Acta Med Scand 205: 191-194, 1979

Analgesic Treatment with Levomepromazine in Acute Myocardial Infarction A Randomized Clinical Trial

Otto Davidsen, Ole Lindeneg and Mark Walsh From Medicul Department P , Bispebjerg Hospital, Copenhagen, Denmurk

ABSTRACT. The efficacy of a non-narcotic analgesic is evaluated in a double-blind randomized series of patients with acute myocardial infarction (AMI). Levomepromazine or pethidine were given in 328 consecutive cases to 316 patients within 24 hours after the onset of symptoms. Levomepromazine, 12.5 mg, appeared as effective as pethidine, 50 mg, in the alleviation of pain, though the initial dose had to be higher. Nausea and vomiting were half as frequent in the levomepromazine group as in the pethidine group (p0.05 (X2-test)

mias and bradyarrhythmias showed no difference (Table 11). Systolic B P (mean k S.D.) on admission was for the levomepromazine group 1501-38 mmHg and for the pethidine group 151+32 mmHg. One hour later it was 131+29 and 137+30 mmHg, respectively. This fall in BP was not significant (p>0.05, Student's r-test). The incidence of hypotension did not differ between the groups during the first hour, when medication was at its peak (Fig. 3). The incidence of dizziness, mental disturbance and urinary retention was equal and totalled less than 8% in both groups. The incidence of embolisms was 1 % in both groups. Dryness of the mouth, which is particularly prominent in levomepromazine therapy, appeared in this group in 59% of cases, but also in 27% of the patients treated with pethidine (p

Analgesic treatment with levomepromazine in acute myocardial infarction. A randomized clinical trial.

Acta Med Scand 205: 191-194, 1979 Analgesic Treatment with Levomepromazine in Acute Myocardial Infarction A Randomized Clinical Trial Otto Davidsen,...
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