoliinS-sphore Viscometor for I n $ ~ Monitoring o f Shske-fl~k l%'rmenmtions. Enzyme M/crob Tec.bn~ 1990, 12 818-823 [10].

Analytical biotechnolosy Carbohydrate analysis Protein isolation BURLAGERS, SAYLERGS, LARIMERF M o u l t o r ~ o f OO Natphthalene ~ m by Binlumlnescence With na/~lux Trunscriptional Fusions. J Bac2eno/ 1990, 172.4749-4757 [12]. CAVEAT•AG, MAYASDM, GE ZH, CAmSJB- N o n i n ~ i v c Method for Mo~ltorinB Ethanol i n Fermentation Processes Usin8 Fiber-Optic Near-infrared Spectroscopy. Ana/~aem 1950, 62 1977-1982 END• H, SODE K, KARtmE I, MURAMATSUH. On-IJne M o u l t o f h ~ o f the Vi~eslty in Dextrmt t~rmenuulon Usin8 Ptesodectric Quartz Crystal. B~otecl:mol Bioeng 1990, 36..636641 FAmnm:m-mep, GEORGEWO, ~ JM Whey" Permen~ - On-IJne Anal~is o f lacto~e and Lactic Acid by F r m Spectro~:opy. ~ M/erda Bl~...bno/1991, 35 30i-305 E, B A ~ A D, GARCIAJl~ QLmwlx~OPc Microbial • S¢~tfJof for l l ~ d l l i n * U S ~ • Recombimmt Strain o f Emff~e'&ffa~ ~ En~/rne Microb redonol

1990, 12~2--646. [5]. IAJ, HUMPHREYAE. Use o f Fluorometry for Monitoring • • and Con~oi o f • B l o l ~ m m ~ r . B ~ Bmeng 1991, 37.104~1049 [16]. L~NDELLPI, HALL1~WU T, COONEYCI~ Coml~rlaon of immonOaMay and an ~ for Monitoring Productivity i n Mammalian Cell Blore•¢tors. B/otechno/Techn~/ues 1991, 5 187-192. 117]. ~ M H, BI~OBJ~R M, OST~IIOF B, MOKS T A o o Completely A ~ System f~r Online Moultoring o f the Production o f a Growth l / : t o r Seereted Durinl~ Fetmcntmion

3&10~-1062. !181. PARgJ, KIM H, A New Binmm~or fog Specific • Determination o f Gluceee or Fructose Usin8 an O x i ~ o f Z1mtomoN~mM o & ~ . B / ~ b n o / B/0en~ 1990, 36-744-749. [6]. PARKJ, RO H, KIMH: A N e w Blot~mto~ for Specific • Determitmtion o f Sucrose Usin8 an Oxldoreducmse Of ZymommmmsMob~z and ~ . BtoteOM'~l Btoeng 1991, 38'217-223 [7]. Roos JW, ~ M& Control o f An ~ C o H • Mixed Culture Via A f ~ t iW Bin,din,,, B/otecbno/ B~oeng i99i, 38:380-3~ [19]. SIANOS~ M ~ g NADH Fluore*¢e~¢e and ee ox~eo upta~ ~ of nybridom~ O a l t u ~ to Sul~cate Pulse and Step Changes. B~eoM~Bmeng 1991, 37141-159. [151. SwrI~EN~&UMMS, GmALDOGO~mZE, HICKEYRE. Monitorln8 of the Anmetobic Mcthane Fermentmion Process [Review]. Enzyme M/crab Tecbno/i990, 12 722-730 WATANABEE, TAKAGIM, TAI~I S, HOSI~M, SHU-Gta o o C Developm•mt o f Blo~msot~ for t h e Simultaneous Determination o f Sucrose ami Glucose. Lsctcee a n d Glucose, and Starch and Glucose. B/otec:bno/B/oe~ 1991, 38.'99-103. [3].

Carbohydrate analysis Review: (pp 45-48) Atmme'wsRW, FaNGRM: Selection of Potentials for Pula~l Amperomeu'le Detection o f CLrbohsMlraum at Gold Electrodes. Anad Ok-,m 1990, 62:2130-2i34. BUEEL BOYLENJ, Z/-LM~LB, D~IACOURTEA. FILLITHM. O~timlw~tl~n o f ~R AIcllt~ Blue Dot-Blot Assay for the Detection o f G l y c 0 e m i n o s l y c a m and P r o ~ . Ana/B/0dx-m 1991, 195 238-242 CmEN CH, W~ YH, SHAWJF: Immobilized Enzyme System for Determination o f Slalic Acid i n Setmm or Urine. Enzyme Microb Techno11991. 13:45-52. DE WAM~DP, KOOREVAARA. KA~RLINGJP, VLIEGENTHART • JF. Structore Determination by 1 H NMR o f (Sulfmt~) SislyIIm~! N-ilnk~l Csrl~hydesm O u i n s Released from Porcine

rnyro#obmin by t~/de-N~-(N-acetyi-~~lu¢osminyl)lsp•g~¢ ~ - F . J B~o/Okora 199i, 266.4237-4243. [25]. EDGECJ, RADEMACI~RTW, WORMMDMR, PAREKHRB, O• BUTrE~S1"13,WINGDR, I~t~K RK Fast Sequencing of O ~ : the Reagent Army A n a i ~ i s B~"tlhod. Pro~ Natl Acad S~i USA 1992, i n ~ :

1451. K~MB, CHAGS, Meammaoev ME- H ~ t ~ z u m ~ e t~.k..d Blndin8 ,¢amay for studying the interaction o f Lectins with Carbohydrates and Glycoproteim. Ana/Cbem 1990, 62 2663-2668 LEEYC' l t l l # - l ~ f f o r m ~ c e AulowExdumBe Chromatography for Carbohyd~te .Analysis [Review[. Aria/B/oc,bem 1990,189.151-162 LIUjP, SrtmOTAO, WIESLERD, NOVOTNYM- U l ~ l t J v e o o Fluot,'mmetric Detection of Cat~ohyd~ttes as ~tlv~ in Mixtures ~ t e d by c ~ m a ~

]F,lectrophor~sla. Proc Natl Acad Sct USA 1991, 88.23o2-23o6 [301. MERRYAH, BRUCEJ. BIGGEC, IOANN~ESK Autommt~! o o Simultaneous Relelse o f Intact and u n ~ d u c e d N- attd O-linked M from Giycoproteins. Btoc.bem Soc Tram 1992, 20-91S [24]. MLrVERB, HAmENT, NUTED, AmERSHE~,IP, DARWLL& YORK W, SELLERSJ, Identification o f the H-I-NMR S p e c t r a o f Complex OELBos~charld~ with Artificial Neural Ntqtworfm. Sc/en~ 1991, 251:542-544 MOCKK~ DAVEYM, COq~LLJS The Analysis of o o Umlerlvatlaed O H l ~ c ~ d e s by Mstrixu s ~ t e d Lsser D e s o t l ~ o n Mass Spectrometry. Btodaem Btopl~s Res Commun 1991, 1"/'?:644-651 [9]. NASLUNDB, Am~R P, BOLINImRJ, HALIANDERL, LUNDIN & GI~ Drama-mitre•ion in S~mmplesTaken by ~ l a by p e r o ~ lnmlM! C~l~nmin~. A ~ a ~ / B ~ 1991, 192.237-242. OtSSON L, MAimmmusCF. 19ete,.mi,~mtion of ~ d ~ in C,elluloek: H r d r u l y m t ~ Usln8 Immobfllzed l~mmmse Oxldese i n a Comhtuous A m ~ e t r i c ~ . Aria/ 1990, 62:2688-2691. SPELLMANM~V:Cau'bo~0ydt~t~ ~ o n of Recombinant Glycoproteins o f Ehmrmtu:euticul Intermit [Editot~d1. Aria/O~ra 1990, 62 1714-1722 ST/d~ B, STEUPM, ~ M, HIla~NKa/v~F. haul,/t~ of Neutral O ~ by MatrixAmafmed Lamer D ~ o r p t i o n - l o u l n t i o n Mam~ St~'cU'omet~y. Aria/¢~era 1991, 63:1463--1466. TOGA~ DW, POt~EN BJ, BATALAOCW, ROLLSWK Selml'ution o f CArbohydrates a n d C t r b o h y d r l t e b y HELC with C a t i o n - ~ = ~ COlUmmt at HlSh PH. Btotechng/ues i991, 10~50-655. Tmrrnm v, ~xTu~.~ E M~Z ~- Foptide-u 4 -(U~u~-trl• ~lucce~inyD~ ~ • c*,,-ot ~.hmse GIycmm with l~coee Attached ctl-3 to t h e ASlmm~lne-linked N-acetylglucommine leaidue. EurJBiodaem 1991, 199:647~52 [19]. ZADEIIJIM, MANOLIJ, KI~VANAT ~cta-odum~l~ll Detector for Liquid Chromatoflrtphic De••rumination of Cattm~ydmte,. Arud Gbem 1991, 63.649-653.

Isolation and analysis of proteins and

pep•ides

Related review: (pp 4 9 - 5 4 )

Peptide screening

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Analytical biotechnology Assay systems DEARS, STADENR. A ~qU~tl~N~ Assembly and Editing ~ , o p t m for E ~ c i e n t Ms~t~ement of Large Projects. Nuc/e~ .~sd$ Re$1991, 19:3907-3911 D~USmRC. A Qmmtimtive Dot-Blot Immunommsy for i n t e l g s l M e m b r ~ e P r o t e i n s . Preparstion of I~mcrutic P l a s m Memlmmes Cot~rsin~no Apical and b s o l a t e r a l DomsUm. Am*/BkT-/mm 1991, 192-1-5 EP, CHmSlOPOUL~T~ Europium Chelate i n Time-Resolved H u o r a c e n c e l m m ~ trod DNA Hybridlaation Aumys. Aria/Oaem 1990, 62~1149 DmA~ELU3C& I n t o r l e u k ~ - I mtd Imerleukin-1 • /knmllot~m. B/ood 1991, 77 1627-1652. [8]. DOU I. K~ULLIS Deternflnaflon o f Aromatic and Sulfur-Con~lnino Amhw) Acids, INeptid~, and ~ L~Jn8 msh-i~ffoemonce Uquid O m m u . o t t r a # y with Photolytic Electr~chemical Detection. Aria/~bem 1990, 62.2599-2606 EBELINGF ETAL. ~ - ~ q ~ t ~ t i o n mIBA to ConOA~ D i s ~ z a i ~ Of HCV Infection Better]. Lancet 1991, 337.912. ELm~ L, KULAMK HADASE, KAT(mmSKn~tT~E. Partition o f Free and Monodomd-Antibody-Bomad Hortmntdish Peroxidmm in • Two-Phase Aqueons Polymer System - Novel Procedure for t h e D e t e r m i m ~ o n o f the Aplmrent B i n d ~ g Conmmnt o f Monodonal Antibody to Horseradish Pt~oxlda~. Aria/B/odJem 1991, 192:74--'77 ENGLEBEIKTSI ANDOTI~I~. ~ ¢ e foe ~ t Effects o f Soluble TNF Receptors o n Vsttous M~ments in Humsm Blofogtc~l Fluidg [letter]. Lancet 1991, 338515. ERg~dKUT, Z~NNOS, 1NOUYES' BIoJnmln~'Jl¢ont l m m ~ Using • Mommaeri¢ Pab'Photoprotetn ~ . q u o r m c o n l u s s t e . Bm~em B/q0bys Res Commun 1991, 174:1331-1336. FERNANDEZE, KOPC~CK~: Q ~ t i t l t t l v e D~tegmh~flo~ o f Growth Hormone by lmmunobiotthag. Ana/ Btm6era 1990, 191 268-271 FEVE~U~OM, RONEK~RC, LAUPSA. TAVARESl~ DENORONHAFChastJctetizaflon o f Two M o n o d o m d A n ~ e s A ~ n * t Feline Immonodeflciency v l r w Gag Gene Products a n d Their ~ l i c a t i o n in an A/MM~ to ]E~d~te Nextrmll~dna=Atttll~h~ Activity. J Gen Vwo/1991, 72:617-622 F~L M, MEBAALVAREZ1~ ZOr~ATOF, VOLPEP, STEFAN1E. A n t l ~ D d ~ ill P g o b ~ fog L ~ a d ~.mtln~ of Single Sarcoplasmk Reticuinm Ca2 + -Release Channels. BtocbemJ 1991, 2'73,:449--457. F~DL~¥J, EuoPOtv.OSE. Three-Dimensional Modelling • o f G Protein-tink~l Receptors. Trends Pbarraacol Set 1990, 11:492-499 [9]. GASCONNMJ, SIX HI~ U n l ~ n ~ Vaccine Otrrler L l l m ~ o m a that ~ T- Dependent Help to Weak AattlSemm. J Immuno11991, 146.3697-3702 GATANAGAT, H~ANGCD, KO~ W, CAPPUCC~IF, LUCC1 • JA, JF~s EW, LEL~ZR, TOVaCHJ, YAMAMOTORS, GRANGERG~ Pugi~¢~tion and C]J~lltgll¢'qtefl~l¢lttion of an I n h H t o g (Soluble Tumor Necrosis Psctor Receptor) for Tumor Necrosis IPactor mad L~mphotoxin Obtained from Serum L q t r g f l l ~ o f Human Camcer ]Patients. Pr0~ Natl Acad Set U S A 1990, ff7:8781-8784. [7]. GELEANDMS. Computer P r e d l c t ~ n o f the Exon-intron Structure o f Mammalian Pre-mlqNAs. Nude~ Aods Rm 1950, 18:5865-5869 GIlaDI E, SP~I)ELER: Simple IJmmlnOnlCttJc AmMly to Detect IRaomphoinmltol-llnlu'd Receptor E x p r e ~ i o n in Xonoptm O o c ~ . B~m~:*s 1991, 10-744-747 GOO~C~mDJ, V~S~FANATHAJl~ A Novel Atomy for DNA Llgase. Ntw2e/¢Acu/s Res 1991, 19.3745. GRWFrrHSD/~ BESTDJ, JE~QUELSG The ~ of Mlcxoott'~tni~u for use as Models of Mammalian Drug Metabolism. ~ M~ra~o/ B/otedmo/199t, 35:373-381 GROSSJ~ ENDEgSSTEPb~N$L, H~F~LIN WF: An A u ~ t e d Filtration Assay for Protein Klnsse-C ~ p m d s . AnalBiockem 1991, 193 149-154 GULTYAEVAP The COlml~tter Sl~aulatlon o f RNA ]FoIdlno ]hB~IIH~ Pscudokflot ]FOt'lBagfloIB.Nude~ Acak/sRes 1991, 19 2489-2493 GUTI~mJC, MANESM, BASSKA, LEE EJ, NEEDLEMANSW Qumttitatfon o f the Pals Gene Product in Leukemic Blast Cells Usin8 Enzymatic $ ~ . , . , n ~ BmtecJ~nMnues1990, 9:212 HAGEDS. I m m ~ . Ana/Gbem 1991, 63.R206-R209 HAGEDS, KAO PC' High-Performance Immonoaflinlty C h ~ h y ~ Chemllumlnescent Detection in the Automation o f • Parathyroid H o r m o n e Sandwich I m m o n c m ~ m W . Anal C~em 1991, 63:586~595 HA~L~ RE, MOND~ D, COLE~.NK P~XASHO ~mmunocytochemlcal Localization o f

C h l o t • m p h e n i c o l Acetylmmsferase as a SingleCell Marker o f Tt'a~fectod and Trmm~=nic Cells. B/~ec/m/ques 1991, 10-304-306, HAUNM, WASIS: Blotinylated Antibodies Boond to Streptavidin Beads - • verastile Solid Matrix for Immmaomma~. Anat Btochem 19~, 191.337-342 HENDERSONL RAOAG, HOWARDJ An l m m u n o a m n l t y Immobilized Enzyme A ~ t y for Neomycin Wac~phommdetmm-ll in Crude Cell Extracts. Ana/B/odx,m 1991, 194:64-68. l-lt~v v, L~ JN, ANDP.~e Jl> Spatially Resolved Detection o f Antibody-antlSen gescOon on Solld/Hquid I n ~ Using Total Internal Itmfle~tion Excited A n t ~ n F l u m c e and ~-coupled Device Detection. Bmsensors 1990, 5:291-302. HOGGPJ, JACKSONCM, WINZORDJ. Use o f Qsumtitative AfBaflty C h r o m a t o s r t ~ h y for ~ g H l ~ - A m n i t y Interactions. Binding o f Hepm'ln t o Antith.fotabtn-III. Anal Bu~chem 1991, 192,303-311. HOMERKA, BEIGHTOND l ~ i u ~ c ~ t i o n o f la~cterlal P r o m Activity Usin8 ~luorescein i~flMocyanato-labeled Protehm as Subetmtes. M B/0~em 1950, 191.133-137. HYIANDLJ, DAYTONBD, MOOREM~ SHUAY~ HEY~Jl~ MEEK T~. A ik~llometric &usy for HIV-I Protoase. Aria/ B/ocbem 1990, 188:408-415. LMASta~T, NAKA~WAH, OKAZa~T, Isrlm~m N Enzyme l m m ~ o f hmulin by ~malconductor Laser Fluoetmaetry [letteg]. Aria/OJem 1990, 62 2404-2405 JAIJtflA~ENM, METSOJ, KOSK~ENP, EHNHOLMC: O t a t t c t e H z m l o n o f the Enzyme Activityof H . m ~ n P l a s m Lipoproteln(a) Using Synthetic Peptide Sulmtmtes. B ~ r a J 1991, 274.49~-496 JE~ WT: The Pyruvate Kimum-Coupled A ~ t y for ATPases - • C r l t i a d Anelysis. Anal B/odaem 1991, 194.136-139 JHA PI~ NAKH/dB, SPaDHARP, TALWARGP, HASNA~ SE: iqrefly ILucifet•tm, ~ t h e ~ l ~ - d t o Very m l h Levels i n Caterpmars infected w i t h • l e c o m b i n s m Baculovirus, can Also be used t s an ERielent Reporter EnZyme Iuvivo. FEBSLeft 1990, 274.23--26. JULLANOL CHAC~JR, H~ATAW, C~MONAE, SOCUPmAM, O L ~ A ES, O ~ EB, CAMARGOACM.A Amity for EndooUsopepfldase • Based o n the CkavaSe o f IRuOrolWnic Substrme Structurally i l ~ l t ~ to P~ndkephmlln, B ~ o m BIq0/TysRe~ Commun 1990, 173647--652. Kma~SON I~ Glycobtology: a Growing Field f~e Drug • ~ TrendsPharmao31S~t1991, 12265-272 [~;]. KESSLERMJ: New Instrumentation TechnolosY: o o Amdyse 96 R • d i n a c t t ~ Samplea $imulttmeously. Btoteclmolo~ Int 1991, 251-256. [12]. KHAL~O~, ZUREKTF. PEPEC, GENGER~ HUFFDG, COLEMANC, HANNAC, HU K MACKOW1ACKJ, BENNETT1~Detection A i p p ~ t t ~ for Multiple H e C e ~ s e n e o ~ CheDl~um |mU~lcence I m m ~ Conftgug~tiomJ. Ana/B/oc.bem 1991, 196.61-~. K~m ~J, s~ogr K~ SEnXE~ RJ. A ~ t y for Detection and Enumeration o f Genetic*ally t~n#neered M l ~ m s Which Is Rased o n the Activity of a D e - - t e d 2,4-1Mchlorophenoxyacetate MonoomyBenat~e. ~ l Environ Microbto11991, ~7:17~O-1792. RL, B~ql-mRST, HALSEYN, Bo0tos R, ~ R E MD, QUINNTC: IEvahmtion of I ~ e Imumuao~umy~ fog Antibody to H n m . n T-lymphotropic Viruses Type f i l l . Lancet 1991, 337:30-32 KORCGm~CK1B, CHAIND, KRE~tANT, SHAL~ELS Eazymmic AsMy for Vltronectin Based o n Its Selective P h m p h o r y l a t i o n by Protein rdm~e-~. Aria/B/odx, m 1950, 18&288-294 KRAMERP, SCI-~MIDK ]Flow inJectlma lmmtmomlsly~is (IPlIA) ~ a New lmmonmumay Format for the Detmmmtomtion o f Pestidd¢~ in Water. Bmsensors 1991, 6.,239-244. KRCHNAKV, VAGNERJ, NOVAKJ. SUCHANKOVA& ROOBAL J. A General ~ u r e for Evldu•tion o f lmmtmoloKi~d Relevance o f Synthetic Peptides - Peptides S3qtthesized on Paper in Eazymellnlk~t I m m u n 0 8 0 1 t ~ t ~ . Aria/B~c~em 1990, 189:80-83 KRCI~NAKV, VAGNERJ, SUCHANKOVA~ KRCMA~M, RWrEROVA L v o ~ V. Synthetic Peptides Derived from l ~ Resion o f H , , ~ - ~ Papmomsvirus Type16 nK~l as Antigens in EIJSA. J Gen V#ro/1990, 71:2719-2724 I, GONZALEZM, ROY G, VILLARLM, GONZALEZPORQUE P. ~ p t l o n o f an Enzyme-l,!nk,-~! l m m u n m o t b e n t AMay for the Detection o f Protein T y r m i n e Kimme. Ana/Bum0em 1991, 192-257-261 LEJEUNER, TmrNus L, Goumz F, FEmKENNEF, CLOUXJL HENNEN G: Subfemtomole Enzyme Immun0assay

for Human Growth Hormone Ushlg Aninity O m ' o m a t o g r ~ h y a n d Enzyme Amplified Dctcodott. Anal Btochem 1990, 189 217-222. L~ONA ETA/.: Second-generation RIBA to Confirm Diggnosis o f HCV ~ o n [lettor]. Lancet 1991, 337:912. LEm~ESNB, NOCKAKH, COLESK QIO FH, S ~ & ASHMAN LK. BES~mRP Monoclonal Antibody-YBS.B8 Identifies the Humutn C-Kit Protein Product. B~od 1991, 77.1876-1883 JY, CHPdSTENSENBM, TRACYJW Electgt)chemlcal Determ/mation o f IMphcmoi-Oxidg~ Activity Using H l f f J h . ~ Liquid ~ t o g r a p h y . AnalBtod~om 1990, 190:354-359 QL YAMAMOTON, g~otm & MOmSAWAS: An A s u y Procedure for Solubilized Thyroid Hormone Receptor - use o f Llpldex. Aria/BJ~/x, rn 1991, 192:138--141 lau HJ, Yu JC. BL,~ORADS, GWENSRS, WILSONGS: n o w InJectiOB Solid-lqlm~ C h e m ~ n m | ~ o n t Immanno•~tty Usitt8 8 M e m l H ~ t Q e - ~ Ig~l~tor. Ana/O~ra 1991, 6 3 , 6 ~ o 6 9 12~ONARTR. NAF D, BROWNINGH, WEISSMAm~C A No~el, Qumttath~ Bio~mty for Type I Interferon UsLt~g • recombinant Indicator Cell Line. B/otec/,no/o~ 1990, sa263-1267. LOYMD ETAL. I l i A Typlmqi b y Double ALMS Oetterl. Lancet 1991, 33565. LOCASCIOBROWNL PLANT AL, HORVATH V, DURST RA. Llpceome Plow Injection I m m ~ . Implications for Semltivity, Dynamic nanlle, and Antibody Rel~neration. Area Omn 1990, 62.2587-2593 LONGLEYMJ, MOSBAUGHDW' ~ o n of DNA Metabolizing Enzymes insitu Following Polyscrylamlde Gel mectrophoresis. Bur2aemtmy 1991, 30:2655-2664. MACLEANAI, BACHASLG. H o m o ~ ' n e o u s Enzyme l m m u n m m m y for Llpoic A d d Based on the Pyrm~te Dehydrollemme Complex - • Model for an Aasay Using • Conjugate w i t h One ~Jm.d Per Subtmit. Ana/B~O~rn 1991, 195-303-307 MALENCmDA, ZHAOZH, ANDERSONS~ P h o o p h o g y ~ Klname - Development o f • Continuolm l~uorometrtc Amay for the Detetmbmtion o f Catalytic Activity. B ~ B i ~ / s Res Commun 1991, 174 344-350 MAN~ ~ GROSSEF FaSt Isolation o f Recomb~mmt by Antibody s c r e e n ~ . B ~ e ~ s 1991,10:154 MCGOWANJI~ KESSLERSP, ANDERSONDC, GALLOWAYDR. Immtmochemlcal ~ o f l~eudomommA e r u s i n m s leatotoxin-A - ~ of the 111~26 Dct~'mlnant. J B/o/OJera 1991, 266.4911-4916. DL SOeOLTZJS: A Molecular Model for Singlet Slnglet E n e t i y Ttmmfer of Monovalent L l p n d Receptor Intetae~on~. Btotec.,br~ Bloeng 1991, 37.1066-1075 ~ C ~ L S, COURSEAUX& ~QUEL C, BERNARDONJM, ~ SrmooT B, THACI~RSM, REIC~RTU. De~terminmion o f g e t i n o t d Activity by an Enzyme-Unked l m m u n a e o r b e n t Assay. Ana/ B/ocbem 1991, 192.232-236 MIMMSL ~rAL: Spe¢ifidty o f Anti-HCV ~ Aascased by Rescthd W to Three I m m u n o d o m i m m t HCV ltesions Better]. Lancet ~990, 336.1590. /em,~CK AA, EmF.~B£RLE, MCILEEJA, DOLE~C~EIL MILLERMJ. Blcmasay for Slderophore Utilization by CsndldaMbicans. Arm/Btodx, m 1991, 194:223-229 MITCrmLLSW, MBOUPS, MINGLEJ, SAMBED, TUKEIP, MB~ENGE N~AMONGOJ, MtmARAKO-~ SANKALEJ'L HANSONDS, Qtm~N TC lqeld IN~tluatlon o f <ertmti~e lllV Testin 8 Strategy w i t h • ~ Immunobladi~g Assay ond a n ABglutinmton/mssy./ancet ~991, 337 1328-1330 M o ~ N, COLECA, TAMM, GOLDSTE~L NOW~S~aRC Application of a Thermel~-Reverslble Polymer. Antibody Conjugate i n • Novel Membrane-B•sed lmmtllRO•N~ty. B ~ B ~ y $ Re$ Commun 1990, 172652-660. MOOREMAS:Hsemopoletlc Growth Factor • o lntemtctiotm: In Vh'roand i n l,'k,o P r e d l ~ c a l Evahmtion. Cancer Sum 1990. 9 7-80. [2]. MORTONRC, DIAMAN~EP $tt~-pta~tdln.B~ed Macromolecular Complex Labeled with a E u r t ~ l u m Chelator Suitable for Time-Rasohred Flu~ce Im~r'unO~sSay AppH~ttio~s. Anal Owra 1990, 62.1841-1845 MOSMANNT~ SCHUMACr~SJH, b~O~ENTE~ODF, LEVERAHJ, MOOREKW, BONDMW- Isolation o f Monoclonal Antibodies Specific for IL-4, EL-~, IL-6, and a New Th2-Speclfic Cytokine (ID10), Cytokine Synthesis Inhibitory Factor, by Using • Solid Phase iladlo[mmono~lm~rbem Amay. ] lmmuna 1990, 145.2938-2945 MURRAYJl, DfNH"IT, TRUETrAP, KENNERLYD& lsoLttion and Enzymic A s h y o f ChoBne and

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Analytical biotechnolosy

Electrophoresis

Phc~phoclmUne Present i n CeU Extracts w i t h Picomole SemJ|tivtty. Biocbem f 1990, 270:63-68. NADERIS, MELCHIORDL A Firefly Ludfet'tSe As~tty for Sulza~aomolar Concentratiotm o f Amphilmthlc Sulmtances. Anal B~Amm 1990, 19~.304-308 N, HASm~OTOFL MA~SONAC,AT. I m m ~ Method for the DetermJmmtlon of lmmtmoglolmlln4; Using Bacterial Magnetic Pro'tides. Ana/ax, m 1991, 63 268-272 NETLERWJ: O~efcomlna Limits o f Immu~o~o~jUlpttt~

[letterl. ~ t e c ~ n o ~ ~991,958O. NICKERSOND/~ KAISERI~ LAPPENS, STEWARTJ. HOOD l~ LANDEGRENU' A I I l ~ l t ~ ' ~ DNA IMalgnostlcs Using

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B2]. SHEERDG, YAMANEDIf~ HAWKEDH. YUANPM" The use o f Micropreparatt~ E i e c t r o p h o r ~ l s o f Prtnein/peptide l m l a t i n m for Primary Structure Determinttions. B~techmques 1990, 9.486 SHUNONGy, WOtSKAt~SMM, CA~ JR. Gel Eiectaophoresls o f Reacting Mmcromolecules l~tte-Limited S ~ l f - ~ t i o n . Ana/Bt~J~om 1991, 196 192-198

SMITHRD, UI~ETHHR, BARINAGACJ, EDMOND6CG • l m t r u m e n m t i o n for Hish-lmrfotmance Capillary t n e c t r o p h o r ~ - t m m s Spectrometry. J (~0ma~gr 1991, 559:197-208 [47]. STREGEM, LAGUK SClmM~tiO~to f DNA Restriction Frlql~enta by CapUlasy Flectrophoresls Using Coated ~ Silica Capillaries. Aria/Gbera 1991, 63 1233-1236 STREGEM, LAGU/LSepiIP•tloo o f DNA ltlF~trlction • Fragmenta by Caplllsry Electrophoresls Using Coeted Fused Silica CapJJlarle~J. A n d O~m 1991, 63:1233-1236. |33]. TAKAHASHIN, HIROSEM Determination o f Suilhydryl Groulm a n d lMsulfide Bonds in • Protein by P O ~ Gel F l e ~ r o p h o t ' ~ i s . Ana/Btodaem 1990,188.359-365 TOWNSJ ~ REGNEERFE Polyethylt'nt'tmime-bond~'~l •• ~ i n the Separation o f Protettm by Capillary Electrophoresls. J Ort~aatogr 1990, 516 69-78. [l~q. TOWNSJK, REGNIERFE' C l p l l l l r y E ~ u r o p h o f t ' f l ¢ o o Sepecatiom of Proteina Using Nonlemlc S ~ t Coathags. Amd (~ora 1991, 63.1126-1132.

[101. X~CE~rr A. HERTZD, P~Tr C, K~aX C, OnEm~ 1, MANtmLJL Abnormal Pattern Detected tn l~m~le-X Patlema

by ~t~Mm-aeM Get m e c t ~ h o r e ~

0etter].

Nature 1991, 349624-626 WANG'IS, AmZNJI-L HUm CW, ~ C K I ~ NamoliterScale Multtreflection Cell for Mmorptinn Detection i n Capillary Electrophoresls. A n d CT~m 1991, 63:1372-1376.

WELLSK, COm~GL~ JS, Detectha8 Proteins Conudnin8 3,4-Dlhydroxyphe~yhdanlne by Silver Sm,n,no of P o l y ~ d e Gels. Aria/B/0c,bem 1991, 194:237-242. WHEATTE, YOUNGPM, ASTEPHENNE: Uae o f Capillary • Eiectrophoresis for the Detection o f Sln#eresidue Sulmtitutiom ha PeptMe Mapping. J Lu/ ~oma~0gr 1991, 14:967-996 [2]. w ~ o e o m c z JE, C o m ~ JC: Seperation o f Cationic • ProteLm Via C h a s ~ g e v e m d In C a p i b r y Electrophor~is. E/ectr0~xwe~ 1990, 11 769-773 [131. Zsu M, ROt~GUEZR, I~h~SEND, W~Sa T' Capillary • E]e~if~q.horesis o f Proteins Under Allmline Conditions. J ¢~'omatogr 1990, 516.1123-1131, [15]. ZHUM, RODmGUEZR, WE~mT- O p t l m l t l n o S ~ t ~ t t i o n • Parameters ha Capillary lsoeletric Focusin8. y ~x~na~0gr 1991, 5~9:479-488 [22].

In vivo NMR and other non-invasive

techniques ADAMSSR, HAROOrONIANAT, BUECI-n.ERYJ, TAYLORSS, TSlEN RY Finoreacence Batio ~ o f Cyclic AMP i n $1nsle Cells [letter]. Nature 1991, 349..694-696 BERNDTKW, GIPt'CZYNS~I, IAKOW1C2JR. A Frequency-Domain Flnorometer with Internal M I ~ Plate PhotomultipHeg Croe~ ~tion. Ana/Btocbem 1991, 192:131-137 BOCKMOBIUSI, BRUNEM, WITTINGHOFER.~ ZJMMERMANN H, LEBERMANl~ DAUVERGNEMT, ZIM?~2RMANN S, BRANO~mmRB, RO6CHP: id~atificttiott o f V~lne/Leucine/lsoleucine and Thrz~/ALmiue/Giycine Proton-Spin ~mtems o f Fachericlflx- Coil Adenylste Klmme by Selective Dcutcgation and Suiecttv~ Protonation. Btodaera J 1991, 273:311--316. BRIASCOC~ KARELSF, ROBERTSONCl~ l)J~l~dO~dtl 1Jmimtions o f ImmobiUzed Facherichia-CoU i n Hollow-Fiber ~ - Influettce o n P-31 NMR Spectgoecopy. Bto~xbno/B/oeng 1990, 36:~7-901 BRIASCOC~ ROSSD.~ ROBERTSONCl~ A HoUow-FJbeg Reactor Design for NMR studies o f Microbial Cells. BIotechnol B ~ n g 1990, 36 879-886, CLOREGM, GRONENBORNAM: StguctugtO o f lalrSeg Proteins i n Solution - 3-1Mmetmional and 4 Dimensional H e t e r o n u d e s r NM]t Spectroecopy. Scm~e 1991, 252.1390-1399. COSSARJD, BLA)~-COLEMANBC, RAMSAYC, ATK]NSONT& Osctlhametric Instrument for the Nem-Lmm~ldve Detection o f Low-level Mlcrobl~ Activity. Part 2t Growth Clmwactertstics, Detection Umita and Impedimetrtc AmmSm. Bt~emors 1990, 5 273-290 DJABAUM, NGUYENC, BIUNNOI, OOSTRABA. MATTE!MG, IK~DA.,rE,JORDANBP~ 1JtSeg MlcgodJasegtinn of the F r a m e X ~ o n - l d e m l n c a t i n n of Coemld Clones and o f Commrved Sequences in This Reston. Genomw.#1991, 10.1053-1060 FEJZOJ, KREZELAM. ~STLER~g]~[, MACURAS, ]~LARKI~YJL Beflnemeat o f the NMR Solution Structure o f • Protein t o Remove Distortions/MdsinB from Neglect o f Internal Motion. Bto¢_.bemmtry1991, 30 3807~3811

80

A n a l y t i c a l b i o t e c h n o l o g y Liquid c h r o m a t o g r a p h y

GASMIG, pASDELOUPM, PRATVIELG, PITI~M, BERNADOUJ, MEUNIERB 31p ~ ~ t i o n of T ~ lmb.oepl~tes lmmluced o n DNA b y the AtUlfldml N u d e m e 'M~-TMPyP/KHSO S' i n Comptrlson With DNases l ~nd II. Nuc/ew Actds Res 1991, 19 2~35--2839. HAy PE ~ A L C l ~ m y d / a T ~ Detectiott a n d Non-immsl~e Smaplin8 Methods [letter]. Lancet 1991, 338.188. HELMD, IABISO~NSg]H, SCHALLEHNG, NAUMANNI~. Chumtfication and ldemification o f B•ctev~ by Fourk~'-Tnmaform lnb'm'ed Spectroecopy. f Gen Mtcr0bto/1991,137.69"-79 HOANEBR, SI'~LOSAF, PORTERBA, SH1JLMANHM ~ o n of L y m ~ Bone Mmrrow Involvement With MaSm'tic Retamance ) m ~ n o _ B/ood 1991, 78 728-738 Htrt~N M, KEm~& Genomic l m p r i n t i n8 [letter]. Lancet 1991, 3~.1B8 JAMESWH Genomic lmprhaU~qg [letter]. Lancet 1991, 33S-~88. Jor~.s JG, BELUO~E: l ~ . I v . C-13 and N-15 NMR Studies o f Methyhunine Metabolism i n l ~ m d o m o n ~ SpecJ~ M ~ f Biol (l~ra 1991, 266:11705-11713. KRAMERHW, IMIIEYJE Msm Trmmfef Chsrscter/zation o f Jm Airlift Probe for OX~lW~ttn8 m~l l m ~ - ~ Cell s u s l p ~ l o m i n an NMIt Spectmmaeter. B/otec,bn~ Bmeng 1991, 37:205-209. KUESELAC, KROFTT, SMITHICP. Nude~r itesommce Spectroecopy. Aria/Gbem 1991, 63.R237-R246 LUNDBERGP, HARMONE, HO C, VOGELHJ. Nucl~tg Msgnetlc Itesonance Studies o f Cellulsr Metabolbm [ltevk.w]. Aria/B~J~m 199o, 191 193-222. M~CUSOA, ~ EJ, BLANCHHW, CLAm(DS: A Nuclear M q l ~ ' t i c Reaonmu~e Techn/que for

Dg~4~'mnln|n~Hyblr~]k)m Cell COll~(~lttgMtJon i n Hollow lqber B l ~ . B~Ono~o~, 1990, 8:1282-1287 lVI~YESB, HA~EN T, NUTED, AUBERSIEIMP, DARVlLL& YORK W, SELLERSJ. l d e n t ~ c a t i o n o f t h e H-I-NM1 Spectra o f Complex Olil~mochm~les with Neural N ~ . S c m 1991, 251-542-544, MrrcHEL~BW, PAUV~mS. Low.cost ~ l~'oc~in 8 Symem for A n a # ' - ' - ~ I d o l e c u l ~ l ~ A ~ t $ . B~ecbn/qu*s 1990, 9:460-471 OD^ Y, U~UGI S, IKENA~M, Ntm-nMlmAS, KAWASEY, IS~ H, ~ H, OWl'Strr~E. NMR Studies o f • DNA C o n t ~ B-hych'ox~ylw~mosine. Nu~e/c Ac/ds P.*s 1991,19:1407-1412 PATELR a'rA/.. ~ ~Poci~otwa~t ~ o l m and Non-inmtve Smaptin8 methoda [tetter}. Lan,~t 199L 33&188 RYEI-IS,QUESADAMA, PECKK, MATWESRA, GlAiR AN. Hllgh-$etmltivityTwo-Color Detection o f DoubleSttmlded DNA With • ~ F l u ~ e G d Sctt~ter Utdm~ E t l ~ l d l m H ~ mnatl Thltmole Oglnge. Nude~ A~u/s R~s 1991,19 327-333. S ~ TB, BE~gM~a~ML A Method for EhosphollpidMediated D e l i v e ~ o f ~ ' c t f i c Antilmdie~ i n t o Adherent C u i t o r ~ Celia. B ~ / u ~ s 1991, 10:.288 SRIVASTAVAAK, VOLESKYB O Q - I ~ F l U O t ' ~ i c a Mcasuremenm in Assessing Culture Metabolic Actlvttie~..~MMicrobtoIBtotecbnot 1991, 34.'450-457 WmCHENK ~Aa. hmelect~c I F o c u ~ of Amnlotic f l u i d a.fetoproteln to Impt'ove Dialln~i~ o f Neural Tube Defects [letter]. Lancet 1991, 337-674

Liquid chromatography ANDERSONDJ. High-Performance Liquid Chromatowr~hy. AnM Gbem 1991, 63:R213-R219. BLANKG$, VETIEe,mIND. ~ t i f i ~ t i o n o f MoQodotml Antibodies in Complex Mixtures by Pr~tein-G lfl~h-Perftmmance IAquid ~ t y C~'omatoiWaphy. AnalBtochem 1990, 190:317-320 BtmG,~SDE. i a p i d and i n - - l y e DetmitinB o f OaromatoIW~hic ~maplc* after ltPt.C. Bu:~._hn/ques 1990, 9.'624-625 DIAMANDtSEP, C:-WJSTOPOUlZ~"1~ Time-R~olved Immtmoflu~c D e t ~ o n of & B t i ~

~

• Miscellaneous

b

by m~-vefformence Liquid y and C~ted to l'ol~tyrene.

B/oteobn/q~ 1991, 10:646-648 DOU I~ KXmLIS Detetmimttion o f Aromatic and Sulfur-Containing Amino Acids, Peptides, end Proteins U s l ~ lg~h-Perfofmance Uquid C h r o m a t o F u p h y with I~hotOiytic E l e ~ x t ~ h e m l ~ d Dete~ion. Aria/~aera 1990, 62:2599-2606. FED~KO NS, T ~ m ~ JD, ROB~YPG" lflSh-Performance U q u i d C~-omatograplzlc Sepanttion o f H y ~ u r o m m and 4 Proteot#ycat~ Produced by Human Borne Cell Cultoges. Anal Bi~l".~m 1990, 18~.398-.t07. GOLDKORNI, GLEESONPA, TOH BH. Reverse lmmunomm.lty Cht-og~towmphy - Appli(ation to the Purilicatinft o f the 60-kIm to 90.kDa Gastric Pm-iem/Cell Autom~ti~-n ANoctated with Augoilamune ~ t l ~ . Ar~/BgTc,bem 1991, 194:433-.438. HAGEDS, KAO PC. ~ ~ ImnttltttOmf~niW ~ h y and ~ n m l m e ~ c e n ¢ Detection i n t h e Autommtinn o f • l ~ a ~ d Hormone Sandwich I m m ~ . Ana/~aem 1991, 63:586-595. HA~ESD& Jm DJ. BURGESSRI~ Use o f Mono-Q Highie~tinn l o n - ~ c l m m ~ C l u ~ m a t o S m ~ y to Obt~ ~ Pure end Active I~ch~richla-Coli ltNA Polymecase. B/ochem/.m,y1990, ~9:7890-7894. Hma~v.~m J, ITO N, NOGUc-,mK, KAS~K. Slalom

C]m,mmosr,phy:Size~-pendem Sep~tion

of DNA M o l e c u l ~ b y • ~ c Phenomenon. B/o¢.bem/m,'y1990, ~9.9515-9521 JAC~ S, GOISIO~-SHW,/~S, GUtOCHO~G

Oha.tmut~.~F,hic ~

Profiles mull

tJand ~ p e t a t i o n o t Emmtfomet~ • t r a s h Cottcemtr~tto~. JAm G~era S0¢ 1990, 112,6492-649~ LEEYC: ELt#a-Pt~'formance/mion-Exoh~n=ne

om,m~ostWhy for C~bo~ttcate

Anay~,

[Ite~ew]. Aria/B~bem 1990, 189.151-162 L[JY, O-mlSTENSENBM, TRACYJW E l e g t r o d l e m i a d l)eteeminatinn o f IMphenoi-Oxidue/mtivBy Using EBSh-Prgumm Liquid Ohromatogmphy. Am~ B ~ 1990, 190.-354-659. NAKAHARAT, ~ A j, YAMAGUCHIM. NAKAMURAM Detet'minmion of Alplm-Kem &ctds I n d u d i n 8

~ c ~mUlin ~mmm E t ~ m by m ~ t'et'formmtce Liquid Chromatotp'aphy with Ch~lnmin~lcelm,3e D~-tectlon. A n a l B ~ e m 1990, 190:309-313. OV,~'A Y, KONOO3", KOUOOT: Sepm'mimz o f DNA Frqments by Hlsh-llesolution lon-E~h-.'.=-e C ~ h y o n • Nonporous Q~ Column. Arta/B/oG~ra 1990, 189'126-130. RANnO~H TW: Supefcrltical Fluid E x t r a c t i o m i n Bl~losy. Trends B/otec/mo/1990, 8 78--81 R[GGINA, REGN~RFE, SPOgrSMANJl~ Qu~atlfieation o f Antibodies to l l m m m Growth Hormone by HlshPeffogma~ce P r m e ~ - G Amni W Chromatowmphy With F l u ~ e Detectio~. Aria/(~aem 1991, 63 468-474, SIEGELPD, 12WISDM, OLENCHOCKS~. l ~ - P e g f o g M ~ t n c e Liquid ChfotmttoSt~phic Method for the ]~vnhmtion o f Po~iBle i n t e f f e t ~ c e s i n Basophli i~hrmmine l e l e • s e M4msurements. Area/B/oc.bem 1990. 1S~t:416-421. SMITNPM, PAVELS, KAMMEYERA, WESTERHOF W. ~ o n o f Cateclhol OM e t h # m m s f e r a ~ Activity i n l e l m t o n to M-t~.~a. l~-tabolism U s I ~ l~gh-Performance Liquid OUurommtoIp'mpbyWith Fluorimetrlc ~-tectton. Aria/B/oa~m 1990, 190286-291 VOLLMF.RDW, JmKS DC, G ~ R. Isoccadc RevtrseLkluld Chromatowmphy Assay for Amino Acid Metabolic Disorders Using Bluates o f Dried Blood Spot*. Aria/B/0chem 1990, 189.115-121 WARRENW, DONIGERJ. ll]PLC INtrl~attio~ o f Polymet'm~ Chain aeactfon Products for Direct Sequencin 8. B~ecbng/ues 1991, 10:216

Miscellaneous AN GH, BEUCHJ, AUERBACHR, JOHNSONEA: l~ol~tion and C h a t t c t e a z a t i o n of Carotenoid Hylmrproducin 8

Mutants o f Yeast by Flow Cytometry •rid Cell Sorting. B/otec/m~b~ 1991, 9.70-73, BANOMC, COIEN S, VISSCI~RKB, ALLCOCKHR, LANGERR. A Novel Synthetic Method for Hylzfl.donm CeU Encapeulation. Bk~tecbno~ 1991, 946&-471 BENDERJG, UNV~RZAGTKI, WALKERDE, LEEW, VANEPPS DE, SMITHDH, STEWAKrCC, TO LB ideatl~QttloB and C o m ~ o f CD34-pc~itlve C e l b a n d Their Subpopuhttinns from Normal Peripheral Blood and Bone ~ Usln8 Multicofog Mow Cytometry. B/ood 1991, "?Y'2591-2596 DANIEL~ONB Catlot'~ettlc B|o~.lu~es. f B/otedan~ 1990, 15 187-200. FLYGAREI~ ~ N PO, DANIEiSSONB Control o f am AJ~tlty pmtlicatton Procedure Using s T h ~ u t l B|om~utor. BggecAm~B/oeng 1990, 36 723-726 ]£)CKETTSJ. JACOBSONl~ ORANDM, KAUFM DG, CORCORAN M, SIMONSENMG, TAYLDRH, HERMANB: Automuttgd Imqge-lSa~.d Cytometry with muoreKenceStained Slmcimens. B~.ec./m/qu~ 1991, 10:514-519 MANSFELDJ. FORSTERM, SCHELLENBERGERA, DAU'I2ENBERGH: lmmoBllbmflott o f ~ by Fatc•p~dmJon m Pol3~iectrolyte Complexes. Enzyme Mt~rob Tedmol 1991, 13.240-244 MONSHIFOURIM, NEUI~LDRJ Activity and Dlm0rlbutinn o f u r t ~ e FoUowin8 M i ~ o n Within Polya~ide M e m l m m ~ , Enzyme Mgmb Tedmo/ 1991, 13:309-313 NAKAYAMAH, FIAyASH11", S&L&TAKF, ~ AL ]~ow ~ m e U - y to Identify Ceu Typ~ to ~bich

~ u ~ m a llind - Effect of Lmctlc Deb~h~qume Virus on Emtyme B~nm~- J 8 J o / ~ n 1990, 265:14355-14357 NIR P~ YISE~UY, LO~D R, SAHARE: Flow CFtometry S o f t i n j o f Vbdge ~ and Y e a t s Accotdin8 tO ~ ACtiVity. A I ~ Environ Ma:rob~ 1990, 56:3861--3866. PERSSONM, BULOWL, ~ K: Pm'tfIOtttottt Site-fq~'~tfic immobli~i=mton o f Genetically

F,n~teet~ Glucene ~

on

Tmoprop#-Sep~. W_.BSLeu 1990, 27o.41-44. pmME KL WHrr~s~0EsG ~ Self-Amembled OrBanic

Mono~ters - Model Systems for smdyin8 M s o r p t i o n o f Proteltm at Surfsces. $ckon~e 1991, 292.1164-1167. RADpARVARS, FUNGG, NOD 'IT. Simple, Quick mad Efficient S i t e - ~ Antibody lmmob4liamion i n a Owtrid~e. B ~ / u e s 1990, 9632. SALEEMUDDINM, HUSA~Q C o n c t m a v ~ - A - • Useful U s a n d for G l y c ~ lmmobUlaminn - • Review. Enzyme M/~r0b Tedamo/1991, 13:2~)0--295 SIENAS, BREGNIM, BEANDOB, BELl/N, RAVAGNAN1F, GANDOL~I~ STERNAC, ~qSlX)EP PM, BONADONNA G, G~NN~AM. Flow Cytometry for Clinical Estimation o f Citculatin8 Hematopoietic Prolte~tors for AutOIosous Tnumphmmtion tn Cancer Patienta. B/o0d 1991,"~/:400-409. STEFUCAV, GE~INERP, KURllLOVAl~ DANEL~ONB, BALESV A p p U ~ o n o f t h e Enzyme T h ~ t o the Direct Estimation o f Intrinsic Kinetics Usin8 the ~ccbm.~ee-lmmobilized lm,ertme ~mtem. Enzyme M/crab Tedm0/1990, 12:830-835 TERSTAPPENLWMM,JOHI~EN S, SEGERS-NOLTENIMJ, LOK~N MR: Ide~ti~¢•tion a n d Chsttmtetiz~tion o f Plasma Ceils hmNormal H - r a i n Bone Matt'row by Ellsh-re.olution Flow Cytometry. B/ood1990, 76:1739-1747. VANDER SCHoor CE, HUI~NGATWJ, VAN'TVEERKorrHoF ET, WUMANSIL P~SrER J, VON HEM B o ~ AEG~LDeficiency o f Glyco~lphmtphatidylino~itOl-~ Membrane Giyenproteins o f Leukocytes in P u o x y s m a l Nocturnal HemoMfobinuri~ Description o f • New Dlasno~tc Cytofluorometrlc Assay. B/ood 1990, 76.1853-1859 VENERAV, EVTUSHENKOOA, BAYKOVA& Use o f BioUnyl~ted I n o r ~ t n i c Py~opho~pimtme for I~mmction o f l l l o t i n Bound tO Solid Support. Arm/ Bto66em 1990, 191.~5-69 WAH~RENM, ARNEBRANTT- Protein Adma~ption tO Solid Surf~ce~, Trends B~oteoM*0/199], 9,201--207 ZARAJJ, WOODRD, BOON P, KIMCH, POMATON, BREDEHOgSTl~ VOGELCW A ~'bohydg~te-][]~'~'cted H~t£Yob~-~ttctlol~d Cl'o~lJnkln=a Reagent for the Synthesis o f Immmtmoconjus•tes. Anal Btochem 1991, 194.156--162